| Sequence 1: | NP_001262064.1 | Gene: | SREBP / 40155 | FlyBaseID: | FBgn0261283 | Length: | 1113 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_150087.1 | Gene: | Srebf2 / 20788 | MGIID: | 107585 | Length: | 1130 | Species: | Mus musculus |
| Alignment Length: | 1123 | Identity: | 344/1123 - (30%) |
|---|---|---|---|
| Similarity: | 525/1123 - (46%) | Gaps: | 132/1123 - (11%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 26 FEPFDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHTQQTQSVDQQPQSVEQQPHVKSEHSSP 90
Fly 91 VHIKEELHQQQQQSPLLVYKPDPLIATSYNCPQQQPTGLLKAAQPTATIHHMDAQRMPPNTAVYP 155
Fly 156 PSLGSSFVYQSMSPPTSPVESANQNVNVMQPVAATPAPASAPLPQ-QSYP---QPFITYNSKAGM 216
Fly 217 TSDEAMYFLLQPTVASPTPSPPVAP-------PPTSTGSRASKVRVAPLAPSPAAMEVQGKVPIN 274
Fly 275 RVQPKVKEV-------KRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIRD 332
Fly 333 LQRQNHDLKAELQRLQRELMARDGSKVKDLLQLGTR-PGRASKKRRESSQTFTTDAGLTPPRSDE 396
Fly 397 -SDPSLSPMHSDISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFMFAILA 460
Fly 461 VNPFKTFLQRG--HYDSNDDLGDMSGQ-RRILSYDVEGEGFAVWQ-QSSWIWLLNFTLMLGCLVK 521
Fly 522 LLVYGDPQL---DAQTDAYCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYLQTT 583
Fly 584 WQFLRFLFHRL----WLGRVLSRRSGGLFSNAAS-RKQALASARELALLFNRLNQLQLTGNGSRG 643
Fly 644 D-MNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQECGL 707
Fly 708 TRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLLFK 772
Fly 773 AIQCLV--GAGHKSGGLPTSSVS-GEAEQLQQQQHSGT----IVSNVLKYTSLLKDTLWADEDER 830
Fly 831 DTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPKALHAVLRAKMILLKN 895
Fly 896 NGNALDKSLKQLVNILCDESSVELQECLTVNRITDAKGIKLLFQLLTCDWLLETRTALWELEHMN 960
Fly 961 MEDDG-FYQVPGEVLEKFQTDLNSLRNIVENIPNAQSRIYLYEAVCRLMAGASPCPTQQLLDRSL 1024
Fly 1025 RSRNAHSSIFCGSKDRRQQNFVGGERERASAMYVACKYLPPALLSSPGERAGMLAEAAKTLEKVG 1089
Fly 1090 DKRKLKECYQLMKSLGNG 1107 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SREBP | NP_001262064.1 | HLH | 281..338 | CDD:238036 | 34/63 (54%) |
| OmpH | <289..>364 | CDD:281871 | 38/74 (51%) | ||
| Srebf2 | NP_150087.1 | Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956 | 1..50 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 53..133 | 9/44 (20%) | |||
| Interaction with LMNA. /evidence=ECO:0000269|PubMed:11929849 | 226..480 | 90/275 (33%) | |||
| HLH | 320..370 | CDD:278439 | 31/49 (63%) | ||
| Leucine-zipper | 369..390 | 8/23 (35%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 332 | 1.000 | Domainoid score | I1142 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG2588 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 417 | 1.000 | Inparanoid score | I1796 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S6888 |
| OMA | 1 | 1.010 | - | - | QHG52391 | |
| OrthoDB | 1 | 1.010 | - | - | D167699at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001476 | |
| OrthoInspector | 1 | 1.000 | - | - | otm43373 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104643 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR46062 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1708 |
| SonicParanoid | 1 | 1.000 | - | - | X2374 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 15 | 14.820 | |||||