DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76a and Grid1

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	550	Identity:	98/550 - (17%)
Similarity:	185/550 - (33%)	Gaps:	168/550 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 RNFNKNPEPVEFYIL-----QRFDAKGTK-ATWETQSAMSSKMR------NLKGREVVIGIFDYK 234
            |..:.||. |:|.||     :.|.....| |||:::..::..::      .|:|..:.:.....:
Mouse   384 REDSSNPY-VQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEE 447

  Fly   235 PFMLLDYE---KPPLYYDRFMNTTDVTIDGTDIQLMLIFCELYNCTIQVDTSEPYDWGDIYLNAS 296
            ||:::...   :|..|            .|..|.::....:......::..:....:|....|.|
Mouse   448 PFVMVAENILGQPKRY------------KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTS 500

  Fly   297 GYGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNRLISWTLLLRPFQFVL 361
            ..|::|.::.:|.|..:..:.:..|....:|.:.......|..|:..|...||...|..||.|.:
Mouse   501 WNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAV 565

  Fly   362 WMCVMLCLLLESLALGITRRWE------------------HSSVAAGNSWISSLRFGCISTLKLF 408
            |.|:...:.:..:.:.:..|.:                  ||::     ||.   :|.      |
Mouse   566 WACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRPSASATLHSAI-----WIV---YGA------F 616

  Fly   409 VNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADSRQRLFDHKLIWTGT 473
            |.|......:|.|:|.|:.:.::..:|:.:.|:..|||.||:..::....:.|.|.....:..||
Mouse   617 VQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGT 681

  Fly   474 ------------------------SQAWITTIDERSADPVLLGLMEHYR---------VYDANLI 505
                                    ::.|.|......||..:....|..|         ::|..::
Mouse   682 VRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKGNYAFLWDVAVV 746

  Fly   506 SAFSHTE-------------QMGFVVERLQFG----HLGNTELIE------NDALKRLKLMVDDI 547
            ...:.|:             ..|:.: .||.|    .|.:..::|      .|.||:
Mouse   747 EYAALTDDDCSVTVIGNSISSKGYGI-ALQHGSPYRDLFSQRILELQDTGDLDVLKQ-------- 802

  Fly   548 YFAFTVAFVPRLWPHLNAYNDFILAWHSSGFDKFWEWKIAAEYMNAHRQNRIVASEKTNLDIGPV 612
                      :.|||....:   |..|||                            |..:...:
Mouse   803 ----------KWWPHTGRCD---LTSHSS----------------------------TQTEGKSL 826

  Fly   613 KLGIDNFIGLILLWCFGMICSLLTFLGELW 642
            ||  .:|.|:..:...|::.:.|....|||
Mouse   827 KL--HSFAGVFCILAIGLLLACLVAALELW 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		13/52 (25%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	12/39 (31%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	68/414 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846304
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840