DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76a and Grin3b

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	85/401 - (21%)
Similarity:	146/401 - (36%)	Gaps:	122/401 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 GLVGMILDRRNDYGVGGMYLWYEAYEYMDMTH-FLGRS-GV---TCLVPAPNRLISWTLLLRPFQ 358
            ||||.:|..|....|....:.....:.:|.|. |...| |:   |....:|.....|     |..
  Rat   515 GLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMW-----PLH 574

  Fly   359 FVLWMCVMLCLLLESLAL---------GITRRWEHSSVAAGNSWISSLR------FGCISTLKLF 408
            :.:|:.|...|.|.:|.|         |:|.|..:.....  |:.|:|.      ||...:.|..
  Rat   575 WSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVF--SYSSALNLCYAILFGRTVSSKTP 637

  Fly   409 VNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILT-LPTLEEAADSRQRLFDHKL---- 468
            ...:..::.:.:|:..:||.|         .|:..|||::. ..|.||.:.    :.|.||
  Rat   638 KCPTGRFLMNLWAIFCLLVLS---------SYTANLAAVMVGDKTFEELSG----IHDPKLHHPS 689

  Fly   469 -------IWTGTSQAWI-TTIDERSADPVLLGLMEHYRVYDANLISAFSHTEQMGFVVERLQFGH 525
                   :|..:::|:| .:..|..|         |.|.:.|       .|...|
  Rat   690 QGFRFGTVWESSAEAYIKASFPEMHA---------HMRRHSA-------PTTPHG---------- 728

  Fly   526 LGNTELIENDALKRLKLMVDDIYFAFTVAF---------------------VPRLWPHLNAYNDF 569
               ..::.:|..|....::|.....:.|:.                     :|:..|..:..::|
  Rat   729 ---VAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEF 790

  Fly   570 ILAWHSSGF-----DKFWEWKIAAEYMNAHRQNRIVASEKTNLDIGPVKLGIDNFIGLILLWCFG 629
            |..:.||||     ||:::.....:        |:.|..:|      :::|:.:|.||.:|.|.|
  Rat   791 ISRYKSSGFIDLLHDKWYKMVPCGK--------RVFAVTET------LQMGVYHFSGLFVLLCLG 841

  Fly   630 MICSLLTFLGE 640
            :..:|||.|||
  Rat   842 LGSALLTSLGE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	69/341 (20%)
		Lig_chan	576..842	CDD:278489	62/323 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350128
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930