Protein Alignment SREBP and srebf1

DIOPT Version :9

• Sequence 1: NP_001262064.1
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_001098599.1
• Gene: srebf1 / 793274
• ZFINID: ZDB-GENE-090812-3
• Length: 1105
• Species: Danio rerio
• Alignment Length: 1198
• Identity: 378/1198 - (31%)
• Similarity: 554/1198 - (46%)
• Gaps: 197/1198 - (16%)

  Fly     2 DTTLMNLIDAPLDESMDLFKAEDVFEPFDADLHSDMLDII-LNDMDL------------APTQMY 53
            ||:|     ..||.|:.|....|:......|: .|||.:| ..||:.            ||.|
Zfish     7 DTSL-----DTLDSSLSLHDPSDIDTALLNDI-DDMLQLINTQDMEFGLFDQASFPAPAAPAQ-- 63

  Fly    54 NMLLDEPRTHTQQTQSVDQQPQS----VEQQPHVKSEHSSPVHIKEELHQQQ-------QQSPLL 107
                  .:.|:.........|.:    :...||:.:....|:.....:...:       ||:||.
Zfish    64 ------EQLHSSPASPAAAPPPAASSILSSSPHLDALLGPPITRSSSIPTDKAFQPHTFQQAPLA 122

  Fly   108 VYKPDPLIATSYNCPQQQPTGLLKAAQPTATIHHMDAQRMPPNTAVYP-PSLGSSF--------V 163
            .....| .|.....|:.||.       |:|::  ..:.:.||:.:..| .:|.||:        |
Zfish   123 QVNSTP-AALQTTQPKAQPA-------PSASL--QPSSQTPPSASSSPQQTLYSSYTTHTTYTPV 177

  Fly   164 YQSMSPPTSPVESAN-QNVNVM--QPVAATP------APASAPLPQQSYPQPFITYNSKAGMTSD 219
            .|..||.:.|..||: ||:..|  |.|:|:|      :|.:.|||.|....|.:.  ....:.:|
Zfish   178 TQQSSPQSIPSLSASPQNIQPMTIQSVSASPILTASSSPPTQPLPPQVQQLPVLL--QPQFIKAD 240

  Fly   220 EAMYFLLQP------TVASP-----TPSPPVAPPPTSTGSRASKVRVAPLAPSPAAMEVQGKVPI 273
            ..:...|:|      |||||     |.:.||...|.........:    |...|..::.: |:||
Zfish   241 SLLLTTLKPDVTMVTTVASPCITTLTSTAPVQNTPLQALMSGGTI----LTTVPLVVDTE-KLPI 300

  Fly   274 NRV--------QPKVKEVKRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKI 330
            ||:        ||. |..||:||||||:|||:||||||.|||:||.|.:|||||||||:|:|:.|
Zfish   301 NRIAISGKPGCQPH-KGEKRTAHNAIEKRYRSSINDKIIELKDLVAGTEAKLNKSAVLKKAIEYI 364

  Fly   331 RDLQRQNHDLKAELQRLQRELMARDGSKVKDL--LQLGTRPGRASKKRRESSQTFTTDAGLTPPR 393
            |.||:.|..||.|...|:..:  :....:|||  :::..:|...                 |||.
Zfish   365 RYLQQSNQKLKQENMALKMNI--QKNKSLKDLVTMEVDVKPEIP-----------------TPPA 410

  Fly   394 SDESDPSLS---PMHSDISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFM 455
            ||...|..|   ..||..|.|.||..              |:...|.....||...||:.||.|.
Zfish   411 SDVGSPQSSGPYSQHSSDSEPDSPMA--------------EDSKAVVERAGGMLDRSRMALCAFT 461

  Fly   456 FAILAVNPFKTFLQRGHYDSNDDLGDMSGQRRILSYDVEGEGFAVWQQSSW------IWLLNFTL 514
            ...|:.||..:.|..|...:...:...:..|.:||.:..||.   |....|      :||||..|
Zfish   462 LLFLSFNPLASLLCGGWSSAGASVPGNAAGRSVLSLEDSGES---WGWMDWMLPTLLVWLLNGVL 523

  Fly   515 MLGCLVKLLVYGDPQLDAQTDA---YCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRL 576
            :.|.|::|.|||:|.....:::   :..||:.||...::|..:||......||...|..||.|:|
Zfish   524 VAGVLIRLQVYGEPMTRPHSESSVLFWGHRKPADLDLARGDFAQASQNLRTCLKALGRPLPPSQL 588

  Fly   577 ECYLQTTWQFLRFLFHRLWLGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTGNGS 641
            :......|..||....|||:||.|:.|:|.|..|...::....|.|:.||:::||:||.:||...
Zfish   589 DLACAVLWSALRLCLQRLWVGRWLASRAGALRPNRPLQEDNCKSCRDAALVYHRLHQLHMTGKLG 653

  Fly   642 RGDMNGIMMALFASNMAEVAHNLLTPRETIC-IHVMTALRMKRSAPKWLQQLFARYYMSRARQEC 705
            ...::.|.|||.|.|:||.|.:.| |..|:. ::|..|||:|.|.|: |.....|.::|.|||.|
Zfish   654 GSHLSAIHMALSALNLAECAGDCL-PVATLAEVYVSAALRVKTSLPR-LLHFTTRVFLSSARQAC 716

  Fly   706 GLTRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLL 770
             |:.:......::|.....|:|:.....:|.   .|..::..:::..|..||.|.|.:.:|||||
Zfish   717 -LSPSGSVPPAMQWLCHPLGHRFFVDEDWTI---RSSPRESIYSQAGNSVDPLAQVTQGFREHLL 777

  Fly   771 FKAIQCLV----------GAGHKSGGLP-----TSSVSGEAEQLQQQQHSGTIVSNVLKYTSLLK 820
            .||:.|:.          |.|..|..|.     ||:........|    |..|.||:...|..
Zfish   778 EKALYCVAQPRGDKSLADGDGEFSDALEYLQLLTSAADAAGATTQ----SFAIGSNMATVTGC-- 836

  Fly   821 DTLWADEDERDTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPKALHAV 885
                      |.:..||:.::....:||.|||..||:||..::.:|..||..  ...||||...|
Zfish   837 ----------DPHSKWWSSMVVVVTNWLQGEDAAAERLYPAVEHLPRSLQSA--ESPLPKACVNV 889

  Fly   886 LRAKMILLKNNGNALDKSLKQLVNILCDESSVELQECLTVN-RITDAKGIKLLFQLLTCDWLLET 949
            .:|...||     |..:|.:..:: .|:.:||..::.|.:. ..:.:..:..|.|||.||.||.|
Zfish   890 FKAVRTLL-----AKPESQQPSLS-YCERASVLFRDSLNLGPHCSASTQLDKLVQLLLCDLLLVT 948

  Fly   950 RTALWELEHMNMEDDGFYQVPGEVLEKFQTDLNSLRNIVENIPNAQSRIYLYEAVCRLMAGASPC 1014
            ||.:|..:.:..........|.| |:.||.||:|||.:..:...|..|::|:||..||||||||.
Zfish   949 RTNVWRDQQVCSSSSTAAASPAE-LQGFQQDLSSLRRLAHSFRPATRRLFLHEATARLMAGASPT 1012

  Fly  1015 PTQQLLDRSLRSRNAHSSIFCGSKDRRQQNFVGGERERASAMYVACKYLPPALLSSPGERAGMLA 1079
            .|.||||||||.|....:..      .:.....|:||:|.|:.:||::|||:.||:||:|.||||
Zfish  1013 RTHQLLDRSLRRRATPGARI------EECELHPGQREQAEAVMLACRFLPPSFLSAPGQRVGMLA 1071

  Fly  1080 EAAKTLEKVGDKRKLKECYQLMKSLGNG 1107
            :||:||||:||||.|.:|.|::..||:|
Zfish  1072 DAARTLEKLGDKRTLHDCQQMIIKLGSG 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	39/56 (70%)
		OmpH	<289..>364	CDD:281871	42/76 (55%)
srebf1	NP_001098599.1	helix-Loop-helix DNA binding domain	315..372		39/56 (70%)
		HLH	315..372	CDD:238036	39/56 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2027
eggNOG	1	0.900	-	-		E1_KOG2588
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3079
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2483
OMA	1	1.010	-	-		QHG52391
OrthoDB	1	1.010	-	-		D167699at33208
OrthoFinder	1	1.000	-	-		FOG0001476
OrthoInspector	1	1.000	-	-		otm25465
orthoMCL	1	0.900	-	-		OOG6_104643
Panther	1	1.100	-	-	O	PTHR46062
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X2374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870