DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SREBP and sre2

DIOPT Version :9

Sequence 1:	NP_001262064.1	Gene:	SREBP / 40155	FlyBaseID:	FBgn0261283	Length:	1113	Species:	Drosophila melanogaster
Sequence 2:	NP_595229.1	Gene:	sre2 / 2541044	PomBaseID:	SPBC354.05c	Length:	793	Species:	Schizosaccharomyces pombe

Alignment Length:	595	Identity:	138/595 - (23%)
Similarity:	204/595 - (34%)	Gaps:	195/595 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SMDLFKAEDVFEPFDADLHSDMLD---IILNDMD------LAPTQMYNMLLDEPRTHTQQTQSV- 70
            |||   |...|     :|:.|:.|   :..|.:|      |.|.:. |....:.:.|::|..|.
pombe    87 SMD---ASTAF-----NLNQDVADKPMLARNSIDSSINTELGPLES-NHWFTQAQDHSRQYSSSW 142

  Fly    71 --------------DQQPQSVEQQPHVKSEHSSPV--HIKEELHQQQQQSPLLVYKPDPLIATSY 119
                          |....|:...||:...|....  |..|.|  |..|.|:...|...|..|..
pombe   143 DPSIDPFEVKNSLHDSTDLSITHHPHLPINHQGNTWKHANESL--QSNQGPVPNTKFVGLETTQT 205

  Fly   120 NCPQQQPTG---LLKAAQPTATIHHMDAQ----RMPPNTAVYPPSLGSSFVYQSMSPPTSPVESA 177
            :..||....   .::.|..|..:.....|    ....|.::.|.||..:|...:..|..:.::|.
pombe   206 DSYQQSSVNSVVKIEEADATYALREESGQFNTFTGAENPSISPHSLNPNFPQYTEKPALTLLQSP 270

  Fly   178 NQNVNV-MQPVAATPAPASAPLPQQSYPQPFITYNSKAGMTSDEAMYF-LLQPTVASPTPSP--- 237
            .||.|. ......:.:.:|.....:..|.|.     |..|:||:|:.| ..|.:...|..:|
pombe   271 KQNSNYDTSNFQNSVSDSSMQFTNEGMPSPV-----KGIMSSDDAVAFNFSQYSTVYPQNAPENG 330

  Fly   238 -----------PVAPPPTSTGSRASKVRVA--------------PL-APSPAAMEVQGKV----- 271
                       .|:.|..|..|:.|...:|              |. :||.::..|:|.|
pombe   331 NEFETPNKLKRTVSSPCASISSKRSYGDIAQDCSYISSKTNGGGPSDSPSSSSTSVRGSVNDSNS 395

  Fly   272 PI----------NRVQP---KVKE------VKRSAHNAIERRYRTSINDKI-------------- 303
            ||          |.|:|   ..:|      .||||||.||:|||:::||||
pombe   396 PISSSATFAIQSNGVEPVGLSTQEQNLSPLSKRSAHNMIEKRYRSNLNDKIAELRDAVPTLRSGY 460

  Fly   304 -----NELKNLVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMARDGSKVKDLL 363
                 :|||...|....||||:.:|.|:.:.|:.||.:|..|..|.:.||:.|     |:...::
pombe   461 NSTTADELKGTYVPLSRKLNKATILSKATEYIKSLQSKNKKLIEENKILQKRL-----SEYTSVI 520

  Fly   364 QL-----------------GTRPG--------RASKKRRESSQTFTTDA----GLTPPRSDESDP 399
            |.                 |..||        :.|.....|.|.:..||    ...|..|....|
pombe   521 QASLTAPSQPASLSLLGPPGNTPGHRNVPPILKRSSIGTPSQQAYFPDAPHNCHSVPQNSSYPRP 585

  Fly   400 SL----SPMHSDISLP---------------------------------PSPYGGSTASCSSGSS 427
            .:    ||:.|..::|                                 |..||||..| |:..|
pombe   586 PMQVNRSPIDSMQTIPHANFNEMHNAYSSRYPLKYSKSCNAVSHTSMMHPQEYGGSLPS-STVPS 649

  Fly   428 SSNEEPLVVP 437
            ..|:..||.|
pombe   650 DYNQPQLVSP 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	29/81 (36%)
SREBP	NP_001262064.1	OmpH	<289..>364	CDD:281871	30/93 (32%)
sre2	NP_595229.1	HLH	427..496	CDD:278439	26/68 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	48	1.000	Domainoid score	I3486
eggNOG	1	0.900	-	-		E1_KOG2588
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001476
OrthoInspector	1	1.000	-	-		otm47246
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930