DRSC/TRiP Functional Genomics Resources

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Protein Alignment SREBP and TFEB

DIOPT Version :9

Sequence 1:NP_001262064.1 Gene:SREBP / 40155 FlyBaseID:FBgn0261283 Length:1113 Species:Drosophila melanogaster
Sequence 2:NP_001161299.2 Gene:TFEB / 7942 HGNCID:11753 Length:490 Species:Homo sapiens


Alignment Length:408 Identity:104/408 - (25%)
Similarity:163/408 - (39%) Gaps:86/408 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 QSVDQQPQSVEQQPHVKSEHSSPVHIKEELHQQQQQSPLLVYKPDPLIAT--SYNCPQQQPTGLL 130
            |.:.:|.|..||:..::.:  :.:|..::..|||||.  |...|.|.|.|  .:..|...|..:|
Human    24 QLMREQAQQEEQRERMQQQ--AVMHYMQQQQQQQQQQ--LGGPPTPAINTPVHFQSPPPVPGEVL 84

  Fly   131 KA----AQPTATIHHMDAQRMPPNTAVYPPSLGSSFVYQSMSP---PTSPVESANQNV---NVMQ 185
            |.    ..||:  :|:...:..........:.|:.|. ..:||   ...|..:|:..|   :|:.
Human    85 KVQSYLENPTS--YHLQQSQHQKVREYLSETYGNKFA-AHISPAQGSPKPPPAASPGVRAGHVLS 146

  Fly   186 PVAATPAPAS--APLPQQSYPQPFITYNSKAGMTSDEAMYFLLQPTVASPTPSP-------PVAP 241
            ..|...||.|  |.|...|.|:..:.......|..|:.:.: :.|.:..|...|       ..:.
Human   147 SSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGY-INPEMQMPNTLPLSSSHLNVYSS 210

  Fly   242 PPTSTGSRASKVRVAPLAPSPAAMEVQGKVPINRVQPKVKE-VKRSAHNAIERRYRTSINDKINE 305
            .|..|   ||.|.|.. :..||.:..:.::.....:...|| .|:..||.||||.|.:|||:|.|
Human   211 DPQVT---ASLVGVTS-SSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKE 271

  Fly   306 LKNLVVGE---QAKLNKSAVLRKSIDKIR----DLQR----QNHDLKAELQ------RLQR-ELM 352
            |..|:...   ..:.||..:|:.|:|.||    |||:    :||..:.|:.      |:|. |:.
Human   272 LGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQ 336

  Fly   353 AR---------DGSKVKDLLQLGTR--------PGRASKKRRESSQTFTTDAGLTPPRSDESDPS 400
            ||         .|..:.:|.|...:        ||.|          ....|.:..|   |..|:
Human   337 ARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEA----------LMLGAEVPDP---EPLPA 388

  Fly   401 LSPMHSDISL---PPSPY 415
            |.| .:.:.|   ||||:
Human   389 LPP-QAPLPLPTQPPSPF 405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SREBPNP_001262064.1 HLH 281..338 CDD:238036 27/68 (40%)
OmpH <289..>364 CDD:281871 33/101 (33%)
TFEBNP_001161299.2 MITF_TFEB_C_3_N 18..175 CDD:292573 39/157 (25%)
HLH 247..307 CDD:238036 24/59 (41%)
DUF3371 335..471 CDD:288684 19/85 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1708
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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