Protein Alignment Ir76a and grin2ca

DIOPT Version :10

• Sequence 1: NP_001097647.3
• Gene: Ir76a / 40157
• FlyBaseID: FBgn0260874
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 649
• Identity: 130/649 - (20%)
• Similarity: 227/649 - (34%)
• Gaps: 178/649 - (27%)

  Fly    85 WTLRLT------VAIERSHCETFIAFQEQIPEFARYFYHASIYSIWRSLRNRFMFVY-------T 136
            |.:.|.      |||.....|:|...:..||:     .|....|..|...|..::.:       .
Zfish   292 WKMSLRNRVRDGVAIVVKGVESFRKQRGFIPD-----GHMDCLSPIRPASNGTLYRHMLNVSWEN 351

  Fly   137 KEFEDKKDSYLSGYIFQDQPNILVIT----SQYLNSSTFE--IKTNRF-VGPRNFNKNPEPVEFY 194
            .:|....|.||.      .|::::||    .|:.....:|  |...|: |.|| :....|||.
Zfish   352 TDFSFNSDGYLV------NPSMIIITLDRGRQWDKVGNYESGILQMRYPVWPR-YGTFLEPVS-- 407

  Fly   195 ILQRFDAKGTKATWETQSAMSSKMRNLKGREVVIGIFDYKPFMLLDYEKP--------PLYYDRF 251
                                       ..|.:.:...:.:||::::...|        .:...|.
Zfish   408 ---------------------------DNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPCRRQ 445

  Fly   252 MNTTDVTIDGTDIQLMLIFCELYNCTIQVDTSEPYDWG-DIYLNASG----------YGLVGMIL 305
            .|.|:..:..|:....|. |:.:...|....|....:. |:||..:|          .|::|.:.
Zfish   446 SNKTETIVGHTEPYTKLC-CKGFCIDILKKLSRNIKFSYDLYLVTNGKHGKLVRGIWNGMIGEVF 509

  Fly   306 DRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNRLISWTLLLRPFQFVLW-MCVMLCL 369
            .:|.|..:|.:.:..|..|.:|.:.....:|::.:|...|..:|.:..|.|:...:| |..::||
Zfish   510 YKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCL 574

  Fly   370 LLESLALGITRRWEH-SSVAAGNSWISS---------------LRFGCISTLKLFVNQSTNYVTS 418
            .:.::.:.:   :|: |.|....|.:|:               |.:|.:....:.:.....  |:
Zfish   575 TVVAVTVFV---FEYCSPVGYNRSLVSAKDPGGPTFTIGKSVWLLWGIVFNNSVPIENPKG--TT 634

  Fly   419 SYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADSRQRLFDHKLIWTGTSQAWITTIDE 483
            |..:  |||.::...|.|.: |:..|||.:   ..|:..|:...|.|.|.              :
Zfish   635 SKIM--VLVWAFFAVIFLAS-YTANLAAFM---IQEQYIDTVSGLSDKKF--------------Q 679

  Fly   484 RSAD---PVLLGLMEHYRVYDANLISAFSHTEQMGFVVERLQFGHLGNTELIENDALKRLKLMVD 545
            :..|   |...|.:.:... :.|:.|  ::.|....:|:..|.|       :| |||..||....
Zfish   680 KPQDQYPPFRFGTVPNGST-ERNIRS--NYPEMHSHMVKYNQKG-------VE-DALNSLKTGKL 733

  Fly   546 D--IYFAFTVAFVPRLWPHLNAYND-------------FILAWHSSGFDKFWEWK----IAAEYM 591
            |  ||.|..:.::        |..|             |....:.....|...||    :|....
Zfish   734 DAFIYDAAVLNYM--------AGKDEGCKLVTIGSGKVFATTGYGIALQKESRWKRPIDLALLQF 790

  Fly   592 NAHRQNR---------IVASEKTNLDIGPVKLGIDNFIGLILLWCFGMICSLLTFLGE---LWR 643
            .|....:         |..:||.  ::...||.|||..|:..:....|..|||.|..|   .|:
Zfish   791 LADGDTQKLQTVWLTGICRNEKK--EVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWK 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..393	CDD:380601	23/111 (21%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	85/445 (19%)
		NMDAR2_C	847..>938	CDD:463148	1/6 (17%)