Protein Alignment SREBP and srebf2

DIOPT Version :9

• Sequence 1: NP_001262064.1
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: XP_012816036.1
• Gene: srebf2 / 100144677
• XenbaseID: XB-GENE-1011360
• Length: 1096
• Species: Xenopus tropicalis
• Alignment Length: 1177
• Identity: 346/1177 - (29%)
• Similarity: 541/1177 - (45%)
• Gaps: 186/1177 - (15%)

  Fly     5 LMNLIDAPLDESMDLFKAEDVFEPFDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHTQQTQS 69
            ::..:...:.:..|||: |.:.:.:..:          |.|:.|..:.||....:|  :|..|
 Frog    26 MLQFVSNQVGDFPDLFE-EQLCQSYQGN----------NAMETALPKAYNQAPQQP--YTTST-- 75

  Fly    70 VDQQPQSVEQQPHVKSEHSSPVHIKEELHQQQQQSPLLVYKPDPLIATSYNCPQQQPTGLL---- 130
              .|||::            ||....:: ..|:.:|||  :|.|:|.:|.....||.|.:|
 Frog    76 --PQPQTL------------PVKAPSQV-TPQRTAPLL--QPRPVIQSSPQPQLQQQTVMLTPNF 123

  Fly   131 KAAQPTATIHH-MDAQRMPPNTAVYPPSLGSSFVYQSMSPPTSP------------VESANQNVN 182
            ..|..|..|.. :..|....:..|..|.:.|....|.|.|.|..            .::||..:.
 Frog   124 STAPQTRIIQQPLIYQNAATSFQVLQPPVQSLMTTQQMQPVTIQQQVQTVQAQRVLTQAANGTIQ 188

  Fly   183 VMQPVAATPAPASAPLPQQSYP---QPFITYNSKAGMTSDEAMYFLLQPTVASP------TPSPP 238
            .:.|  ||......|..|| .|   ||.|.......:|:.:|....:..|:.:|      ||...
 Frog   189 TLTP--ATTVQTVTPQVQQ-VPVLVQPQIIKTESLVLTAVKADGSPVMTTMQNPAITTLATPIQT 250

  Fly   239 VA-PPPTSTGSRASKVRVAPLAPSPAAMEVQGKVPINRV-----QPKV-KE-VKRSAHNAIERRY 295
            .| ..||..||..:.:...|:      |..|.|:||.:|     ||:| || .:|:.||.||:||
 Frog   251 TALQVPTLMGSNGTILTTMPV------MMGQEKMPIKQVPGSLKQPEVPKEGERRTTHNIIEKRY 309

  Fly   296 RTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMARDGSKVK 360
            |:||||||.|||:||:|..||::||.||:|:||.|:.||:.|       |:|::|.||
 Frog   310 RSSINDKIIELKDLVMGTDAKMHKSGVLKKAIDYIKYLQQVN-------QKLRQENMA------- 360

  Fly   361 DLLQLGTRPGRASK--------------KRRESSQTFTTDAGLTPPRSDESDPSLSPMHSDISLP 411
              |:|..:..:..|              |..|.:|....   ::||.||...|::...:|..|.|
 Frog   361 --LKLANQKNKYLKGIDLSSLVDTSIGMKMDEFNQNILM---MSPPASDSGSPAVFSPYSVDSEP 420

  Fly   412 PSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFMFAILAVNPFKTFL--QRGHYD 474
            .||.        .......:|| ..|:.: ||...||:.||...|..|:.||..:.|  :.|.|.
 Frog   421 GSPL--------LDDEKVKDEP-DSPTGL-GMMDRSRMLLCTMTFLCLSFNPLTSLLHSESGQYT 475

  Fly   475 SNDDLGDMSGQRRILSYDVEGEGFAVWQQSSW---------IWLLNFTLMLGCLVKLLVYGDP-- 528
            .....|  :|:..:   .:|..||    ..||         :||:|..::|...:|||::|:|
 Frog   476 ERVQHG--TGRTML---GIETSGF----YGSWFDWLIPTLILWLVNGVIVLSVFMKLLIHGEPVT 531

  Fly   529 QLDAQTDA-YCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYLQTTWQFLRFLFH 592
            :|.:::.. :.:||::||...::|....|......||.:.|.||||||.:.....:|..:|....
 Frog   532 RLHSRSSVKFWRHRKQADLDLAKGDFGAAAINLQTCLCVLGRSLPASRFDLACSLSWNIIRCSLQ 596

  Fly   593 RLWLGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTGN-GSRGDMNGIMMALFASN 656
            ::.|.|.|.:.|.|....|..:.:|..|||:.||::::|:||.|||. .|..:.:|:.:||.|.|
 Frog   597 KISLVRWLLKHSPGYCKKAEFQDEATTSARDAALVYHKLHQLHLTGKLPSNWNCSGLNLALCAVN 661

  Fly   657 MAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQECGLTRATEQT--QELRW 719
            :||.|.|.::|.....||:.||::||.|.|...:.|.| |::.     |....::|::  ..:||
 Frog   662 LAECAGNKISPNLLAEIHLTTAIQMKTSFPSRFRFLTA-YFLG-----CAQNASSEESLPDPVRW 720

  Fly   720 AFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLLFKAIQCLVGAGHKS 784
            .....|..:.....:..   .|..:|..:|..|||.||...:.:.:.|.||.||:..:  |..::
 Frog   721 LAHPLGKYFFINSNWAL---KSVTKDSLYTSTRNPADPVTQIHRAFCESLLEKAMYTM--AKPET 780

  Fly   785 GGLPTSSVSGEAEQLQQ--------QQHSGTIVSNVLKYTSLLKDTLWADEDERDTNVVWWADVL 841
            ...|....|.|..:.|:        ....|.|.|..|..:|.:...        |....||..|.
 Frog   781 SKAPPEEESCEFSRAQEYLKLLSGFADSVGNIASLPLSGSSPMSSA--------DPICRWWYSVS 837

  Fly   842 ETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPKALHAVLRAKMILLKNNGNALDKSLKQ 906
            ..|:.||.|:|::.:..:..::::|..|.   .::.|.||:..:.||....:....:....|...
 Frog   838 SMAIGWLQGDDSVVKSHFAEVERIPKLLD---SDNPLVKAVIHMCRAMQAAVLGKCDGPQSSFYH 899

  Fly   907 LVNILCDESSVELQECLTVNRITDAKGIKLLFQLLTCDWLLETRTALWELEHMNMEDDG-FYQVP 970
                 |:::|..|...|.::.......:..:.|||.||.||..||:||:.:..:....| ....|
 Frog   900 -----CEKASTFLWNSLNMSSTGSYANLNKVVQLLICDLLLSLRTSLWQKQSSSSPAAGESIHAP 959

  Fly   971 GEVLEKFQTDLNSLRNIVENIPNAQSRIYLYEAVCRLMAGASPCPTQQLLDRSLRSRNAHSSIFC 1035
            ..||..||.||:|||.:......|..:::|:||..||||||||..|.|||..||:.|.|.::
 Frog   960 TSVLTGFQRDLSSLRRLALTFKPAHCKLFLHEATVRLMAGASPTRTHQLLQHSLQKRTALAN--- 1021

  Fly  1036 GSKDRRQQNFVGGERERASAMYVACKYLPPALLSSPGERAGMLAEAAKTLEKVGDKRKLKECYQL 1100
               .:...:.:.|:||||:|:.:||::||.:.|||||:||.||||||:|||||||:|...:|.|:
 Frog  1022 ---KQGDLDSLPGQRERATAILLACRHLPLSFLSSPGQRAVMLAEAARTLEKVGDRRSYHDCQQM 1083

  Fly  1101 MKSLGNG 1107
            |..|..|
 Frog  1084 MVKLSGG 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	34/57 (60%)
		OmpH	<289..>364	CDD:281871	36/74 (49%)
srebf2	XP_012816036.1	bHLHzip_SREBP2	293..369	CDD:381492	42/91 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	350	1.000	Domainoid score	I1018
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1693
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167699at33208
OrthoFinder	1	1.000	-	-		FOG0001476
OrthoInspector	1	1.000	-	-		otm48521
Panther	1	1.100	-	-	LDO	PTHR46062
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X2374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190