Protein Alignment SREBP and Mitf

DIOPT Version :9

• Sequence 1: NP_001262064.1
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_001106669.1
• Gene: Mitf / 17342
• MGIID: 104554
• Length: 526
• Species: Mus musculus
• Alignment Length: 537
• Identity: 120/537 - (22%)
• Similarity: 175/537 - (32%)
• Gaps: 196/537 - (36%)

  Fly    58 DEPRTH----TQQTQSVDQQPQSVEQQPHVKSE-HSSPVHIKEELHQQQQQSPLLVYKPDPLIAT 117
            :||:|:    :|..:|......|...:|.:.|. .:|.:.::::|.::|.|......:...|.|.
Mouse    19 EEPKTYYELKSQPLKSSSSAEHSGASKPPLSSSTMTSRILLRQQLMREQMQEQERREQQQKLQAA 83

  Fly   118 SYNCPQQQ-------------PTGLLKAAQ--------------PTATIHHMDAQRMPPNTAVYP 155
            .:  .||:             ||.|..|.|              || ..|...|||......: .
Mouse    84 QF--MQQRVAVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPT-KYHIQQAQRHQVKQYL-S 144

  Fly   156 PSLGSSFVYQSMSP--PTSPVESANQNVNVMQPVAATPAPASAPLPQQSYPQPFITYNSKAGMTS 218
            .:|.:....|.:|.  |..|.:.|      |.||..:.||.|        |...:|.||..   .
Mouse   145 TTLANKHASQVLSSPCPNQPGDHA------MPPVPGSSAPNS--------PMAMLTLNSNC---E 192

  Fly   219 DEAMY-FLLQPTVASPTPSPPVAPPPTSTGSRAS----------------------------KVR 254
            .||.| |..|....|..|.       .:|.||||                            .::
Mouse   193 KEAFYKFEEQSRAESECPG-------MNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQ 250

  Fly   255 VAPLAP--------------SPAAMEVQGKVPINRVQPKVK--------------------EVKR 285
            :|...|              .|..:.:....|.|  .|.:|                    ..|:
Mouse   251 MANTLPVSGNLIDLYSNQGLPPPGLTISNSCPAN--LPNIKRELTACIFPTESEARALAKERQKK 313

  Fly   286 SAHNAIERRYRTSINDKINELKNLVV---GEQAKLNKSAVLRKSIDKIRDLQRQNHDLK------ 341
            ..||.||||.|.:|||:|.||..|:.   ....:.||..:|:.|:|.||.|||:....|
Mouse   314 DNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQ 378

  Fly   342 AELQRLQRELMARDGSKVKDL--------LQLGTRPG--------RASKKR-------------- 376
            .:|:...|.|:.|    |::|        |.|....|        |..|:.
Mouse   379 KKLEHANRHLLLR----VQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQELVQHQ 439

  Fly   377 -----------RESSQTFTTDAGLTP--------PRSDES-------DPSLSPMHSDISLPPSPY 415
                       .:.:.|||.:.|..|        ||...|       |.:|||:.....|..|..
Mouse   440 ADLTCTTTLDLTDGTITFTNNLGTMPESSPAYSIPRKMGSNLEDILMDDALSPVGVTDPLLSSVS 504

  Fly   416 GGSTASCSSGSSSSNEE 432
            .|::.:.|..||.|.||
Mouse   505 PGASKTSSRRSSMSAEE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	26/79 (33%)
		OmpH	<289..>364	CDD:281871	30/91 (33%)
Mitf	NP_001106669.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..54		8/33 (24%)
		MITF_TFEB_C_3_N	56..194	CDD:406384	34/158 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..179		8/29 (28%)
		Transactivation. /evidence=ECO:0000250	224..291		7/68 (10%)
		bHLHzip_MITF	300..403	CDD:381496	32/106 (30%)
		Leucine-zipper. /evidence=ECO:0000305|PubMed:23207919	374..395		5/24 (21%)
		DUF3371	397..522	CDD:403149	26/125 (21%)
		DNA binding regulation. /evidence=ECO:0000250	401..431		5/29 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..526		9/26 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940