Protein Alignment SREBP and Tfe3

DIOPT Version :9

• Sequence 1: NP_001262064.1
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_001258156.1
• Gene: Tfe3 / 317376
• RGDID: 1559642
• Length: 573
• Species: Rattus norvegicus
• Alignment Length: 541
• Identity: 126/541 - (23%)
• Similarity: 192/541 - (35%)
• Gaps: 146/541 - (26%)

  Fly    85 SEHSSPVHIKEELHQQQQQ-------------SPLLVYKPDPLIAT---------------SYNC 121
            |..||.|.::::|.:.|.|             :|.    |.|..|:               |...
  Rat   107 SSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPF----PSPAPASPAISVIGVSAGGHTLSRPP 167

  Fly   122 PQQQPTGLLKA----AQPTATIHHMDAQRMPPNTAVYPPSLGSSFVYQSMSPPTSPVESANQNVN 182
            |.|.|..:||.    ..||.  :|:...|..........:||.....|:::||..|  |:.|.:.
  Rat   168 PAQVPREVLKVQTHLENPTR--YHLQQARRQQVKQYLSTTLGPKLASQALTPPPGP--SSAQPLP 228

  Fly   183 VMQPVAATPAPASAPLPQQSYPQPFITYNSKA---------------GMTSDEAMYFLLQPTVAS 232
            ..:...||....|||    :.|...:|..|.:               ...:||.:.:|...|...
  Rat   229 APETAHATGPTGSAP----NSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTAGL 289

  Fly   233 PTPSP-PVA----PPPTSTGSRASKVRVAPLAPSPAAMEVQGKVPINRVQPKVKE-VKRSAHNAI 291
            ..||. ||:    ...:|.|.....:.|:...|:... .::.::.....:..:|| .|:..||.|
  Rat   290 QLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELP-NIKREISETEAKALLKERQKKDNHNLI 353

  Fly   292 ERRYRTSINDKINELKNLVV---GEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMA 353
            |||.|.:|||:|.||..|:.   ..:.:.||..:|:.|:|.||.||::....| :|:..||.|..
  Rat   354 ERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKEQQRSK-DLESRQRSLEQ 417

  Fly   354 RDGS---KVKDL--------LQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDESDPSLSPMHSD 407
            .:.|   ::::|        |.:...||.                 |:...|..|| ||.|...|
  Rat   418 ANRSLQLRIQELELQAQIHGLPVPPNPGL-----------------LSLATSSVSD-SLKPEQLD 464

  Fly   408 ISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFMFAILAVNPFKTFLQRGH 472
            |.....|  .:|....||..:.|..|...|:.                       |..|.|.. |
  Rat   465 IEEEGRP--STTTFHVSGGPTQNAPPQQPPAP-----------------------PSDTLLDL-H 503

  Fly   473 YDSNDDLGDMS-----GQRRILSYDVEGEGFAVWQQSSWIWLLNFTLMLGCLVKLLVYGDPQLDA 532
            :.| |.|||:.     |...||   :|.||..            ..|..|.|..|....||.|.:
  Rat   504 FPS-DHLGDLGDPFHLGLEDIL---MEEEGMV------------GGLSGGALSPLRAASDPLLSS 552

  Fly   533 QTDAYCQHRQRADFYFSQGQS 553
            .:.|..:...|...:..:.:|
  Rat   553 VSPAVSKSSSRRSSFSMEDES 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	26/60 (43%)
		OmpH	<289..>364	CDD:281871	29/88 (33%)
Tfe3	NP_001258156.1	MITF_TFEB_C_3_N	112..264	CDD:292573	34/163 (21%)
		HLH	343..403	CDD:238036	25/59 (42%)
		DUF3371	431..571	CDD:288684	43/199 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910