Protein Alignment SREBP and sbp-1

DIOPT Version :9

• Sequence 1: NP_001262064.1
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_499472.1
• Gene: sbp-1 / 176574
• WormBaseID: WBGene00004735
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 1172
• Identity: 253/1172 - (21%)
• Similarity: 445/1172 - (37%)
• Gaps: 287/1172 - (24%)

  Fly    27 EPFDAD--LHSDMLDIILNDMDLAPTQMYNMLLDEPRTHTQQTQSVDQQPQSVEQQPHVKSEHSS 89
            |.|:.|  :....|.::....|:||.. .|..||....|..|.....|||     .|.:.....|
 Worm     3 EEFEGDVPMSDPFLSLVTKLDDIAPFP-NNDPLDFDMEHNWQEPGPSQQP-----DPSIPGNQHS 61

  Fly    90 PVHIKEELHQQQQQSPL-------------LVYKP---------DPLIATSYNCPQQQPTGLLK- 131
            |.....::..|:..|.|             :.:.|         .|.:|.:.....:.|..:|.
 Worm    62 PPQEYYDIDGQRDVSTLHSLLNHNNDDFFSMRFSPPNFDLGGGRGPSLAATQQLSGEGPASMLNP 126

  Fly   132 --------------AAQPTATIHHMDAQRMPPNTA--VYPPSLG---SSFVYQSMSPP--TS--- 172
                          |.:|.:....:.|..|.|:.|  ::..:.|   .:|.:..:|||  ||
 Worm   127 LQTSPPSGGYPPADAYRPLSLAQQLAAPAMTPHQAASLFVNTNGIDQKNFTHAMLSPPHHTSMTP 191

  Fly   173 -PVESANQNVN-VMQPVAATPAPA---------SAPLP--QQSYPQPFITYNSKAGMTSDEAMYF 224
             |...|.:::| .|.|......|:         .:|.|  ...:|.|.|..|.:
 Worm   192 QPYTEAMEHINGYMSPYDQAQGPSGPSYYSQHHQSPPPHHHHHHPMPKIHENPE----------- 245

  Fly   225 LLQPTVASPT--------------PSPPVAPP--------------------------------- 242
                .||||:              |..|.:|.
 Worm   246 ----QVASPSIEDAPETKPTHLVEPQSPKSPQNMKEELLRLLVNMSPSEVERLKNKKSGACSATN 306

  Fly   243 -PTSTGSRASKVRVAPLA-----------PSPAAMEVQGKVPINRVQPKVKEVKRSAHNAIERRY 295
             |:.:..:|:|:.:...|           .|...|. ||...|.| :||.:  :|:|||.||::|
 Worm   307 GPSRSKEKAAKIVIQETAEGDEDEDDEDSDSGETMS-QGTTIIVR-RPKTE--RRTAHNLIEKKY 367

  Fly   296 RTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMARDGSKVK 360
            |.||||:|.:||.|:.|::|||:|||.||::|:.|.:::.:|..||..::::::
 Worm   368 RCSINDRIQQLKVLLCGDEAKLSKSATLRRAIEHIEEVEHENQVLKHHVEQMRK----------- 421

  Fly   361 DLLQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDESDPSLSPMHSDISLPPSPYGGSTASCSSG 425
             .||....|.....:..|.|.....::..:|||::.....:|               :|....:|
 Worm   422 -TLQNNRLPYPEPIQYTEYSARSPVESSPSPPRNERKRSRMS---------------TTTPMKNG 470

  Fly   426 SSSSNEEPLVVPSSMRGMATHSRLGLCMFMFAILAVNPFKTFLQRGHYDSNDDLGDMSGQR---- 486
            :...:                |::.|...:.|:|..||               :|.::|..
 Worm   471 TRDGS----------------SKVTLFAMLLAVLIFNP---------------IGLLAGSAIFSK 504

  Fly   487 --------------RILSYDVEGEGFAV--WQQS----SWIWLLNFTLMLGCLVKLLVYGDPQLD 531
                          |::. |.:|.....  |:.|    |::|:.|..:::..:||||::|||..|
 Worm   505 AAAEAPIASPFEHGRVID-DPDGTSTRTLFWEGSIINMSYVWVFNILMIIYVVVKLLIHGDPVQD 568

  Fly   532 AQT---DAYCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYLQTTWQFLRFLFHR 593
            ..:   ..:...|::|....:.|....|...:..||.....|||:..::......|:.:|.|.:.
 Worm   569 FMSVSWQTFVTTREKARAELNSGNLKDAQRKFCECLATLDRSLPSPGVDSVFSVGWECVRHLLNW 633

  Fly   594 LWLGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTG-NGSRGD------MNGIMMA 651
            ||:||.::||..   |..........|..:.|:|::.::||.|.| .|:..|      :.|:.|:
 Worm   634 LWIGRYIARRRR---STTKPVSVVCRSHAQTAVLYHEIHQLHLMGITGNFEDTYEPSALTGLFMS 695

  Fly   652 LFASNMAEV--AHNLLTPRETIC-IHVMTALRMKRSAPKWLQQLFARYYMSRARQECGLTRATEQ 713
            |.|.|:||.  |.|...||..:. |::..:::.:.:.|..|...|:.|::.|||:.  :.||.|.
 Worm   696 LCAVNLAEAAGASNDGLPRAVMAQIYISASIQCRLALPNLLAPFFSGYFLRRARRH--VRRAPEH 758

  Fly   714 T-QELRWAFTAYGYRYCATHVFTYD-------LSDSGEQDGFFTRLRN-PCDPAAHVIKQYREHL 769
            : ..|.|.|      :.||..|..|       ||...:|..|.:.:.: ...|.|.:....:.:|
 Worm   759 SVSHLLWIF------HPATRKFMSDAKRLEHVLSSKQKQLRFGSFVEDEQLSPLARIRTTLKVYL 817

  Fly   770 LFKAIQCLVGAGHKSGGLPTSSVSGEAEQLQQQQHSGTIVSNVLKYTSLLKDTLWADEDER---- 830
            |.|.:|.||| |.:........:..:.::|..:.....:...::..::.....|..::||.
 Worm   818 LSKLVQELVG-GDEIFTKNVERILNDNDRLDDEVDVVDVSRLLVTISTQCAAILTNEKDESAKFG 881

  Fly   831 -------DTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPKALHAVLRA 888
                   |....||..||...::|...::.||.|.|..|:..|.::.    .|:|..|:...|.|
 Worm   882 TWISRNGDACCTWWTHVLTCGIYWRSNKNELARQHYSLIRNCPPKIL----TDNLGLAVGHALCA 942

  Fly   889 KMILLKNNGNALDKSLKQLVNILCDESSVELQECLTVNRITD-AKGIKLLFQLLTCDWLLETRTA 952
            :.|.:.:..:   ..:.|.|.|...:|...|:...|.:|.:. ..||:...:.:..:|::.:...
 Worm   943 RKICIDDRDS---PKVSQYVCIHTKKSLESLRLFSTSSRASGVVSGIQEGTRRMAYEWIMNSLLD 1004

  Fly   953 LWELEHMNMEDDGFYQVPGEVLEKFQTDLNSLRN---IVENIPNAQSRIYLYEAVCRLMAGASPC 1014
            .|.......:........|:  ..|.|......|   |:........|:::||..||::.||:|.
 Worm  1005 AWRSNLFASKPYWTQSFKGQ--STFSTLYQEAYNHYAIINGTRGDCWRLFVYELTCRMLNGANPQ 1067

  Fly  1015 PT 1016
            .|
 Worm  1068 AT 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	27/56 (48%)
		OmpH	<289..>364	CDD:281871	27/74 (36%)
sbp-1	NP_499472.1	Atrophin-1	30..>272	CDD:367360	50/261 (19%)
		bHLH_SF	351..423	CDD:381792	32/85 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164595
Domainoid	1	1.000	121	1.000	Domainoid score	I3549
eggNOG	1	0.900	-	-		E1_KOG2588
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I2764
Isobase	1	0.950	-	0	Normalized mean entropy	S6888
OMA	1	1.010	-	-		QHG52391
OrthoDB	1	1.010	-	-		D167699at33208
OrthoFinder	1	1.000	-	-		FOG0001476
OrthoInspector	1	1.000	-	-		oto18261
orthoMCL	1	0.900	-	-		OOG6_104643
Panther	1	1.100	-	-	LDO	PTHR46062
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X2374
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750