DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SREBP and Tfe3

DIOPT Version :9

Sequence 1:NP_001262064.1 Gene:SREBP / 40155 FlyBaseID:FBgn0261283 Length:1113 Species:Drosophila melanogaster
Sequence 2:NP_766060.2 Gene:Tfe3 / 209446 MGIID:98511 Length:572 Species:Mus musculus


Alignment Length:544 Identity:129/544 - (23%)
Similarity:196/544 - (36%) Gaps:153/544 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 SEHSSPVHIKEELHQQQQQ-------------SPLLVYKPDPLIAT---------------SYNC 121
            |..||.|.::::|.:.|.|             :|.    |.|..|:               |...
Mouse   107 SSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPF----PSPAPASPAISVIGVSAGGHTLSRPP 167

  Fly   122 PQQQPTGLLKA----AQPTATIHHMDAQRMPPNTAVYPPSLGSSFVYQSMSPPTSPVESANQNVN 182
            |.|.|..:||.    ..||.  :|:...|..........:||.....|:::||..|  |:.|.:.
Mouse   168 PAQVPREVLKVQTHLENPTR--YHLQQARRQQVKQYLSTTLGPKLASQALTPPPGP--SSAQPLP 228

  Fly   183 VMQPVAATPAPASAPLPQQSYPQPFITYNSKA---------------GMTSDEAMYFLLQPTVAS 232
            ..:...||....|||    :.|...:|..|.:               ...:||.:.:|...|...
Mouse   229 APETAHATGPTGSAP----NSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTAGL 289

  Fly   233 PTPSP-PVA----PPPTSTGSRASKVRVAPLAPSPAAMEVQGKVPINRVQPKVKE-VKRSAHNAI 291
            ..||. ||:    ...:|.|.....:.|:...|:... .::.::.....:..:|| .|:..||.|
Mouse   290 QLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELP-NIKREISETEAKALLKERQKKDNHNLI 353

  Fly   292 ERRYRTSINDKINELKNLVV---GEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMA 353
            |||.|.:|||:|.||..|:.   ..:.:.||..:|:.|:|.||.||::....| :|:..||.|..
Mouse   354 ERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKEQQRSK-DLESRQRSLEQ 417

  Fly   354 RDGS---KVKDL--------LQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDESDPSLSPMHSD 407
            .:.|   ::::|        |.:...||..|         .||        |..|| ||.|...|
Mouse   418 ANRSLQLRIQELELQAQIHGLPVPPNPGLLS---------LTT--------SSVSD-SLKPEQLD 464

  Fly   408 ISLPPSPYGGSTASCSSGSSSSN---EEPLVVPSSMRGMATHSRLGLCMFMFAILAVNPFKTFLQ 469
            |.....|   ||....||..:.|   ::|...||.                 |:|.:        
Mouse   465 IEEEGRP---STTFHVSGGPAQNAPPQQPPAPPSD-----------------ALLDL-------- 501

  Fly   470 RGHYDSNDDLGDMS-----GQRRILSYDVEGEGFAVWQQSSWIWLLNFTLMLGCLVKLLVYGDPQ 529
              |:.| |.|||:.     |...||   :|.||..            ..|..|.|..|....||.
Mouse   502 --HFPS-DHLGDLGDPFHLGLEDIL---MEEEGMV------------GGLSGGALSPLRAASDPL 548

  Fly   530 LDAQTDAYCQHRQRADFYFSQGQS 553
            |.:.:.|..:...|...:..:.:|
Mouse   549 LSSVSPAVSKASSRRSSFSMEEES 572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SREBPNP_001262064.1 HLH 281..338 CDD:238036 26/60 (43%)
OmpH <289..>364 CDD:281871 29/88 (33%)
Tfe3NP_766060.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 87..152 11/48 (23%)
MITF_TFEB_C_3_N 112..264 CDD:318217 34/163 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..248 12/43 (28%)
Strong transcription activation domain. /evidence=ECO:0000255 259..270 0/10 (0%)
HLH 343..403 CDD:238036 25/59 (42%)
Leucine-zipper 408..429 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 439..495 20/76 (26%)
DUF3371 <518..570 CDD:314681 15/66 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..572 9/53 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1708
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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