DRSC/TRiP Functional Genomics Resources

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Protein Alignment SREBP and SREBF1

DIOPT Version :9

Sequence 1:NP_001262064.1 Gene:SREBP / 40155 FlyBaseID:FBgn0261283 Length:1113 Species:Drosophila melanogaster
Sequence 2:NP_001005291.1 Gene:SREBF1 / 6720 HGNCID:11289 Length:1177 Species:Homo sapiens


Alignment Length:1223 Identity:391/1223 - (31%)
Similarity:541/1223 - (44%) Gaps:214/1223 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 NLIDAPLDESMDLFKAEDVFEPFDADLHSDMLDIILN-DMDLAPTQMYNMLLDEPRT-----HTQ 65
            |.:||| ....|....:..||        |||.:|.| |.|      :..|.|.|..     .|.
Human    41 NGLDAP-RAGADRGAMDCTFE--------DMLQLINNQDSD------FPGLFDPPYAGSGAGGTD 90

  Fly    66 QTQSVDQQPQSVEQQPHVKSEH-----SSPVHIKEELHQQQQQSPLLVYKPDPLIATSY-NCPQQ 124
            ........|.|:...|...|..     |.|         |...|||...:|.|.....| :.|..
Human    91 PASPDTSSPGSLSPPPATLSSSLEAFLSGP---------QAAPSPLSPPQPAPTPLKMYPSMPAF 146

  Fly   125 QP-TGLLKAAQPTATIHHMDAQRMP----PNT--AVYPPSLGSSFVYQSMSPPTSPVESANQNVN 182
            .| .|:.:.:.|.:.:.....|.:|    |.:  |..||...|:.|....||| ....:.:...|
Human   147 SPGPGIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPP-GGFSTGSPPGN 210

  Fly   183 VMQPVAATPAPASAPLP--------QQSYPQPFITYNS-------KAGMTSD-EAMYFLLQP--- 228
            ..||:...|..:...:|        |...||..:|..:       ...:||. :.:..||||   
Human   211 TQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLLQPHFI 275

  Fly   229 ---------------TVASPTPSPPVAPPPTSTGSRASKVRVAP-LAPSPAAMEVQGKVPINRV- 276
                           ||.:...||.|:.....||...:.|.... ||..|..::.: |:||||: 
Human   276 KADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDAE-KLPINRLA 339

  Fly   277 -------QPKVKEVKRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIRDLQ 334
                   ..:.:..||:||||||:|||:||||||.|||:||||.:|||||||||||:||.||.||
Human   340 AGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQ 404

  Fly   335 RQNHDLKAELQRLQRELMARDGSKVKDLLQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDESDP 399
            ..|..||.|  .|...........:|||:. ....|..:....|..:|...|. ||||.||...|
Human   405 HSNQKLKQE--NLSLRTAVHKSKSLKDLVS-ACGSGGNTDVLMEGVKTEVEDT-LTPPPSDAGSP 465

  Fly   400 SLSPMHSDISLPPSPYGGSTASCSSGSSSSNE-----------EPLVVPS-SMRGMATHSRLGLC 452
            ..|   |.:||      ||..|.|.||.|.:|           :|...|| ..|||...|||.||
Human   466 FQS---SPLSL------GSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSRGMLDRSRLALC 521

  Fly   453 MFMFAILAVNPFKTFLQRGHYDSNDDLGDM--SGQRRILSYDV-EGEGFAVWQQSSWIWLLNFTL 514
            ..:|..|:.||..:.|......|..|...:  |..|.:|..:. :|.|:|.|.....:||||..|
Human   522 TLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGWAQWLLPPVVWLLNGLL 586

  Fly   515 MLGCLVKLLVYGDPQLDAQTDA---YCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRL 576
            :|..||.|.|||:|.....:..   :.:||::||...::|..:||.......|...|..||.|.|
Human   587 VLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLPTSHL 651

  Fly   577 ECYLQTTWQFLRFLFHRLWLGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTGNGS 641
            :......|..:|.|..|||:||.|:.|:|||..:.|.|..|.||||:.||::::|:||...|..:
Human   652 DLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRVDASASARDAALVYHKLHQLHTMGKHT 716

  Fly   642 RGDMNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQECG 706
            .|.:....:||.|.|:||.|.:.::......|:|..|||:|.|.|:.|..| .|:::|.|||.| 
Human   717 GGHLTATNLALSALNLAECAGDAVSVATLAEIYVAAALRVKTSLPRALHFL-TRFFLSSARQAC- 779

  Fly   707 LTRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLLF 771
            |.::......::|.....|:|:.....::. ||...|  ..::...||.||.|.|.:.:|||||.
Human   780 LAQSGSVPPAMQWLCHPVGHRFFVDGDWSV-LSTPWE--SLYSLAGNPVDPLAQVTQLFREHLLE 841

  Fly   772 KAIQCLVGAGHKSGGLPTSSVSGEAEQLQQQQHSGTIVSNVLKYTSLLK---------------D 821
            :|:.|:.......|     |..|:.|           .|:.|.|..||.               .
Human   842 RALNCVTQPNPSPG-----SADGDKE-----------FSDALGYLQLLNSCSDAAGAPAYSFSIS 890

  Fly   822 TLWADEDERDTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPK-ALHAV 885
            :..|.....|....|||.:....:|||..::..||:|...::.:|..||:  ....||: |||:.
Human   891 SSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPLVEHLPRVLQE--SERPLPRAALHSF 953

  Fly   886 LRAKMILLKNNGNALDKSLKQLVNILCDESSVELQECLTVNRITDAKGIKLLFQLLTCDWLLETR 950
            ..|:.:|    |.|..:|....:.| |:::|..||:.|.....:.:  |....||..||.||..|
Human   954 KAARALL----GCAKAESGPASLTI-CEKASGYLQDSLATTPASSS--IDKAVQLFLCDLLLVVR 1011

  Fly   951 TALWELEHMNMEDDGFYQVPGEV----------------LEKFQTDLNSLRNIVENIPNAQSRIY 999
            |:||..:          |.|...                |..||.||:|||.:.::...|..|::
Human  1012 TSLWRQQ----------QPPAPAPAAQGTSSRPQASALELRGFQRDLSSLRRLAQSFRPAMRRVF 1066

  Fly  1000 LYEAVCRLMAGASPCPTQQLLDRSLRSRNAHSSIFCGSKDRRQQNFVGG----------ERERAS 1054
            |:||..||||||||..|.||||||||.|...     |.|        ||          .||.|.
Human  1067 LHEATARLMAGASPTRTHQLLDRSLRRRAGP-----GGK--------GGAVAELEPRPTRREHAE 1118

  Fly  1055 AMYVACKYLPPALLSSPGERAGMLAEAAKTLEKVGDKRKLKECYQLMKSLGNG 1107
            |:.:|..||||..||:||:|.|||||||:||||:||:|.|.:|.|::..||.|
Human  1119 ALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGG 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SREBPNP_001262064.1 HLH 281..338 CDD:238036 41/56 (73%)
OmpH <289..>364 CDD:281871 45/74 (61%)
SREBF1NP_001005291.1 CBP_CCPA 156..>356 CDD:293645 44/201 (22%)
HLH 351..408 CDD:238036 41/56 (73%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 329 1.000 Domainoid score I1159
eggNOG 1 0.900 - - E1_KOG2588
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3079
Inparanoid 1 1.050 416 1.000 Inparanoid score I1828
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52391
OrthoDB 1 1.010 - - D167699at33208
OrthoFinder 1 1.000 - - FOG0001476
OrthoInspector 1 1.000 - - otm41314
orthoMCL 1 0.900 - - OOG6_104643
Panther 1 1.100 - - O PTHR46062
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2374
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.840

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