Protein Alignment Ir76a and Grin2a

DIOPT Version :9

• Sequence 1: NP_001097647.3
• Gene: Ir76a / 40157
• FlyBaseID: FBgn0260874
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 700
• Identity: 124/700 - (17%)
• Similarity: 233/700 - (33%)
• Gaps: 230/700 - (32%)

  Fly    46 PMPLIIMDWHRWANRSDQDVYDYKIKEDEFEGKGIPYNDWTLRLTVAIERSHCETFIAF------ 104
            |..||.:.:..|         ||.::....:|.||        ||.|.. |..|.|...
Mouse   273 PSGLISVSYDDW---------DYSLEARVRDGLGI--------LTTAAS-SMLEKFSYIPEAKAS 319

  Fly   105 ---QEQIPEFARYFYHASIYSI-WRSLRNRFMFVYTKEFEDKKDSYLSGYIFQDQPNILVITSQY 165
               |.:.||...:..|..:.:: |                |.||...:...:|..|.::||.
Mouse   320 CYGQTEKPETPLHTLHQFMVNVTW----------------DGKDLSFTEEGYQVHPRLVVIV--- 365

  Fly   166 LNSSTFEIKTNRFVGPRNFNKNPEPVEFYILQRFDAKGTKATWETQS-----AMSSKMRNLKGRE 225
                              .||:.|         ::..|   .||.|:     |:..:.::....|
Mouse   366 ------------------LNKDRE---------WEKVG---KWENQTLSLRHAVWPRYKSFSDCE 400

  Fly   226 -----VVIGIFDYKPFMLLDYEKPPLYYD---------RFMNTTDVTIDGTDIQLMLIFCELYNC 276
                 :.|...:..||:::: :..||...         :|:...:.|.:|.:::..   |:.:..
Mouse   401 PDDNHLSIVTLEEAPFVIVE-DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKC---CKGFCI 461

  Fly   277 TIQVDTSEPYDWG-DIYLNASG----------YGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTH 330
            .|....|....:. |:||..:|          .|::|.::.:|....||.:.:..|..|.:|.:.
Mouse   462 DILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSV 526

  Fly   331 FLGRSGVTCLVPAPNRLISWTLLLRPFQFVLWMCVMLCLLLESL----------ALGITRRWEHS 385
            ....:|::.:|...|..:|.:..|.||...:|:.:.:.||:.|.          .:|..|.....
Mouse   527 PFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKG 591

  Fly   386 SVAAGNS-------WISSLRFGCISTLKLFVNQSTNYVTSSYALRTVLVASY-MIDIILTTVYSG 442
            ....|.|       |   |.:|      |..|.|............::|:.: ...:|....|:.
Mouse   592 KAPHGPSFTIGKAIW---LLWG------LVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTA 647

  Fly   443 GLAAILTLPTLEEAADSRQRLFDHKL--------------IWTGTSQ-----------AWITTID 482
            .|||.:   ..||..|....|.|.|.              :..|:::           .::|..:
Mouse   648 NLAAFM---IQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFN 709

  Fly   483 ERSADPVLL----GLMEHYRVYDANLISAFSHTEQ--------MGFVVERLQFGHLGNTELIEND 535
            :|..:..|:    |.::.: :|||.:::..:..::        .|::.....:|    ..|.:..
Mouse   710 QRGVEDALVSLKTGKLDAF-IYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYG----IALQKGS 769

  Fly   536 ALKRLKLMVDDIYFAFT----VAFVPRLWPHLNAYNDFILAWHSSGFDKFWEWKIAAEYMNAHRQ 596
            ..||   .:|.....|.    :..:..||.....:|:                           :
Mouse   770 PWKR---QIDLALLQFVGDGEMEELETLWLTGICHNE---------------------------K 804

  Fly   597 NRIVASEKTNLDIGPVKLGIDNFIGLILLWCFGMICSLLTFLGE---LWR 643
            |.:::|:          |.|||..|:..:....|..||:||:.|   .|:
Mouse   805 NEVMSSQ----------LDIDNMAGVFYMLAAAMALSLITFIWEHLFYWK 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	35/185 (19%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	73/422 (17%)
		HisJ	<458..>541	CDD:223904	16/82 (20%)
		Lig_chan	556..828	CDD:278489	51/328 (16%)
		NMDAR2_C	839..1464	CDD:287527	1/5 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930