DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SREBP and tfe3a

DIOPT Version :9

Sequence 1:	NP_001262064.1	Gene:	SREBP / 40155	FlyBaseID:	FBgn0261283	Length:	1113	Species:	Drosophila melanogaster
Sequence 2:	NP_571923.2	Gene:	tfe3a / 114834	ZFINID:	ZDB-GENE-010919-2	Length:	539	Species:	Danio rerio

Alignment Length:	554	Identity:	126/554 - (22%)
Similarity:	211/554 - (38%)	Gaps:	121/554 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TLMNLIDAPLDESMDLFKAEDVFEPFDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHTQQTQ 68
            |:..::|:.  ||::|...|.:...     ...:.||.:..:..|.:..:..|..:|.|.:....
Zfish    29 TVYVILDSA--ESVNLISVEPLLPE-----SGIVADIEVESVFSADSDAFYELKGQPITPSGSLT 86

  Fly    69 SVDQQPQSVEQQPHVKSEHSSPVHIKEELHQQQQQ-------------SPLLVYKPDPLIATSYN 120
            |.|....:       .|..:|.|.:::||.:||.|             :...:....|.|:.:.|
Zfish    87 SADPVTPT-------GSVMTSRVLMRQELMRQQAQDQERREAQKQASSAQQRLTDSTPAISVASN 144

  Fly   121 C---PQQQPTGLLKA----AQPTATIHHMDAQRMPPNTAVYPPSLGSSFVYQSM--SPPTSPVES 176
            .   |.|.|..:||.    ..|| ..|...|||......: ..:||:....|::  |||..|
Zfish   145 LPAKPTQVPVEVLKVQTHLENPT-KYHIQQAQRQQVKQYL-SHTLGNKIASQTLATSPPPQP--- 204

  Fly   177 ANQNVNVMQPVAATP--APASAPLPQQSYPQPFITYNSK--------------AGMTSDEAMYFL 225
                       ::.|  |||::..|  |.|...::..|.              ....:||.| .|
Zfish   205 -----------SSAPELAPAASSTP--SSPLAVLSLGSNKEEIEDVIDDIISLESSLNDEFM-TL 255

  Fly   226 LQPTVASPTPSP---PVAPPPTSTGSRASKVRVAPLAPSPAAMEVQGKVPINRVQPKVKE-VKRS 286
            :...:..|:..|   .:....:|.|..|..:.|:...|:. ...|:.::.....:..:|| .|:.
Zfish   256 IDSGLQLPSTLPVSGNLLDVYSSQGMAAPTITVSNSCPAD-LQNVKREMSDAEAKAIMKERQKKD 319

  Fly   287 AHNAIERRYRTSINDKINELKNLV---VGEQAKLNKSAVLRKSIDKIRDLQRQNHDLK------A 342
            .||.||||.|.:.||:|.||..|:   ...:.:.||..:|:.|:|.||.||::....|      .
Zfish   320 NHNLIERRRRFNTNDRIKELGALIPKSSDPELRWNKGTILKASVDYIRKLQKEQQRSKEMETRQK 384

  Fly   343 ELQRLQRELMARDGSKVKDLLQLGTRPGRASKKRRES---SQTFT------TDAGLTPPRSDESD 398
            :|:...|.||.|    :::|.......|.:|.:..:|   :||.|      ||...|.....::.
Zfish   385 KLEHANRSLMLR----IQELEMQARLHGLSSSQLSDSLTQTQTLTLEHNPNTDLSKTLLSITQTT 445

  Fly   399 PS--LSPMHSDISLPPSPYGGSTAS------CSSGSSSSNEEPLVVPSSMRGM----------AT 445
            ||  |||..|..|:     ||:..|      .|.|....:...:..|:.|..|          ..
Zfish   446 PSSFLSPPSSTSSV-----GGTVTSPLELGTLSFGELDDHTASVFSPALMADMGLGDILMDDSGA 505

  Fly   446 HSRLGLCMFMFAILAVNPFKTFLQRGHYDSNDDL 479
            .|.:|....:.:.::....||..:|..:...:||
Zfish   506 LSPVGGADPLLSAVSPGASKTSSRRSSFSMEEDL 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	25/60 (42%)
SREBP	NP_001262064.1	OmpH	<289..>364	CDD:281871	28/83 (34%)
tfe3a	NP_571923.2	MITF_TFEB_C_3_N	101..238	CDD:292573	35/154 (23%)
		HLH	314..374	CDD:238036	24/59 (41%)
		DUF3371	402..538	CDD:288684	29/140 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910