Protein Alignment SREBP and srebf2

DIOPT Version :10

• Sequence 1: NP_524166.2
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Sequence 2: NP_001082935.2
• Gene: srebf2 / 100037309
• ZFINID: ZDB-GENE-070410-8
• Length: 1095
• Species: Danio rerio
• Alignment Length: 1204
• Identity: 346/1204 - (28%)
• Similarity: 522/1204 - (43%)
• Gaps: 212/1204 - (17%)

  Fly     1 MDTT-LMNLIDAPLDESMDLFKAEDVFEPFDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHT 64
            ||.: .|..:|..|.|..|.|...|:         .:||..:.|.:|.  ..::...:....|..
Zfish     1 MDASEFMETMDPSLSELGDEFTLGDI---------DEMLQFVSNQVDF--PDIFEDQMGGGATAR 54

  Fly    65 QQTQSVDQQPQSVEQQPHVKSEHSSPVHIK------EELHQQQQQSPLLVYKPDPLIATSYNCPQ 123
            ...|:|   |.::...||...:.||..|.:      .:.|.|.:..|:|..:|.|:.........
Zfish    55 TLPQAV---PSAILTPPHTPVQTSSQTHTQTLTQAHTQTHTQTRTPPVLQPRPQPITQVQTQTFP 116

  Fly   124 QQPTGLLKAAQ-------PTATIHHMDAQRMPPNTAVYPPSLGSSF-----VYQSM--SPPTSPV 174
            .|...:...||       ||||     ..|...|..:...:..:||     ..||:  ||...|:
Zfish   117 MQTLAVQTQAQPQTVMITPTAT-----PSRFIQNQVICQQNNATSFQVLQPQMQSIMTSPQVQPM 176

  Fly   175 ESANQNVNVMQPVAAT-----PAPASAPLPQQSYP----QPFITYNSKAGMTSDEAMYFLLQPTV 230
            ...:|  .|:.|...|     .||.:.....|..|    ||.|.......:|:......:|. ||
Zfish   177 TIQHQ--RVLTPAGQTIQTLSTAPTTVHTMSQQVPVLVHQPQILKTDSLLLTTKPDGTQVLS-TV 238

  Fly   231 ASPTPSPPVAPP--------PTSTGSR-----------ASKVRVAPLAPSPAAMEVQGKVPINR- 275
            .|||....:..|        ||...|.           ..|:.:..|:..||......:|.:.:
Zfish   239 QSPTGITTLTTPIQTTALQMPTLMSSNILTTVPVVMGGGDKLPIKQLSSGPAHNIGGARVGVEQS 303

  Fly   276 --VQP--KVKE-VKRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIRDLQR 335
              |.|  .||| .:|:.||.||:|||:||||||.||::||:|..||::||.||||:||.|:.||:
Zfish   304 PVVGPGGVVKEGERRTTHNIIEKRYRSSINDKILELRDLVLGNDAKMHKSGVLRKAIDYIKYLQQ 368

  Fly   336 QNHDLKAELQRLQRELMARDGSKVKDL-LQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDESDP 399
            .||.|:.|...|:........:.|.|: |:|          :.|.|.       ::||.||....
Zfish   369 VNHKLRQENLTLKMANQKNKSACVSDVDLEL----------KAEVSL-------ISPPPSDSGSS 416

  Fly   400 S---LSPMHSDISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFMFAILAV 461
            |   |||...| |.|.||........|...|         ||.: |:...|||.||...|..|::
Zfish   417 SPAQLSPYCID-SEPGSPLLEHEQLKSEPDS---------PSCV-GVMDRSRLLLCALSFLCLSL 470

  Fly   462 NPFKTFLQRGHYDSNDDLGDMSGQRRILSYDVEGEGFAVWQQSSW-------IWLLN-FTLMLGC 518
            ||..:.|.......:.::......|.:.|...:.:.|..|   .|       :|::: ..::.||
Zfish   471 NPLPSLLGAEAPAGSPEVAGHGPTRTLFSLPAQTQSFGAW---LWCVLPFLLVWVVSGVGVVWGC 532

  Fly   519 LVKLLVYGDP--QLDAQTDA-YCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYL 580
             |::|...:|  .|.:.|.. :.:||::||....:|..:.|......||.:....||.:.|:...
Zfish   533 -VRVLYLWEPVTPLHSPTSVRFWRHRKQADLQLYRGDYAGAVLSLQTCLSVLSRVLPVTTLDIMC 596

  Fly   581 QTTWQFLRFLFHRL----WLGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTGNGS 641
            ..:|..:|:...|.    ||.|::..|..|        :::..|:|:.||::::|:||||||...
Zfish   597 SLSWNLIRYCLRRPAPLGWLVRLVGGRHEG--------EESQTSSRDAALVYHKLSQLQLTGQME 653

  Fly   642 RGDMNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQECG 706
            |..:.|:.::|.|.|:.|.|...||..:.:.::|..|:.::.:..|.|..|.| |.:|.|.....
Zfish   654 RRPLWGVCVSLSAVNLCESAEGKLTAAQQVQVYVTAAISVRAALGKHLTCLPA-YLLSCAEALTC 717

  Fly   707 LTRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDG-FFTRLRNPCDPAAHVIKQYREHLL 770
            .:.:......|||.||..|.::    ..:.|.|...|.|| .||..|:..||.|.:.:.:.:.||
Zfish   718 QSDSKPLPDCLRWIFTPLGRQF----FLSCDWSVRSESDGQIFTSARDKVDPIAQLHRCFCQKLL 778

  Fly   771 FKAIQCLVGAGHKSGGLPTSSVSGEAEQLQQQQHSGTIVSNVLKYTSLLKDTLWADEDE------ 829
            .:|...|:                   :.|.::.:|.. :.||::..||..   ..||.
Zfish   779 ERATHTLI-------------------EPQSREDAGEF-TGVLEFLQLLNS---CTEDSAPSTAP 820

  Fly   830 ------------RDTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDH-LPKA 881
                        ||....|||.||..|||||.|:|.....|....::||..|...   || ||||
Zfish   821 FPALANQSSTSVRDPVCRWWASVLTAAVHWLQGDDASVRSLLAEAERMPRALHTL---DHPLPKA 882

  Fly   882 LHAVLRA-KMILLKNNGNALDKSLKQLVNILCDESSVEL--QECLTVNRITDAKGIKLLFQLLTC 943
            :.|:.:| :|.:....|..:...|..     |..:|.:|  ..|.:.|.....||:    :||.|
Zfish   883 VLALCKAVQMSVCPQKGEGVVSCLSH-----CQRASAQLHISVCQSHNNTWLHKGV----ELLVC 938

  Fly   944 DWLLETRTALWELEHMNMEDDGFYQVPGEVLEKFQTDLNSLRNIVENIPNAQSRIYLYEAVCRLM 1008
            |.||..||:||:....:..:.|  ..||..|..||.||:|||.:.:....||.:::|:|...|||
Zfish   939 DLLLTLRTSLWQRGGGSNGEPG--PAPGSQLSGFQRDLSSLRRLGQAHRQAQHKLFLHETTVRLM 1001

  Fly  1009 AGASPCPTQQLLDRSLRSRNAHSSIFCGSKDRRQQNFVGGERERASAMYVACKYLPPALLSSPGE 1073
            |||||..|.||    ||.|..:.:...|       ..|.||||||.|:.:||::||..||:.||.
Zfish  1002 AGASPTRTHQL----LRHRTHNYTTTDG-------ECVLGERERAHAILLACRHLPLPLLTPPGH 1055

  Fly  1074 RAGMLAEAAKTLEKVGDKRKLKECYQLMKSLGNG 1107
            ||.:||||.:|||:|||:|.|::|..::..|..|
Zfish  1056 RARLLAEAKRTLERVGDRRSLQDCQHILLRLSGG 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SREBP	NP_524166.2	PAT1	<55..>229	CDD:401645	44/202 (22%)
		bHLHzip_SREBP	279..351	CDD:381400	40/72 (56%)
srebf2	NP_001082935.2	Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956, ECO:0000250|UniProtKB:Q12772	1..47		13/56 (23%)
		Leucine-zipper	366..387		7/20 (35%)