DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and adcy1b

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001161822.1	Gene:	adcy1b / 569499	ZFINID:	ZDB-GENE-100805-1	Length:	1114	Species:	Danio rerio

Alignment Length:	440	Identity:	113/440 - (25%)
Similarity:	179/440 - (40%)	Gaps:	102/440 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   735 GDVYAFAIIMYEIFSRKGPFGQINFEPKEI------VDYVKKLPLKGEDPFRPEVESIIEAESCP 793
            |..|||...|....| ...|.::::.||.|      |.|:..|.|.|   ||          ...
Zfish   705 GAQYAFLCCMLGTLS-MALFLRVSWIPKTILLLLLLVLYITILELSG---FR----------RAS 755

  Fly   794 DYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLL 858
            .:.|..:|..       .|..|::   |...........:|..:.:...:|...|:   ||..:
Zfish   756 GWALLSVRGL-------EPLLSLL---LFSTAVALHSRQLDLKLRLDFLWATQAEE---ERDGM- 806

  Fly   859 CEEKMKTED--LLHRMLPQSVAEKLTMGQGVEPVSYDL-------VTIYFSDIVGFT----AMSA 910
              ||:|.::  :|..:||..||:...:.   .|.:.||       |.:.|:.|..|.    .:..
Zfish   807 --EKVKLDNKRILFNLLPVHVAQHFLLS---NPRNMDLYYQSYAQVGVLFASIPNFNDFYIELDG 866

  Fly   911 ESTPLQVVNFLNDLYTVFDRII--RGY-DVYKVETIGDAYMVVSGLPIKNGDR-------HAGEI 965
            .:..::.:..||::...||.::  ..| |:.|::|||..||...||....|.:       |...|
Zfish   867 NNMGVECLRLLNEIIADFDELMDKECYKDIEKIKTIGSTYMSAVGLVPTIGTKAKKSTATHLSTI 931

  Fly   966 ASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGE 1030
            |..|:|:...:.:  |.::......||:|::.|||||||:|...|:|.::|:|||.||||:|.|.
Zfish   932 ADFAIEMFDVLDE--INYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGV 994

  Fly  1031 ALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLF 1095
            ..||.::......|.   ..|....||.|::||||.::|::|.|
Zfish   995 PGKIQVTEDVYRLLQ---NNYDLMCRGNVSVKGKGQMLTYFLEG--------------------- 1035

  Fly  1096 SRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGSV 1145
                       .::.|.|:|.|..|...||...:.|.   .||.:..|||
Zfish  1036 -----------KAQDPGIRAPHHTGGLERRVHAIART---SSTQTKAGSV 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	22/97 (23%)
		HNOBA	<835..881	CDD:285003	12/47 (26%)
		CYCc	860..1052	CDD:214485	62/214 (29%)
		Guanylate_cyc	887..1074	CDD:278633	64/207 (31%)
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831
		CYCc	236..431	CDD:214485
		Guanylate_cyc	272..454	CDD:278633
		DUF1053	498..585	CDD:283888
		CYCc	806..1012	CDD:214485	62/216 (29%)
		Guanylate_cyc	839..1035	CDD:278633	62/200 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900