DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG14102 and FBXL14

DIOPT Version :9

Sequence 1:NP_649147.2 Gene:CG14102 / 40156 FlyBaseID:FBgn0036906 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_689654.1 Gene:FBXL14 / 144699 HGNCID:28624 Length:418 Species:Homo sapiens


Alignment Length:411 Identity:81/411 - (19%)
Similarity:150/411 - (36%) Gaps:110/411 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LGCPFSFLVGRPQSMSGGPGFLDLNYD-------------CYHQIFSYINVLEDQLNLGRAHP-L 56
            :.|.|      |:.::...|:||:...             .||:  |....:|.:|:|.||:| |
Human     5 ISCLF------PELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHK--SVWRGVEAKLHLRRANPSL 61

  Fly    57 FQVVLTDILRTRHKKINVRLLKTIPDWEFLLQ----LCGSEVSRCEVPHGSWDEPFTYPFLGLLG 117
            |..:....:|      .|::|.......:::|    :....:|.|   :...|....:.|:..:|
Human    62 FPSLQARGIR------RVQILSLRRSLSYVIQGMANIESLNLSGC---YNLTDNGLGHAFVQEIG 117

  Fly   118 RHCPKLRQAVIIFMHAVTESPPKSGDRGHIMQLL-----LELPSLTNLT----------LIDARS 167
                .||...:.....:|:|     ..|.|.|.|     |||...:|:|          |...:|
Human   118 ----SLRALNLSLCKQITDS-----SLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKS 173

  Fly   168 AQLDQLRHFSK-------------------LEALDLDGIDPNLSNASFQQMFESMASLKRLLLNF 213
            ..|...||.|.                   ||.|.|.... .|::.|.:.:...:..|:.|.|:|
Human   174 LNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQ-KLTDLSLKHISRGLTGLRLLNLSF 237

  Fly   214 ------GPDRRRSHQVPLLADKFPNLDH-------------LTLENFDMSF-PELGE------FK 252
                  ......||...|.:....:.|:             |.|...|:|| .::|:      .:
Human   238 CGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQ 302

  Fly   253 GLRSLRLISRWTAEVDNDFYRSVAKRVSNLQKL---QLISVRVRGDQV--HHILAIRQLNALDCD 312
            ||..|:.:|..:..:.:|....:.:::..|:.|   |.:.:..:|.::  .|:..:..::...|.
Human   303 GLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCT 367

  Fly   313 NWPAQSVSQLGQLKDLECLAL 333
            ....:.:.::.||..|:.|.|
Human   368 RITKRGLERITQLPCLKVLNL 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14102NP_649147.2 None
FBXL14NP_689654.1 Required for down-regulation of SNAI1 2..48 9/50 (18%)
F-box-like 5..46 CDD:403981 9/48 (19%)
AMN1 90..296 CDD:187754 44/218 (20%)
leucine-rich repeat 92..118 CDD:275381 5/32 (16%)
leucine-rich repeat 119..142 CDD:275381 7/27 (26%)
LRR 1 144..163 5/18 (28%)
leucine-rich repeat 145..170 CDD:275381 6/24 (25%)
LRR 2 170..191 5/20 (25%)
leucine-rich repeat 171..203 CDD:275381 5/31 (16%)
LRR 3 203..225 6/22 (27%)
leucine-rich repeat 204..229 CDD:275381 6/25 (24%)
AMN1 228..401 CDD:187754 30/161 (19%)
LRR 4 229..250 4/20 (20%)
leucine-rich repeat 230..254 CDD:275381 6/23 (26%)
LRR 5 254..275 2/20 (10%)
leucine-rich repeat 255..280 CDD:275381 2/24 (8%)
leucine-rich repeat 281..306 CDD:275381 7/24 (29%)
leucine-rich repeat 307..331 CDD:275381 3/23 (13%)
leucine-rich repeat 332..357 CDD:275381 5/24 (21%)
leucine-rich repeat 358..382 CDD:275381 3/23 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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