DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SREBP and srebf2

DIOPT Version :9

Sequence 1:	NP_001262064.1	Gene:	SREBP / 40155	FlyBaseID:	FBgn0261283	Length:	1113	Species:	Drosophila melanogaster
Sequence 2:	NP_001082935.1	Gene:	srebf2 / 100037309	ZFINID:	ZDB-GENE-070410-8	Length:	1099	Species:	Danio rerio

Alignment Length:	1210	Identity:	345/1210 - (28%)
Similarity:	523/1210 - (43%)	Gaps:	220/1210 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTT-LMNLIDAPLDESMDLFKAEDVFEPFDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHT 64
            ||.: .|:.:|..|.|..|.|...|:         .:||..:.|.:|.  ..::...:....|..
Zfish     1 MDASEFMDTMDPSLSELGDEFTLGDI---------DEMLQFVSNQVDF--PDIFEDQMGGGATAR 54

  Fly    65 QQTQSVDQQPQSVEQQPHVKSEHSSPVHIK----------EELHQQQQQSPLLVYKPDPLIATSY 119
            ...|:|   |.::...||...:.||..|.:          .:.|.|.:..|:|..:|.|:.....
Zfish    55 TLPQAV---PSAILTPPHTPVQTSSQTHTQTLTQAHTQTHTQTHTQTRTPPVLQPRPQPITQVQT 116

  Fly   120 NCPQQQPTGLLKAAQ-------PTATIHHMDAQRMPPNTAVYPPSLGSSF-----VYQSM--SPP 170
            .....|...:...||       ||||     ..|...|..:...:..:||     ..||:  ||.
Zfish   117 QTFPMQTLAVQTQAQPQTVMITPTAT-----PSRFIQNQVICQQNNATSFQVLQPQMQSIMTSPQ 176

  Fly   171 TSPVESANQNVNVMQPVAAT-----PAPASAPLPQQSYP----QPFITYNSKAGMTSDEAMYFLL 226
            ..|:...:|  .|:.|...|     .||.:.....|..|    ||.|.......:|:......:|
Zfish   177 VQPMTIQHQ--RVLTPAGQTIQTLSTAPTTVHTMSQQVPVLVHQPQILKTDSLLLTTKPDGTQVL 239

  Fly   227 QPTVASPTPSPPVAPP--------PTSTGSR-----------ASKVRVAPLAPSPAAMEVQGKVP 272
            . ||.|||....:..|        ||...|.           ..|:.:..|:..||......:|.
Zfish   240 S-TVQSPTGITTLTTPIQTTALQMPTLMSSNILTTVPVVMGGGDKLPIKQLSSGPAHNIGGARVG 303

  Fly   273 INR---VQP--KVKE-VKRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIR 331
            :.:   |.|  .||| .:|:.||.||:|||:||||||.||::||:|..||::||.||||:||.|:
Zfish   304 VEQSPVVGPGGVVKEGERRTTHNIIEKRYRSSINDKILELRDLVLGNDAKMHKSGVLRKAIDYIK 368

  Fly   332 DLQRQNHDLKAELQRLQRELMARDGSKVKDL-LQLGTRPGRASKKRRESSQTFTTDAGLTPPRSD 395
            .||:.||.|:.|...|:........:.|.|: |:|          :.|.|.       ::||.||
Zfish   369 YLQQVNHKLRQENLTLKMANQKNKSACVSDVDLEL----------KAEVSL-------ISPPPSD 416

  Fly   396 ESDPS---LSPMHSDISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSMR--GMATHSRLGLCMFM 455
            ....|   |||...| |.|.||.            ..:|:....|.|..  |:...|||.||...
Zfish   417 SGSSSPAQLSPYCID-SEPGSPL------------LEHEQLKSEPDSPSCVGVMDRSRLLLCALS 468

  Fly   456 FAILAVNPFKTFLQRGHYDSNDDLGDMSGQRRILSYDVEGEGFAVWQQSSW-------IWLLN-F 512
            |..|::||..:.|.......:.::......|.:.|...:.:.|..|   .|       :|::: .
Zfish   469 FLCLSLNPLPSLLGAEAPAGSPEVAGHGPTRTLFSLPAQTQSFGAW---LWCVLPFLLVWVVSGV 530

  Fly   513 TLMLGCLVKLLVYGDP--QLDAQTDA-YCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPAS 574
            .::.|| |::|...:|  .|.:.|.. :.:||::||....:|..:.|......||.:....||.:
Zfish   531 GVVWGC-VRVLYLWEPVTPLHSPTSVRFWRHRKQADLQLYRGDYAGAVLSLQTCLSVLSRVLPVT 594

  Fly   575 RLECYLQTTWQFLRFLFHRL----WLGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQ 635
            .|:.....:|..:|:...|.    ||.|::..|..|        :::..|:|:.||::::|:|||
Zfish   595 TLDIMCSLSWNLIRYCLRRPAPLGWLVRLVGGRHEG--------EESQTSSRDAALVYHKLSQLQ 651

  Fly   636 LTGNGSRGDMNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSR 700
            |||...|..:.|:.::|.|.|:.|.|...||..:.:.::|..|:.::.:..|.|..|.| |.:|.
Zfish   652 LTGQMERRPLWGVCVSLSAVNLCESAEGKLTATQQVQVYVTAAISVRAALGKHLTCLPA-YLLSC 715

  Fly   701 ARQECGLTRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDG-FFTRLRNPCDPAAHVIKQ 764
            |......:.:......|||.||..|.::    ..:.|.|...|.|| .||..|:..||.|.:.:.
Zfish   716 AEALTCQSDSKPLPDCLRWIFTPLGRQF----FLSCDWSVRSESDGQIFTSARDKADPIAQLHRC 776

  Fly   765 YREHLLFKAIQCLVGAGHKSGGLPTSSVSGEAEQLQQQQHSGTIVSNVLKYTSLLKDTLWADEDE 829
            :.:.||.:|...|:                   :.|.::.:|.. :.||::..||..   ..||.
Zfish   777 FCQKLLERATHTLI-------------------EPQSREDAGEF-TGVLEFLQLLNS---CTEDS 818

  Fly   830 ------------------RDTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGEND 876
                              ||....|||.||..|||||.|:|.....|....::||..|...   |
Zfish   819 APSTAPFPALANQSSTSVRDPVCRWWASVLTAAVHWLQGDDASVRSLLAEAERMPRALHTL---D 880

  Fly   877 H-LPKALHAVLRA-KMILLKNNGNALDKSLKQLVNILCDESSVEL--QECLTVNRITDAKGIKLL 937
            | ||||:.|:.:| :|.:....|..:...|..     |..:|.:|  ..|.:.|.....||:
Zfish   881 HPLPKAVLALCKAVQMSVCPQKGEGVVSCLSH-----CQRASAQLHISVCQSHNNTWLHKGV--- 937

  Fly   938 FQLLTCDWLLETRTALWELEHMNMEDDGFYQVPGEVLEKFQTDLNSLRNIVENIPNAQSRIYLYE 1002
             :||.||.||..||:||:....:..:.|  ..||..|..||.||:|||.:.:....||.:::|:|
Zfish   938 -ELLVCDLLLTLRTSLWQRGGGSNGEPG--PAPGSQLSGFQRDLSSLRRLGQAHRQAQHKLFLHE 999

  Fly  1003 AVCRLMAGASPCPTQQLLDRSLRSRNAHSSIFCGSKDRRQQNFVGGERERASAMYVACKYLPPAL 1067
            ...||||||||..|.||    ||.|..:.:...|       ..|.||||||.|:.:||::||..|
Zfish  1000 TTVRLMAGASPTRTHQL----LRHRTHNYTTTDG-------ECVLGERERAHAILLACRHLPLPL 1053

  Fly  1068 LSSPGERAGMLAEAAKTLEKVGDKRKLKECYQLMKSLGNG 1107
            |:.||.||.:||||.:|||:|||:|.|::|..::..|..|
Zfish  1054 LTPPGHRARLLAEAKRTLERVGDRRSLQDCQHILLRLSGG 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	34/57 (60%)
SREBP	NP_001262064.1	OmpH	<289..>364	CDD:281871	37/75 (49%)
srebf2	NP_001082935.1	Transcriptional activation (acidic). /evidence=ECO:0000250\|UniProtKB:P36956	1..47		13/56 (23%)
		TFIIA	57..>221	CDD:281188	40/173 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..107		9/41 (22%)
		HLH	321..371	CDD:278439	30/49 (61%)
		Leucine-zipper	370..391		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2027
eggNOG	1	0.900	-	-		E1_KOG2588
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2483
OMA	1	1.010	-	-		QHG52391
OrthoDB	1	1.010	-	-		D167699at33208
OrthoFinder	1	1.000	-	-		FOG0001476
OrthoInspector	1	1.000	-	-		otm25465
orthoMCL	1	0.900	-	-		OOG6_104643
Panther	1	1.100	-	-	LDO	PTHR46062
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X2374
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870