Protein Alignment SREBP and MITF

DIOPT Version :9

• Sequence 1: NP_001262064.1
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_001341533.1
• Gene: MITF / 4286
• HGNCID: 7105
• Length: 526
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 115/539 - (21%)
• Similarity: 171/539 - (31%)
• Gaps: 200/539 - (37%)

  Fly    58 DEPRTHTQ------QTQSVDQQPQSVEQQPHVKSEHSSPVHIKEELHQQQQQSPLLVYKPDPLIA 116
            :||:|:.:      ::.|..:.| ...:.|...|..:|.:.::::|.::|.|......:...|.|
Human    19 EEPKTYYELKSQPLKSSSSAEHP-GASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQA 82

  Fly   117 TSY---NCPQQQ--------PTGLLKAAQ--------------PTATIHHMDAQRMPPNTAVYPP 156
            ..:   ..|..|        ||.|..|.|              || ..|...|||......: ..
Human    83 AQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPT-KYHIQQAQRQQVKQYL-ST 145

  Fly   157 SLGSSFVYQSMSPPTSPVESANQ-NVNVMQPVAATPAPASAPLPQQSYPQPFITYNSKAGMTSDE 220
            :|.:....|.:|.|     ..|| ..:||.||..:.||.|        |...:|.||..   ..|
Human   146 TLANKHANQVLSLP-----CPNQPGDHVMPPVPGSSAPNS--------PMAMLTLNSNC---EKE 194

  Fly   221 AMY-FLLQPTVASPTPSPPVAPPPTSTGSRAS----------------------------KVRVA 256
            ..| |..|....|..|.       .:|.||||                            .:::|
Human   195 GFYKFEEQNRAESECPG-------MNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMA 252

  Fly   257 PLAP--------------SPAAMEVQGKVPINRVQPKVK--------------------EVKRSA 287
            ...|              .|..:.:....|.|  .|.:|                    ..|:..
Human   253 NTLPVSGNLIDLYGNQGLPPPGLTISNSCPAN--LPNIKRELTACIFPTESEARALAKERQKKDN 315

  Fly   288 HNAIERRYRTSINDKINELKNLVV---GEQAKLNKSAVLRKSIDKIRDLQRQ------------- 336
            ||.||||.|.:|||:|.||..|:.   ....:.||..:|:.|:|.||.|||:
Human   316 HNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKK 380

  Fly   337 ----NHDLKAELQRLQRELMARDGSKV-------------------------KDLLQ-------- 364
                |..|...:|.|:.:..|...|.:                         :||||
Human   381 LEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCT 445

  Fly   365 ---------------LGTRPGRASKKRRESSQTFTTDAGLTPPRSD-ESDPSLSPMHSDISLPPS 413
                           |||        ..|::|.::....:.....| ..|.:|||:.....|..|
Human   446 TTLDLTDGTITFNNNLGT--------GTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSS 502

  Fly   414 PYGGSTASCSSGSSSSNEE 432
            ...|::.:.|..||.|.||
Human   503 VSPGASKTSSRRSSMSMEE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	26/96 (27%)
		OmpH	<289..>364	CDD:281871	31/119 (26%)
MITF	NP_001341533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		7/35 (20%)
		MITF_TFEB_C_3_N	56..194	CDD:318217	35/155 (23%)
		Transactivation	224..295		7/72 (10%)
		HLH	309..369	CDD:238036	25/59 (42%)
		Leucine-zipper. /evidence=ECO:0000305|PubMed:24631970	374..395		3/20 (15%)
		DUF3371	397..516	CDD:314681	20/126 (16%)
		DNA binding regulation	401..431		2/29 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..526		9/26 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940