DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and gucy2ca

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_009297342.1	Gene:	gucy2ca / 572052	ZFINID:	ZDB-GENE-091118-67	Length:	1025	Species:	Danio rerio

Alignment Length:	1117	Identity:	331/1117 - (29%)
Similarity:	484/1117 - (43%)	Gaps:	274/1117 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 TEMICDGIATIFGPEGPC------YVEAIVSQSRNIPMIS-----YKCAEYRASAIPTFARTEPP 141
            :|:.|    .:.||.  |      .|:..|..:..||:||     ..| :|:..    ..|..||
Zfish   108 SELGC----VMLGPS--CTYATFQLVDQEVGLTLTIPIISAGSFGLSC-DYKQK----LTRLLPP 161

  Fly   142 DTQVVKSLLALLRYYAWNKFSILYEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLD 206
            ..::.:..     ::.|:......:..|.......||..|:                       :
Zfish   162 ARKIAEFF-----FHFWHTSVKNLKPAWKTAYVYKKDNYTE-----------------------E 198

  Fly   207 CCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEK 271
            |    :||      :|.      |.|.::|.....|.|                 |:.||.|...
Zfish   199 C----FWY------INA------LEAPSALFSSNISRE-----------------MLRSESELST 230

  Fly   272 YLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVE 336
            .|:|.|:       ||         :::|:..||   |.|...|:          |..:|...|
Zfish   231 ALKRKDR-------HS---------NIIVMCGTP---DDIYTIKK----------NNTVPSQVV- 265

  Fly   337 SNFSKFISIYAAYLYDSVKLYAWAVDKMLREETR---VLTDDVIFEVASNGTRVIDTIIKNRTYM 398
                 ||.|   .||:.    .:..::......|   |||.......:||      ::.:|.|.:
Zfish   266 -----FILI---DLYNE----GYRTNESSPAHMRNVLVLTMHSFRNYSSN------SVWRNNTTV 312

  Fly   399 SITGSKIKIDQYGDSEGNFSVL----AYKPH---KWNNSNNMPCNYHMVPVAYFHQGEEHPEYKL 456
            || |...|:|..||.:.|.||:    :||..   .::.|.|                    ..|:
Zfish   313 SI-GGYYKLDSSGDRDLNLSVVYTTGSYKYRTLFSFDTSQN--------------------RTKV 356

  Fly   457 INGSIDWP-SGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYR----- 515
            .:.|.|.| ...:.|.|            |........:..:|||:.:..:.||...:||
Zfish   357 KDSSPDLPWDRSQLPRD------------KHTGMEIQEIMMIVLGLSVVLATVIAFILYRQNRRV 409

  Fly   516 -----KWKIELEI-EGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLR 574
                 ||.   .| ..|:..:|..| :.|           :||...:.  .:..|..:...||..
Zfish   410 RFDQKKWS---HISSSLITPLDDKE-RNY-----------ISLTIDED--KKGDNSSLIRKGRYD 457

  Fly   575 GAVVRIKELKFPRKRD--ISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYD 637
            ...|.:|||   |..|  .:.:...|:..|..:.:.|:..|.|.......:..|.::|.:|||..
Zfish   458 KKPVILKEL---RNTDGNFTDDQRIELNALLRIDYYNLTKFYGTVRFDCGVFGVFEFCERGSLRY 519

  Fly   638 IIENE----DIKLDDL-FIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLH 697
            :::::    |....|| |..|:::|:.|||.|:|:|.:..||.|||:||||.:|.::::||||
Zfish   520 VLDDKISYPDASFMDLEFRISVMYDIAKGMSYLHSSNVGVHGRLKSTNCVVDNRMVVKITDFG-- 582

  Fly   698 ELRQCAENESIGEHQHYRNQLWRAPELLRNHIHG-SQKGDVYAFAIIMYEIFSRKGPFGQINFEP 761
                |....|.|:      .||.|||.:|  :.| |||||||:||||..||..||.|     |..
Zfish   583 ----CNTILSPGK------DLWTAPEHMR--VEGISQKGDVYSFAIISQEIILRKSP-----FHT 630

  Fly   762 KEIVDYVKKLPL----KGEDPFRPEV--ESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNR 820
            ....|..:||.|    :|.:.|||::  |.:.|.|:   .:...|:.||.||||:||:|..|...
Zfish   631 SCCSDMAEKLYLVQYPRGPNVFRPDLSFEGVGETEA---ELFVLIKSCWEEDPEKRPDFKRIEGA 692

  Fly   821 LKK----MRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKL 881
            |.|    :......:.||.::..::.|:.|||.:|.|||.|...|:.:.:.|...:||..|...|
Zfish   693 LGKIFSNLHNQANASYMDNLIRRLQMYSRNLEHLVEERTALYKAERDRADQLNFMLLPGPVVRSL 757

  Fly   882 TMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDA 946
            .....|||..||.||||||||||||.:...|||::||:.|||:|..||.|:..:|||||||||||
Zfish   758 KETGRVEPELYDEVTIYFSDIVGFTTICHHSTPMEVVDMLNDIYKNFDSILDHHDVYKVETIGDA 822

  Fly   947 YMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPR 1011
            |||.||||..||:|||.:|..|||::|..:...::.|.|...|.:|||:|:||..|||||..|||
Zfish   823 YMVASGLPRCNGNRHAVDICLMALDILEFMGTFQLRHLPGIPLWIRIGIHSGPCAAGVVGNKMPR 887

  Fly  1012 YCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGAN 1076
            ||||||||||||||||.|..|:||:|......|.:....:..|:||...:||||..:|:||||..
Zfish   888 YCLFGDTVNTASRMESTGLPLRIHVSESTIKILQRTDCEFECERRGETFLKGKGKEMTYWLTGVT 952

  Fly  1077 ENAIQKKLVDMMDMPPPL--FSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTV---------- 1129
            .....      :..||.:  |.|      |..|..:..:..::  ..|:.|:.|:
Zfish   953 GQKYS------LPTPPTVENFQR------LQQDLAERIVSTLN--KRGNERRKTLSTRQRRTHTH 1003

  Fly  1130 --PRAMDGESTY 1139
              ..:.||:..|
Zfish  1004 IHTHSGDGQPEY 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	75/377 (20%)
		ANF_receptor	48..412	CDD:279440	66/337 (20%)
		PK_GC-A_B	543..827	CDD:270944	98/301 (33%)
		HNOBA	<835..881	CDD:285003	14/45 (31%)
		CYCc	860..1052	CDD:214485	102/191 (53%)
		Guanylate_cyc	887..1074	CDD:278633	106/186 (57%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141	78/397 (20%)
		PKc_like	428..698	CDD:304357	101/308 (33%)
		Pkinase_Tyr	451..689	CDD:285015	92/262 (35%)
		CYCc	736..929	CDD:214485	102/192 (53%)
		Guanylate_cyc	763..950	CDD:278633	106/186 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920