DRSC/TRiP Functional Genomics Resources

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Protein Alignment SREBP and Mycn

DIOPT Version :9

Sequence 1:NP_001262064.1 Gene:SREBP / 40155 FlyBaseID:FBgn0261283 Length:1113 Species:Drosophila melanogaster
Sequence 2:NP_032735.3 Gene:Mycn / 18109 MGIID:97357 Length:462 Species:Mus musculus


Alignment Length:303 Identity:65/303 - (21%)
Similarity:104/303 - (34%) Gaps:101/303 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 AAQPTATIHHMDAQRMPPNTAVYPPSLGSSFVYQSMSPPTSPVESANQNVNVMQPVAATPAPASA 196
            |..|| .:.|..|:.:.| ..|:|..:...   :|.|.|.:|..:...:.    .|.:...||:|
Mouse   174 ATLPT-DLSHPAAECVDP-AVVFPFPVNKR---ESASVPAAPTSAPATSA----AVTSVSVPATA 229

  Fly   197 PL--PQQSYPQPFITYNSKAGMTSDE--------------------------------------A 221
            |:  |.::..:|..:..:||..||.|                                      .
Mouse   230 PVAAPARAGGRPASSGEAKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNNKAVTT 294

  Fly   222 MYFLLQPTV-------ASP------------------TPSPPV----APPPTSTGSRASKVRVAP 257
            ....::|..       |.|                  .|||.|    |||.....|.||      
Mouse   295 FTITVRPKTSALGLGRAQPGELILKRCVPIHQQHNYAAPSPYVESEDAPPQKKIKSEAS------ 353

  Fly   258 LAPSPAAMEVQGKVPINRVQPKVKE----VKRSAHNAIERRYRTSINDKINELKN----LVVGEQ 314
              |.|....|..|.  ..:.|:..:    .:|..||.:||:.|..:......|::    ||..|:
Mouse   354 --PRPLKSVVPAKA--KSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEK 414

  Fly   315 AKLNKSAVLRKSIDKIRDLQRQNHDL---KAELQRLQRELMAR 354
            |.  |..:|:|:.:.:..||...|.|   |.:||..|::|:.:
Mouse   415 AA--KVVILKKATEYVHALQANEHQLLLEKEKLQARQQQLLKK 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SREBPNP_001262064.1 HLH 281..338 CDD:238036 16/64 (25%)
OmpH <289..>364 CDD:281871 21/73 (29%)
MycnNP_032735.3 Myc_N 10..370 CDD:279405 41/214 (19%)
Interaction with AURKA. /evidence=ECO:0000250|UniProtKB:P04198 19..47
Interaction with AURKA and FBXW7. /evidence=ECO:0000250|UniProtKB:P04198 61..90
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 134..177 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 232..289 7/56 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..390 19/67 (28%)
HLH 377..436 CDD:238036 16/60 (27%)
Leucine-zipper 431..452 8/20 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2588
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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