DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76a and GRIN3A

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	637	Identity:	120/637 - (18%)
Similarity:	209/637 - (32%)	Gaps:	242/637 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 QPNILVITS---------------QYLN-----------SSTFEIKTNRFVGPRNFNKNPEPVEF 193
            ||.:.:|.|               |||:           |.:..:|.:..|...|        .|
Human   407 QPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSEN--------NF 463

  Fly   194 YI--LQRFDAKGTKATWETQSAMSSKMRNLKGREVVI--GIFD-----YKPFMLLDYEKPPLYYD 249
            :|  ||. |..| |..|       :::.:.:|.::|:  ||:.     :|    ..::.|...:.
Human   464 FIWNLQH-DPMG-KPMW-------TRLGSWQGGKIVMDYGIWPEQAQRHK----THFQHPSKLHL 515

  Fly   250 R--------FMNTTDVTIDG--TDIQLML------------IFCELY--NCTIQ----------- 279
            |        |:.|.:|..:|  ...||.|            :|..|:  |.|:.
Human   516 RVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYC 580

  Fly   280 VDTSEP------YDWGDIYL----------NASGYGLVGMILDRRNDYGVGGMYLWYEAYEYMDM 328
            :|..|.      :|: |:|:          |....||||.:|.......|....:.....:.:|.
Human   581 IDLLEKIAEDMNFDF-DLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDF 644

  Fly   329 THFLGRSGVTCLV-----PAPNRLISWTLLLRPFQFVLWMCVMLCLLLESLAL---------GIT 379
            |.....:.:..||     .||.....|     |..:.:|:.:.:.|.:.::.|         |:|
Human   645 TSPFFSTSLGILVRTRDTAAPIGAFMW-----PLHWTMWLGIFVALHITAVFLTLYEWKSPFGLT 704

  Fly   380 RRWEHSSVAAGNSWISSLRFGCISTLKLFVNQSTNYVTSSYAL---RTVLV-------ASYMIDI 434
            .:..:.|                   |:|...|.  :...|||   |||.:       ..:::::
Human   705 PKGRNRS-------------------KVFSFSSA--LNICYALLFGRTVAIKPPKCWTGRFLMNL 748

  Fly   435 ------ILTTVYSGGLAAILTLPTLEEAADSRQRLFDHKLIWTGTSQAW-ITTIDERSAD----- 487
                  ...:.|:..|||::   ..|:..:....:.|.||  ...||.: ..|:.|.||:
Human   749 WAIFCMFCLSTYTANLAAVM---VGEKIYEELSGIHDPKL--HHPSQGFRFGTVRESSAEDYVRQ 808

  Fly   488 --PVLLGLMEHYRVYDANLISAFSHTEQMGFVVERLQFGHLGNTELIENDALKRLKLMVDDIYFA 550
              |.:...|..|.|....                       ...|.::||..|....::|.....
Human   809 SFPEMHEYMRRYNVPATP-----------------------DGVEYLKNDPEKLDAFIMDKALLD 850

  Fly   551 FTVAF---------------------VPRLWPHLNAYNDFILAWHSSGF-----DKFWEWKIAAE 589
            :.|:.                     :|...|.....::.|..:.|.||     ||::
Human   851 YEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWY------- 908

  Fly   590 YMNAHRQNRIVASEKTNLDI-GPVKLGIDNFIGLILLWCFGMICSLLTFLGE 640
                    |:|...|.:..: ..:::||.:|.||.:|.|.|...|:||.:||
Human   909 --------RVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	23/106 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	13/69 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	79/450 (18%)
		Lig_chan	676..942	CDD:278489	57/329 (17%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		2/2 (100%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840