Protein Alignment SREBP and sre1

DIOPT Version :9

• Sequence 1: NP_001262064.1
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_595694.1
• Gene: sre1 / 2540730
• PomBaseID: SPBC19C2.09
• Length: 900
• Species: Schizosaccharomyces pombe
• Alignment Length: 1055
• Identity: 198/1055 - (18%)
• Similarity: 359/1055 - (34%)
• Gaps: 386/1055 - (36%)

  Fly   148 PP---NTAVYPPSLGSSFVYQSMS---------------PP---TSPVESANQNVNVMQPVAATP 191
            ||   ||::.|.|...|.:..|||               ||   ::.:.|.|...|...|:.:..
pombe    73 PPTLTNTSLSPHSFSLSDMESSMSNWLNPFAFDNTMNSAPPLFTSTNMGSPNSLENSTNPLLSNC 137

  Fly   192 APASA----------------------------------PLPQQSYPQPFITYNSKAGMTSDEAM 222
            ...::                                  |...|:||...:: |.:..:.::|
pombe   138 GSPNSFQNETFTGPSLNEFDADDKIQRQMKILHSVDTIDPSTVQNYPSADMS-NPEVKLKTEE-- 199

  Fly   223 YFLLQP--TVASPTPS----------------PPVAP--PPTSTGSRASKVRVAPLAPSPAAMEV 267
              ::.|  |...|.||                |...|  .|.|.||         |:||.....|
pombe   200 --IITPMDTTCKPEPSAKKIKLSPSSEDSCSIPETLPFSAPKSRGS---------LSPSETPDFV 253

  Fly   268 QGKVPINRVQPKVKEVKRSAHNAIERRYRTSINDKINELKNLVVGEQA----------------- 315
            .|        |..|. |::|||.||:||||::||:|.||::.|...:|
pombe   254 AG--------PGGKP-KKTAHNMIEKRYRTNLNDRICELRDAVPSLRAAAALRCGNSLDDEDLGG 309

  Fly   316 -----KLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMARDGSKVKDLLQLGTRPGRASKK 375
                 ||||..:|.|:.:.||.|:.:|    .|||:..::|..|
pombe   310 LTPARKLNKGTILAKATEYIRHLEAKN----KELQKTNKQLSDR--------------------- 349

  Fly   376 RRESSQTFTTDAGLTPPRSDESDPSLSPMHSDISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSM 440
                 ..|..|..:.||.:|     ...::|...:..|.|....:|..:.:..:...|.:  ::|
pombe   350 -----LAFYEDPSMAPPSND-----TRAVNSVNVVSSSDYSVHQSSRPNLTQRAFTSPTL--NTM 402

  Fly   441 RGMATHSRLGLCMFMFAILAVNPFKTFLQRGHYDSNDDLGDMSGQRRILSYDVEGEGFAV--WQQ 503
            ...|.:..:||.:|                 :|..||....:.|.            ||:  :..
pombe   403 GRTALNGMVGLGLF-----------------NYFGNDSSQSVYGL------------FALPPFLM 438

  Fly   504 SSWIWLLNFTLM-LGCLVKLLVY------------GDPQLDAQTDAYCQHRQRADFYFSQGQSSQ 555
            |.:...:.|.:: :|.::..|.|            |:.:....|                 :||.
pombe   439 SPFTGTVLFNMLKIGVVLLGLFYLLHDNSLFKGFKGEKKSKVST-----------------RSSM 486

  Fly   556 AYAGYLNCLHMFGLSLPASRLECYLQTTWQFLRFLFH-----RLWLGRV----------LSRRSG 605
            :               |:|.|  :.:|.::....|.|     .|:.|.:          |:.|..
pombe   487 S---------------PSSIL--FRKTVFEKYCLLDHSTSTISLFFGLLIFTLKSAYGYLTHRLS 534

  Fly   606 GLFSNAAS---RKQALASARELALLFNRLNQLQLTGNGSRGDMNGIMMALFASNMAEVAHNLLTP 667
            .|::::.:   .:|.||..|.:    .:|...||.|..::.|...::| :|||:.:      |.|
pombe   535 ALYTSSENWVYSEQQLAEVRNM----EKLLDAQLMGGDAKVDRLRLLM-VFASSFS------LPP 588

  Fly   668 RETIC-IHVM--TALRMKRSAPKWLQQLFARYYMSRARQECGLTRATEQTQELRWAFTAYGYRYC 729
            ....| :..|  ..:....|.|..:......::.:.|:::...:....:.:||         ..|
pombe   589 SSHTCALQAMYCQLIFSNTSVPSAIVSKCVAFFWNAAKKQHSKSSVHAELREL---------PEC 644

  Fly   730 ATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLLFKAIQCLVGAGHKSGGLPTSSVSG 794
                 |.:|.::...|..|         :.:::::     |:...:|...:...|..:.:|
pombe   645 -----TANLIENSHADDVF---------SPNMVER-----LWVLAKCTRDSAQMSDSIISS---- 686

  Fly   795 EAEQLQQQQHSGTIVSNVLKYTSLLKDTLWADEDERDTNVVWW-ADVLETAVHWLLGEDTLAEQL 858
                          :|:||..:.|            :....|: ||:|:.    ||.| :|:.::
pombe   687 --------------LSDVLVLSPL------------EVLASWYAADLLDA----LLME-SLSRKV 720

  Fly   859 YGRIKQMPTQLQQCGENDHLPKALHAVLRAKMILL-KNNGNALDKSLKQLVNI--LCDESSVELQ 920
              .|.::...:..|.:|..:.:  ||:| ||::|. :|..::|::.|....|.  ||.:...:..
pombe   721 --EISEIEEIISLCPKNSSIIR--HALL-AKLVLFPENTADSLNEVLAAYKNTLDLCSQDKRKQS 780

  Fly   921 ECLTVNRITDAKGIKLLFQLLTCDWLLETRTALWELEHMNMEDDGFYQ---VPGEVLEKFQTDLN 982
            ..|.:|       :..||.|.:|..|...|....::...      .||   ||..     ..|:.
pombe   781 SVLKIN-------LSKLFTLHSCLSLALQRLGYGDVSKR------MYQEIFVPDS-----DADIT 827

  Fly   983 SLRNIV----------------ENIPNAQSRIYLYEAVCRLMAGASPCPTQQLLDRSLRSRNAHS 1031
            .|..|:                ||....:..:|:..|:          .|.::.|..|..:..:|
pombe   828 PLSFIISWTALNTFAPICTSPKENDVVEKMAMYVRTAI----------GTLKIQDLKLSRKLINS 882

  Fly  1032 SIFCGSKDRRQQNFV 1046
            .|..||:.:....:|
pombe   883 CIDIGSRLQEDLGYV 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	27/78 (35%)
		OmpH	<289..>364	CDD:281871	29/96 (30%)
sre1	NP_595694.1	HLH	261..333	CDD:278439	25/71 (35%)
		DUF2014	517..766	CDD:286510	58/327 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2588
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001476
OrthoInspector	1	1.000	-	-		otm47246
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930