DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1210	Identity:	367/1210 - (30%)
Similarity:	551/1210 - (45%)	Gaps:	209/1210 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RWPFNLL--LLLSVAVRDCSNHRTVLTVGYLTALTGD---LKTRQGLAISGALTMALDEVNKD-- 60
            |||...|  |||.:.:...|....|..||.|.....|   .:.|..|    |..:|.|.:|:|
  Rat    32 RWPGPGLPGLLLLLLLPSPSAFSAVFKVGVLGPWACDPIFARARPDL----AARLATDRLNRDLA 92

  Fly    61 --------PNLLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGP--CYVEAIVSQSR 115
                    ..|||...|      |.|.....:.|:|.     ::.:.||..|  |....:::|..
  Rat    93 LDGGPWFEVTLLPEPCL------TPGSLGAVSSALTR-----VSGLVGPVNPAACRPAELLAQEA 146

  Fly   116 NIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY--EDVWSPVADLLKD 178
            .:.::.:.|...||:     ..|.|..|....:|..||:.:.|.:.:::.  :|:|......|..
  Rat   147 GVALVPWGCPGTRAA-----GTTAPAVTPAADALYVLLKAFRWARVALITAPQDLWVEAGRALST 206

  Fly   179 QATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSM 243
            ....|.:.:....|.:.:.:....:.|...|.|...::|...|:.    |.||...... .:.:.
  Rat   207 ALRARGLPVALVTSMVPSDLSGAREALRRIRDGPRVRVVIMVMHS----VLLGGEEQRY-LLEAA 266

  Fly   244 ETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTK 308
            |..|| ..|..:.:..|.:.|:.....:.|......:.:...|..        .|.:....||..
  Rat   267 EELGL-TDGSLVFLPFDTLHYALSPGPEALAAFVNSSKLRRAHDA--------VLTLTRRCPPGG 322

  Fly   309 DYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLT 373
            ......::.|:: .:.|.:|::          |.:|.....:||:|.|.|..|       ||.
  Rat   323 SVQDSLRRAQEH-QELPLDLDL----------KQVSPLFGTIYDAVFLLAGGV-------TRA-- 367

  Fly   374 DDVIFEVASNGTRVIDTIIKNRT-------YMSITG-----SKIKIDQYGDSEGNFSVLAYKPHK 426
                 ..|..|..|....:..:.       :..|.|     |.:.:|.....|..|:.
  Rat   368 -----RAAVGGGWVSGASVARQMREAQVFGFCGILGRTEEPSFVLLDTDAAGERLFTT------- 420

  Fly   427 WNNSNNMPCNYHMV-PVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGF-ANELCK---KD 486
                       |:: ||....:....|        :.:|.|...|..:|.|.| .:.:|.   :.
  Rat   421 -----------HLLDPVLGSLRSAGTP--------VHFPRGAPAPGPDPSCWFDPDVICNGGVEP 466

  Fly   487 DTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELE-IEGLLWKIDPNEI------------KGY 538
            ...:...:..:|:|:    :|.......|...:.:: :.|      ||:|            :|
  Rat   467 GLVFVGFLLVIVVGL----TGAFLAHYLRHRLLHMQMVSG------PNKIILTLEDVTFLHPQG- 520

  Fly   539 SGNEIVSSPSKVSLMSAQSYGSRWTN---------QFVTSTGRLRGAVVRIKELKFPRKRDISRE 594
                  .|..||:..|..|..:|.|:         |..|:.|...|..|.:|  |||.:..::..
  Rat   521 ------GSSRKVAQGSRSSLATRSTSDIRSVPSQPQESTNIGLYEGDWVWLK--KFPGEHHMAIR 577

  Fly   595 IMKEMRL--LRELRHDNINSFIGASVEPTR----------ILLVTDYCAKGSLYDIIENEDIKLD 647
            ...:|..  ||||||:|:..::|..:..|.          :.:|:::||:|||:|::...|||||
  Rat   578 PATKMAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQRDIKLD 642

  Fly   648 DLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQ 712
            .:|.:||:.||||||.|:|: :.|.||.|||.||||..|::|:|||.|...|.:.  ...:.|..
  Rat   643 WMFKSSLLLDLIKGMRYLHH-RGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEA--QRVLPEPP 704

  Fly   713 HYRNQLWRAPELLRN---HIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLK 774
            ...:|||.||||||:   ...|:..|||::..|||.|:..|..|:..:...|:|::..|:..|
  Rat   705 SAEDQLWTAPELLRDPALERRGTLAGDVFSLGIIMQEVVCRSTPYAMLELTPEEVIQRVRSPP-- 767

  Fly   775 GEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEM 839
                  |....::..:..|...:..:..||||.||.||...:..:..|.:..|:..||:|.|:.|
  Rat   768 ------PLCRPLVSMDQAPMECIQLMAQCWAEHPELRPSMDLTFDLFKGINKGRKTNIIDSMLRM 826

  Fly   840 MEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVG 904
            :|:|::||||::.|||..|.:||.||:.||.:|||.||||.|.||..|||..::.||:|||||||
  Rat   827 LEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVG 891

  Fly   905 FTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMA 969
            ||.:||.|.|::||:.||||||:||.||..:||||||||||||||.||||.:||.|||.|||:|:
  Rat   892 FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMS 956

  Fly   970 LELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKI 1034
            |::|.||...|:.|.|...:::|||:|:||.|||||||||||||||||||||||||||.|...:|
  Rat   957 LDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRI 1021

  Fly  1035 HISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRP- 1098
            |::......|..|..|:..|.||...:||||...|:||.|...                 |::|
  Rat  1022 HVNMSTVRILRALDQGFQMECRGRTELKGKGVEDTYWLVGRVG-----------------FNKPI 1069

  Fly  1099 RKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGEST 1138
            .|.|.|.|.:....|.....   ...|:..:.:|..|:.|
  Rat  1070 PKPPDLQPGASNHGISLQEI---PPERRKKLEKARPGQFT 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	83/448 (19%)
		ANF_receptor	48..412	CDD:279440	72/389 (19%)
		PK_GC-A_B	543..827	CDD:270944	101/307 (33%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	119/191 (62%)
		Guanylate_cyc	887..1074	CDD:278633	113/186 (61%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594	83/452 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552		9/38 (24%)
		PK_GC-2D	540..814	CDD:270945	94/286 (33%)
		HNOBA	<823..868	CDD:400168	25/44 (57%)
		CYCc	848..1039	CDD:214485	119/190 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108		9/41 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820