DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SREBP and mitfb

DIOPT Version :9

Sequence 1:	NP_001262064.1	Gene:	SREBP / 40155	FlyBaseID:	FBgn0261283	Length:	1113	Species:	Drosophila melanogaster
Sequence 2:	NP_571922.2	Gene:	mitfb / 114833	ZFINID:	ZDB-GENE-010919-1	Length:	500	Species:	Danio rerio

Alignment Length:	490	Identity:	125/490 - (25%)
Similarity:	177/490 - (36%)	Gaps:	140/490 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DEPRTHTQQTQSVDQQPQSVEQQPHVKSEHSS---PVH----------IKEELHQQ---QQQSPL 106
            :||:|:.:......|.....|||      |.|   |:.          ::|:|.||   :||...
Zfish    19 EEPKTYYELKSQPLQNSNPSEQQ------HGSCKPPLGSSRVLLRQQLMREQLQQQERREQQKRQ 77

  Fly   107 LVYKPDPLIATSYNC----PQQQPTGLLKA----AQPTATIHHMDAQRMPPNTAVYPPSLGSSFV 163
            :.....|.|..|:.|    ..|.|..:||.    ..|| ..|...|||.... |....:||..
Zfish    78 ISITHSPAINVSHPCGPPSAAQVPMEVLKVQTHLENPT-KYHIQQAQRQQVK-AYLSTTLGGK-- 138

  Fly   164 YQSMSPPTSPVESANQNVNVMQPVAATPAPASAPLPQQSYPQPFITYNSKA------------GM 216
             |::|.| .|.::::.  ..|.|.....||.|        |...:|.|...            |:
Zfish   139 -QAVSLP-CPSQASDH--GGMPPGPGNSAPNS--------PMALLTLNPNCEKEMDDVIDDIIGL 191

  Fly   217 T---SDEAMYFLLQP--TVASPTP---------SPPVAPPP------TSTGSRASKVRVAPLAPS 261
            .   ||:.|...|.|  .:|:..|         |.|..|||      :...:..|..|...:.||
Zfish   192 ESSYSDDIMGLSLDPGLQMANTIPVSANLLDMYSNPGLPPPGISISNSCPANMTSVKREFSVTPS 256

  Fly   262 PAAMEVQGK---------------VPIN-RVQPKVKE-VKRSAHNAIERRYRTSINDKINELKNL 309
            ||.|.:..|               .|:. .|:...|| .|:..||.||||.|.:|||:|.||..|
Zfish   257 PALMHMMDKPSSCSKFESYQRPEGFPVEVEVRALAKERQKKDNHNLIERRRRFNINDRIKELGTL 321

  Fly   310 VV---GEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQR----------------ELMARD 355
            :.   ....:.||..:|:.|:|.||.|||:.|..| ||:..|:                |:.||.
Zfish   322 IPKSNDPDMRWNKGTILKASVDYIRKLQREQHRTK-ELENRQKKLEHTNRNLLLRIQELEIQARA 385

  Fly   356 -----GSKVKDLLQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDE---------------SDPS 400
                 .|......:|..|..:......:.||...|.....|..:|.               ||..
Zfish   386 HGLAMASSALCASELAARAIKQEPLLGDCSQDMYTSTHAHPSCADMSRSSTLDLNNGTISFSDTH 450

  Fly   401 LSPMHS----DISLPPSPYGGSTASCSSGSSSSNE 431
            ||..|:    ||.:..:...|:|.. |..|::|||
Zfish   451 LSDTHAAKLDDILMDETLTSGATNE-SLISAASNE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	27/60 (45%)
SREBP	NP_001262064.1	OmpH	<289..>364	CDD:281871	32/98 (33%)
mitfb	NP_571922.2	MITF_TFEB_C_3_N	53..185	CDD:292573	35/147 (24%)
		HLH	293..353	CDD:238036	26/59 (44%)
		DUF3847	347..>380	CDD:289710	8/33 (24%)
		DUF3371	381..496	CDD:288684	24/105 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940