DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76a and Gria2

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	497	Identity:	97/497 - (19%)
Similarity:	178/497 - (35%)	Gaps:	117/497 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 ANRSDQDVYDY-------------KIKEDEFEGKGIPYNDWTLRLTVAIERSHCETFIAFQEQIP 109
            ||.|...:.||             .::|.|:.|.......:|..||....:...|.|...::|..
Mouse   255 ANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRI 319

  Fly   110 EFARYFYHASIYS-----------IWRSLRNRFMFVYTKEFEDKKDSYLSGYIFQDQPNILVITS 163
            |.:|........:           |.|:|:.       .:.|.     |||.|..||      ..
Mouse   320 EISRRGNAGDCLANPAVPWGQGVEIERALKQ-------VQVEG-----LSGNIKFDQ------NG 366

  Fly   164 QYLN--SSTFEIKTNRFVGPRNFNKNPEPVEFYILQRFDAKGTKATWETQSAMSSKMRNLKGREV 226
            :.:|  .:..|:|||   |||......|..:..:..            |:....:....|:.:.|
Mouse   367 KRINYTINIMELKTN---GPRKIGYWSEVDKMVVTL------------TELPSGNDTSGLENKTV 416

  Fly   227 VIGIFDYKPFMLLDYEKPPL----YYDRFMNTTDVTID-----GTDIQLMLIFCELYNCTIQVDT 282
            |:......|::::......|    .|:.:  ..|:..:     |...:|.::....|... ..||
Mouse   417 VVTTILESPYVMMKKNHEMLEGNERYEGY--CVDLAAEIAKHCGFKYKLTIVGDGKYGAR-DADT 478

  Fly   283 SEPYDWGDIYLNASGYGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNR- 346
            .   .|.         |:||.::..:.|..:..:.:.....|.:|.:......|::.::..|.:
Mouse   479 K---IWN---------GMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 531

  Fly   347 ---LISWTLLLRPFQFVLWMCVMLCLLLESLALGITRR-----WEHSSVAAG---NSWISSLRFG 400
               :.|:   |.|..:.:|||::...:..|:.|.:..|     |.......|   .|..|:..||
Mouse   532 KPGVFSF---LDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFG 593

  Fly   401 CIS----TLKLFVNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILT----LPTLEEAA 457
            ..:    :|..|:.|..:....|.:.|.|....:...:|:.:.|:..|||.||    :..:|.|.
Mouse   594 IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAE 658

  Fly   458 D-SRQRLFDHKLIWTGTSQAW-----ITTIDE-----RSADP 488
            | |:|....:..:.:|:::.:     |...|:     |||:|
Mouse   659 DLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEP 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	35/163 (21%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	60/306 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840