Protein Alignment SREBP and HMS1

DIOPT Version :9

• Sequence 1: NP_001262064.1
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_014675.1
• Gene: HMS1 / 854197
• SGDID: S000005558
• Length: 434
• Species: Saccharomyces cerevisiae
• Alignment Length: 394
• Identity: 84/394 - (21%)
• Similarity: 140/394 - (35%)
• Gaps: 129/394 - (32%)

  Fly   118 SYNCPQQQPTGLLKAAQP-------TATIHHMDAQRMPPNTAVYPPSLGSSFVYQSM-SPPTSPV 174
            :|..|.|.|..|.....|       :||..:.|:..  |||:.:.|.:.|::...:: |.||:..
Yeast    81 AYYAPFQHPIHLQPPVPPVYKNNTYSATDQYSDSSF--PNTSGHTPVIDSNYYNDALASIPTTTT 143

  Fly   175 ESA--------------------------NQNV-NVMQPVAATPAPASAPLPQQSYPQPFITYNS 212
            .|.                          |:|: ||.|....:...:|              ..|
Yeast   144 GSTTMTTDNGNTIDSEEYIDNMEVFSSEENENIDNVKQTDLKSEKDSS--------------LLS 194

  Fly   213 KAGMTSDEAMYFLLQPTVASPTPSPPVAPPPTSTGSRASKVRVAPLAPSPAAMEVQGKV-PINR- 275
            .|.:...|.:.........|.|.||.|......:......:..|.      :|..:.|. ||.:
Yeast   195 AASIVKKEQLSGFENFLPLSKTESPLVTADEIKSSLNLENIDNAD------SMSFKLKTSPIRKH 253

  Fly   276 --VQPK-VKEVK--RSAHNAIERRYRTSINDKINELKNLV------------------------- 310
              |:|| :..|:  |.:||.||::||::|||||.:|:..|
Yeast   254 FHVKPKRITRVRTGRVSHNIIEKKYRSNINDKIEQLRRTVPTLRVAYKKCNDLPITSRDLADLDG 318

  Fly   311 VGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMARDG-------------SKVKDL 362
            :....||||:::|.|||:.|..|:|:...|....|.|..:  .||.             :...:.
Yeast   319 LEPATKLNKASILTKSIEYICHLERKCLQLSLANQHLSND--TRDSFVHLTEPSQPLSDNSSSEQ 381

  Fly   363 LQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDESDPSLSPMHSDISLPPSPYGGSTASCSSGSS 427
            :|..||..:..::|:              ||..:      |:|:.....|...|     ..||::
Yeast   382 VQKQTRSCQRQRQRQ--------------PRQQQ------PLHNIQYNIPHQNG-----LMSGTN 421

  Fly   428 SSNE 431
            :|::
Yeast   422 NSHD 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	26/83 (31%)
		OmpH	<289..>364	CDD:281871	28/112 (25%)
HMS1	NP_014675.1	bHLHzip_scHMS1_like	265..363	CDD:381405	30/99 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345454
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2588
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001476
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860