Protein Alignment Ir76a and GRIN3B

DIOPT Version :9

• Sequence 1: NP_001097647.3
• Gene: Ir76a / 40157
• FlyBaseID: FBgn0260874
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_619635.1
• Gene: GRIN3B / 116444
• HGNCID: 16768
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 119/598 - (19%)
• Similarity: 215/598 - (35%)
• Gaps: 204/598 - (34%)

  Fly   163 SQYLNSSTFEIKTNRFVGP------------RNFNKNPEPVEFYILQRFDAKGTKATWETQSAMS 215
            :::|.:::|:.:|    ||            |:|       :.:.|:| |.:|..| |.|..:..
Human   339 ARFLANTSFQGRT----GPVWVTGSSQVHMSRHF-------KVWSLRR-DPRGAPA-WATVGSWR 390

  Fly   216 SKMRNL------------KGREV-----VIGIFDYKPFMLL-----DYEKP--PLYYDRFMNTTD 256
            ....:|            :|.:|     |:.:.:: ||:..     |.:.|  .|..|...|.:
Human   391 DGQLDLEPGGASARPPPPQGAQVWPKLRVVTLLEH-PFVFARDPDEDGQCPAGQLCLDPGTNDS- 453

  Fly   257 VTIDGTDIQLMLIFCELYN--------------CTIQVDTSE------PYDWGDIYLNASG---- 297
            .|:|.       :|..|.|              |   :|..|      |:|: ::||...|
Human   454 ATLDA-------LFAALANGSAPRALRKCCYGYC---IDLLERLAEDTPFDF-ELYLVGDGKYGA 507

  Fly   298 ------YGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNRLISWTLLLRP 356
                  .||||.:|..|....|....:.....:.:|.|.....:.:..:|.|.:........:.|
Human   508 LRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWP 572

  Fly   357 FQFVLWMCVMLCLLLESLAL---------GITRRWEHSSVAAGNSWISSLRFGCISTL-KLFVNQ 411
            ..:..|:.|...|.|.:|.|         |:|.|..:.|...  |:.|:|.. |.:.| :..|:.
Human   573 LHWSTWLGVFAALHLTALFLTVYEWRSPYGLTPRGRNRSTVF--SYSSALNL-CYAILFRRTVSS 634

  Fly   412 ST------NYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILT-LPTLEEAADSRQRLFDHKL- 468
            .|      ..:.:.:|:..:||.|         .|:..|||::. ..|.||.:.    :.|.||
Human   635 KTPKCPTGRLLMNLWAIFCLLVLS---------SYTANLAAVMVGDKTFEELSG----IHDPKLH 686

  Fly   469 ----------IWTGTSQAWITTIDERSADPVLLGLMEHYRVYDANLISAFSHTEQMGFVVERLQF 523
                      :|..:::|:|     :.:.|   .:..|.|.:.|       .|...|
Human   687 HPAQGFRFGTVWESSAEAYI-----KKSFP---DMHAHMRRHSA-------PTTPRG-------- 728

  Fly   524 GHLGNTELIENDALKRLKLMVDDIYFAFTVAF---------------------VPRLWPHLNAYN 567
                 ..::.:|..|....::|.....:.|:.                     :|:..|..:..:
Human   729 -----VAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLS 788

  Fly   568 DFILAWHSSGF-----DKFWEWKIAAEYMNAHRQNRIVASEKTNLDIGPVKLGIDNFIGLILLWC 627
            :||..:.||||     ||:::.....:        |:.|..:|      :::.|.:|.||.:|.|
Human   789 EFISRYKSSGFIDLLHDKWYKMVPCGK--------RVFAVTET------LQMSIYHFAGLFVLLC 839

  Fly   628 FGMICSLLTFLGE 640
            .|:..:||:.|||
Human   840 LGLGSALLSSLGE 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	19..405	CDD:107372	15/78 (19%)
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	87/449 (19%)
		Lig_chan	576..842	CDD:278489	63/323 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156190
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840