DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42637 and Phlpp1

DIOPT Version :9

Sequence 1:NP_001007096.1 Gene:CG42637 / 40153 FlyBaseID:FBgn0261360 Length:1525 Species:Drosophila melanogaster
Sequence 2:NP_598582.3 Gene:Phlpp1 / 98432 MGIID:2138327 Length:1687 Species:Mus musculus


Alignment Length:1114 Identity:196/1114 - (17%)
Similarity:351/1114 - (31%) Gaps:410/1114 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   540 GNEIVSSPSKVSLMSAQSYGSRWTNQF---------VTSTGRL--RGAVVRIKELKFPRKRDISR 593
            ||.:.|.|:::..|...||.....|:|         :|:..:|  .|..|....|:..|:....:
Mouse   702 GNFLQSLPAELESMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCVETLRLQALRRMPHIK 766

  Fly   594 EIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDL 658
            .:...:.:||:|..|.:                 |:....:..|:.:|   ||.||  .::|.:.
Mouse   767 HVDLRLNILRKLMADEV-----------------DFVQHVTQLDLRDN---KLGDL--DAMIFNN 809

  Fly   659 IKGMIYIHNSQLV------------YHGNLK------------------SSNCVVT-SRWM---- 688
            |: :::...:|||            |..:.:                  |.||:.: ..|:    
Mouse   810 IE-VLHCERNQLVTLNVCGYFLKALYASSNELAQLDVYPVPNYLSYMDVSRNCLESVPEWVCESR 873

  Fly   689 -LQVTDFGLHELRQ------CAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYE 746
             |:|.|.|.:::.:      |  |.|:.:.....|:|.|.||.|..               ...|
Mouse   874 KLEVLDIGHNQICELPARLFC--NSSLRKLLAGHNRLARLPERLER---------------TSVE 921

  Fly   747 IFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLA------------- 798
            :         ::.:..:|.:....|.:|. |..|....|..:.|:.|...|:             
Mouse   922 V---------LDVQHNQITELPPNLLMKA-DSLRFLNASANKLETLPPATLSEETSSILQELYLT 976

  Fly   799 --CIRDCWAEDPEERPEFSVIR---NRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLL 858
              |:.|.........|...::.   |||:.....|...:  :.:|.::...|.|:.|.|  |.:.
Mouse   977 NNCLTDKCVPLLTGHPRLKILHMAYNRLQSFPASKMAKL--EELEEIDISGNKLKAIPT--TIMN 1037

  Fly   859 CEEKMKTEDLLH----------RMLPQ--------SVAEKLTMGQGVEPVSYDLVTIYFSDIVGF 905
            | .:|.|. :.|          ..||:        :...::|:.:.:.|...:|      |:.|.
Mouse  1038 C-RRMHTV-IAHSNCIEVFPEVMQLPEVKCVDLSCNELSEITLPENLPPKLQEL------DLTGN 1094

  Fly   906 TAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVE--TIGDAYMVVSGLPI--KNGDRHAGEIA 966
            ..::.:...|:::|.:.              .:|::  :.|||    ||.|.  .:|...|..:.
Mouse  1095 PRLALDHKSLELLNNIR--------------CFKIDQPSAGDA----SGAPAVWSHGYTEASGVK 1141

  Fly   967 SMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGD-------------- 1017
            :.......:|...|      :..:...|:..|.....|..|..   |...|              
Mouse  1142 NKLCVAALSVNNFR------DNREALYGVFDGDRNVEVPYLLQ---CTMSDILAEELQKTKNEEE 1197

  Fly  1018 -TVNTASRMES---------NGEALKIHIS-----------------NKCKLALDK------LGG 1049
             .|||...|:.         .|.|:..||.                 .||:..|.:      |..
Mouse  1198 YMVNTFIVMQRKLGTAGQKLGGAAVLCHIKPDPVDLGGSFTLTSANVGKCQTVLCRNGKPLSLSR 1262

  Fly  1050 GY----------ITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPR-KSPK 1103
            .|          |.:.:.::...||       :.|..|:.   :::....:.|.:..||. :|..
Mouse  1263 SYIMSCEEERKRIKQHKAIITEDGK-------VNGVTEST---RILGYTFLHPSVVPRPHVQSVL 1317

  Fly  1104 LNPD---------------SRQPSIQAMHFCGTGSRRQSTVPRAM----------------DGES 1137
            |.|.               |...:::|:.          .||.|:                |..|
Mouse  1318 LTPQDEFFILGSKGLWDSLSIDEAVEAVR----------NVPDALAAAKKLCTLAQSYGCHDSIS 1372

  Fly  1138 TYSLQGSVRES---------------------PRMVSKRDRDRERPPINGLGAGHFVGGALLE-S 1180
            ...:|.||.|.                     |..|:...:||   |.:|||......|...| |
Mouse  1373 AVVVQLSVTEDSFCCCELSAGGSMPPPSPGIFPPSVNMVIKDR---PSDGLGVPSSSSGMASEIS 1434

  Fly  1181 AQASLSTLNHSETNETNCDMDGGSGGVSGSGSGLVRQPNALHKPLAMVR--PHRIISAAQLPQLG 1243
            ::.|.|.:: ||...|..| :..||.::.|......:...:..|:.:..  ..::.||.......
Mouse  1435 SELSTSEMS-SEVGSTASD-EPPSGVLNESSPAYPNEQRCMLHPVCLSNSFQRQLSSATFSSAFS 1497

  Fly  1244 DNDDDSADTLLRESRSLDPMPMQQLRKRHDRVKLPPSKLSKNNSRSLDTGVSLISGNPNGEVHSS 1308
            ||..||.|                        :.|...:..|.|| ::..|         ::|.|
Mouse  1498 DNGLDSDD------------------------EEPIEGVFSNGSR-VEVEV---------DIHCS 1528

  Fly  1309 ---QLDLDNEMTANPVDATD------GYDDELGLLMRHDNGQLPALRYSGSFPNAQISIVPTGRS 1364
               :.:....:...|.:|:|      ..:||.||..:.|                        .|
Mouse  1529 RAKEKERQQHLLQVPAEASDEGIVISANEDESGLSKKAD------------------------FS 1569

  Fly  1365 AGGGGGGREGGGSNCAKHLNNNCNGGVNVEDDLESPLLQRQASLS------------VPPE---- 1413
            |.|..|.|...||...:..::|.     :|...::||.:.....:            :|||    
Mouse  1570 AVGTIGRRRANGSVAPQERSHNV-----IEVAADAPLRKPGGYFAAPAQPDPDDQFIIPPELEEE 1629

  Fly  1414 --EMLAHNK 1420
              |::.|::
Mouse  1630 VKEIMKHHQ 1638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42637NP_001007096.1 PBP1_Speract_GC_like 26..445 CDD:107365
ANF_receptor 48..412 CDD:279440
PK_GC-A_B 543..827 CDD:270944 63/354 (18%)
HNOBA <835..881 CDD:285003 12/63 (19%)
CYCc 860..1052 CDD:214485 42/270 (16%)
Guanylate_cyc 887..1074 CDD:278633 39/247 (16%)
Phlpp1NP_598582.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..406
PH_PHLPP-like 491..587 CDD:270131
PH 511..592 CDD:278594
LRR_RI 581..885 CDD:238064 40/205 (20%)
LRR_8 594..659 CDD:290566
LRR 1 594..615
leucine-rich repeat 597..617 CDD:275380
LRR 2 617..638
leucine-rich repeat 618..648 CDD:275380
LRR_8 647..726 CDD:290566 7/23 (30%)
LRR 3 648..669
LRR 4 671..692
leucine-rich repeat 672..694 CDD:275380
LRR 5 694..715 4/12 (33%)
leucine-rich repeat 695..717 CDD:275380 5/14 (36%)
LRR 6 717..739 4/21 (19%)
leucine-rich repeat 718..740 CDD:275380 4/21 (19%)
LRR 7 740..760 4/19 (21%)
leucine-rich repeat 741..764 CDD:275380 5/22 (23%)
LRR 8 764..785 4/37 (11%)
LRR_RI 768..1030 CDD:238064 54/313 (17%)
leucine-rich repeat 768..788 CDD:275380 5/36 (14%)
LRR 9 788..809 7/25 (28%)
leucine-rich repeat 789..809 CDD:275380 7/24 (29%)
leucine-rich repeat 810..851 CDD:275380 5/41 (12%)
LRR 10 829..850 1/20 (5%)
LRR 11 851..872 4/20 (20%)
leucine-rich repeat 852..874 CDD:275380 4/21 (19%)
LRR 12 874..895 5/22 (23%)
leucine-rich repeat 875..897 CDD:275380 6/23 (26%)
LRR_8 896..954 CDD:290566 14/82 (17%)
LRR 13 897..918 7/35 (20%)
leucine-rich repeat 898..919 CDD:275380 6/35 (17%)
LRR 14 919..940 3/29 (10%)
leucine-rich repeat 920..943 CDD:275380 4/32 (13%)
LRR 15 943..964 5/20 (25%)
leucine-rich repeat 944..967 CDD:275380 5/22 (23%)
LRR 16 969..989 2/19 (11%)
LRR_8 970..1028 CDD:290566 9/59 (15%)
leucine-rich repeat 970..993 CDD:275380 2/22 (9%)
LRR 17 993..1014 4/20 (20%)
leucine-rich repeat 994..1017 CDD:275380 4/24 (17%)
LRR 18 1017..1038 6/22 (27%)
LRR 19 1040..1061 3/21 (14%)
LRR 20 1062..1083 1/20 (5%)
leucine-rich repeat 1063..1085 CDD:275380 1/21 (5%)
LRR 21 1085..1106 4/26 (15%)
PP2Cc 1124..1376 CDD:214625 44/280 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1414..1465 18/55 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1604..1687 5/35 (14%)
PDZ-binding 1685..1687
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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