| Sequence 1: | NP_001262064.1 | Gene: | SREBP / 40155 | FlyBaseID: | FBgn0261283 | Length: | 1113 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_004590.2 | Gene: | SREBF2 / 6721 | HGNCID: | 11290 | Length: | 1141 | Species: | Homo sapiens |
| Alignment Length: | 1125 | Identity: | 350/1125 - (31%) |
|---|---|---|---|
| Similarity: | 525/1125 - (46%) | Gaps: | 132/1125 - (11%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 26 FEPFDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHTQQTQSVDQQPQSVEQQPHVKSEHSSP 90
Fly 91 VHIKEELHQQQQQSPLLVYKPDPLIATSYNCPQQQPTGLLKAA--QPTA---TIHHMDAQRMPPN 150
Fly 151 TAVYPPSLGSSFVYQSMSPPTSPVESANQNVNVMQPVAATPAPASAPLPQ-QSYP---QPFITYN 211
Fly 212 SKAGMTS-----DEAMYFLLQPTV-ASPTPSPPVA-PPPTSTGSRASKVRVAPLAPSPAAMEVQG 269
Fly 270 KVPINRVQPKVKEV-------KRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSI 327
Fly 328 DKIRDLQRQNHDLKAELQRLQRELMARDGSKVKDLLQLGTR-PGRASKKRRESSQTFTTDAGLTP 391
Fly 392 PRSDE-SDPSLSPMHSDISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFM 455
Fly 456 FAILAVNPFKTFLQRGHYDSNDDLGDMSGQRRILSYDVEGEGFAVWQQSS-WIWLLNFTLMLGCL 519
Fly 520 VKLLVYGDPQL---DAQTDAYCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYLQ 581
Fly 582 TTWQFLRFLFHRL----W-LGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTGNGS 641
Fly 642 RGD-MNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQEC 705
Fly 706 GLTRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLL 770
Fly 771 FKAIQCLV--GAGHKSGGLPTSSVS-GEAEQLQQQQHSGT----IVSNVLKYTSLLKDTLWADED 828
Fly 829 ERDTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPKALHAVLRAKMILL 893
Fly 894 KNNGNALDKSLKQLVNILCDESSVELQECLTVNRITDAKGIKLLFQLLTCDWLLETRTALWELEH 958
Fly 959 MNMEDDG-FYQVPGEVLEKFQTDLNSLRNIVENIPNAQSRIYLYEAVCRLMAGASPCPTQQLLDR 1022
Fly 1023 SLRSRNAHSSIFCGSKDRRQQNFVGGERERASAMYVACKYLPPALLSSPGERAGMLAEAAKTLEK 1087
Fly 1088 VGDKRKLKECYQLMKSLGNG 1107 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SREBP | NP_001262064.1 | HLH | 281..338 | CDD:238036 | 34/63 (54%) |
| OmpH | <289..>364 | CDD:281871 | 38/74 (51%) | ||
| SREBF2 | NP_004590.2 | Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956 | 1..50 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 48..144 | 12/50 (24%) | |||
| Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2 | 237..491 | 92/275 (33%) | |||
| HLH | 331..381 | CDD:278439 | 31/49 (63%) | ||
| Leucine-zipper | 380..401 | 8/23 (35%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 329 | 1.000 | Domainoid score | I1159 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG2588 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 416 | 1.000 | Inparanoid score | I1828 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S6888 |
| OMA | 1 | 1.010 | - | - | QHG52391 | |
| OrthoDB | 1 | 1.010 | - | - | D167699at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001476 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41314 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104643 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR46062 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1708 |
| SonicParanoid | 1 | 1.000 | - | - | X2374 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 15 | 14.820 | |||||