DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001343916.1	Gene:	Gucy1a1 / 60596	MGIID:	1926562	Length:	691	Species:	Mus musculus

Alignment Length:	516	Identity:	145/516 - (28%)
Similarity:	220/516 - (42%)	Gaps:	143/516 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   608 DNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDI---KLDDLFI-----------ASLIHDL 658
            |.:|||       :.:|..:.:|.:......:|:..|   ..|..|:           |.|:..:
Mouse   161 DFLNSF-------STLLKQSSHCQEAERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGI 218

  Fly   659 IKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPE 723
            ||..     ::::|..:::.|......|             ..|.|         :.||    |.
Mouse   219 IKAA-----ARILYESHVEVSLMPPCFR-------------SDCTE---------FVNQ----PY 252

  Fly   724 LLRN-HIHGSQ----KGDVYAFAIIMYEIFSRKGPFGQI---NFEPKEIVDYVKKLPLKGEDPFR 780
            ||.: |:..::    .|...:..:|...:|.:..||..:   :....::.:.:::|..|.:...:
Mouse   253 LLYSVHVKSTKPSLSPGKPQSSLVIPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGK 317

  Fly   781 PEVESIIEAESCPDYVLACIRDCWAEDPEERPEFS----------VIRNRLKKMRGGKTKNIMD- 834
            |..|...|       :|.         |:....||          |||.|.......|:..:||
Mouse   318 PNFEEFFE-------ILT---------PKINQTFSGIMTMLNMQFVIRVRRWDNSVKKSSRVMDL 366

  Fly   835 --QMMEMMEKYA----------------------------NNLEDIVT--ERTR----------- 856
              ||:.::|..|                            |.|.|:|.  |:.|
Mouse   367 KGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGK 431

  Fly   857 ----------LLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAE 911
                      .|.|||.:|.|||..:.|..||::|..||.|:...:..||:.|||||||||:.::
Mouse   432 LKATLEHAHQALEEEKKRTVDLLCSIFPSEVAQQLWQGQIVQAKKFSEVTMLFSDIVGFTAICSQ 496

  Fly   912 STPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAV 976
            .:||||:..||.|||.||:.....||||||||||||.|..||. :..|.||.:||.|||:::...
Mouse   497 CSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-RESDTHAVQIALMALKMMELS 560

  Fly   977 KQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS 1037
            .:....|  .|.:|:|||:|:|.|.|||||:.||||||||:.|..|::.||.....||::|
Mouse   561 NEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	43/250 (17%)
		HNOBA	<835..881	CDD:285003	21/96 (22%)
		CYCc	860..1052	CDD:214485	88/178 (49%)
		Guanylate_cyc	887..1074	CDD:278633	75/151 (50%)
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	41/204 (20%)
Gucy1a1	NP_001343916.1	Guanylate_cyc	472..643	CDD:306677	75/151 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810