DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	1171	Identity:	380/1171 - (32%)
Similarity:	574/1171 - (49%)	Gaps:	188/1171 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NLLLLLSVAVRDCSNHRTVLTVGYLTA--LTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYL 69
            :|:|:|||.:.........||||:...  ::.....::   :...|...:|::|.:|..|.||
Mouse    27 SLVLMLSVVMLVTCLEAAKLTVGFHAPWNISHPFSVQR---LGAGLQTVVDKLNSEPVGLGNV-- 86

  Fly    70 DLRWNDTKGDTVLATKA-----ITEMICDGIATIFGPEGPCYVEAI--VSQSRNIPMISYK---- 123
              .|..|..::..:.|.     |.::..:.|:.:|||..|...|.|  ::...|||:..:.
Mouse    87 --SWEFTYTNSTCSAKESLAVFIDQVQKEHISALFGPACPEAAEVIGLLASEWNIPLFDFVGQMA 149

  Fly   124 -------CAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL-----------YEDVWS 170
                   |        .|.....||..::...|...|||..|....:.           .:::|.
Mouse   150 ALKDHFWC--------DTCVTLVPPKQEISAVLRESLRYLGWEHIGVFGGSSADSSWEQVDEMWG 206

  Fly   171 PVADLLKDQAT-KRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAAN 234
            .|.|.|:.... ..:|..|...|             |..:.|     ::|.....|:.:.:.::.
Mouse   207 AVEDGLQFHFNITASMRYNSSSS-------------DLLQEG-----LRNMSYVARVIILICSSE 253

  Fly   235 SLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLL 299
            .....:.:....|| ..||::.|.:..:   |....|.:...|::.         .|.::..|:.
Mouse   254 DARRILQAAVDLGL-DTGEFVFILLQQL---EDSFWKEVLTKDKVI---------RFPKVYESVF 305

  Fly   300 VVASTPPTKDY------IQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYA 358
            ::|.:.    |      ..|.|||.:...:|||...|       .....:|.|:|||:|::.|||
Mouse   306 LIAPSA----YGGGIGDDGFRKQVSQELRRPPFQSSI-------TSEDQVSPYSAYLHDALLLYA 359

  Fly   359 WAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNR-TYMSITGSKIKIDQYGDSEGNFSVLAY 422
            ..|::|.:.|          :...:|.::|.|:...: |...||| .:.:|..|....::||.|.
Mouse   360 QTVEEMRKAE----------KDFRDGRQLISTLRAGQVTLQGITG-PVLLDSQGKRHVDYSVYAL 413

  Fly   423 KPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLI-----NGSIDWPSGGEKPADEPMCGFANEL 482
            : ...|.|..:|         :.|.....   |:|     :.:..||. |..|..:|.|||.|:|
Mouse   414 Q-ESGNRSLFLP---------FLHYDSFQ---KVIRPWRNDSNTSWPH-GSLPEYKPGCGFHNDL 464

  Fly   483 CK-KDDT--HYTSTVAAVV----LGVLLFCSGVITMSIYR-KWKIELEIEGLLWKID-------P 532
            || |..|  ..|.||.||:    ..||...:.:..:.::| :.|::.......|:|.       |
Mouse   465 CKTKPPTVAGMTVTVTAVIPTVTFLVLASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSITLLP 529

  Fly   533 NEIKGYSGNEI----VSSPSKVSLMSAQSYGS---RWTNQ--FVTSTGRLRGAVVRI-----KEL 583
            .....:.|..:    ||..|.|.  ::...||   |..::  |....|..:|..|.:     :..
Mouse   530 QHKLSHRGTPVSRRNVSDTSTVK--ASADCGSLVKRHQDEELFFAPVGLYQGNQVALCYIGDEAE 592

  Fly   584 KFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDD 648
            .:.:|..:.||:.    |:.||:|:||..|.|...||..|.:||.||.||||.|::.|.|.::|.
Mouse   593 AWVKKPTVRREVC----LMCELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDW 653

  Fly   649 LFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQH 713
            :|..|..:|::.|::::|.|.|..|||||.|||:|.|...|:::.|||.|.:..:...|..:...
Mouse   654 IFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEAT 718

  Fly   714 YRNQL-WRAPELLR---NHIHGSQKGDVYAFAIIMYEIFSRK--GPFGQINFEPKEIVDYVK--K 770
            ..::| |.||||||   :...|:.:||||:|||::.::..::  |||..:...|:||:..:|  :
Mouse   719 DHSELYWTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQAHGPFEDLEAAPEEIISRIKDPR 783

  Fly   771 LPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQ 835
            .|:    |.||   |::| :.....::|.:|:||.|.||.||.|..|:..|::.......:|:|.
Mouse   784 APV----PLRP---SLLE-DKGDGRIVALVRECWDESPELRPIFPSIKKTLREASPRGHVSILDS 840

  Fly   836 MMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFS 900
            ||..:|.|||:||::|.||||.|..||.|.|.||..|||..|.|:|..|:.|||..::.|||:||
Mouse   841 MMGKLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFS 905

  Fly   901 DIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEI 965
            ||||||.:.:.|:|||||..|||||::||..|:.:||||||||||||||.|||||:||.:||.||
Mouse   906 DIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEI 970

  Fly   966 ASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGE 1030
            |:|||.||......:|.|.|.|.||||||:|||||||||||:|||||||||||||.||||||:..
Mouse   971 ATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSL 1035

  Fly  1031 ALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLF 1095
            .|:||:|.....|| ...|||..:|||.:::||||:..|:||.|.          |...:|.|.|
Mouse  1036 PLRIHVSQSTAGAL-LAAGGYHLQKRGTISVKGKGEQTTFWLKGK----------DGFPVPLPEF 1089

  Fly  1096 S 1096
            :
Mouse  1090 T 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	92/457 (20%)
		ANF_receptor	48..412	CDD:279440	81/400 (20%)
		PK_GC-A_B	543..827	CDD:270944	101/305 (33%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	120/191 (63%)
		Guanylate_cyc	887..1074	CDD:278633	118/186 (63%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595	93/469 (20%)
		PK_GC	555..829	CDD:270894	97/285 (34%)
		CYCc	865..1055	CDD:214485	119/190 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.680