DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and si:dkey-206f10.1

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_009293230.1	Gene:	si:dkey-206f10.1 / 560719	ZFINID:	ZDB-GENE-041014-154	Length:	1187	Species:	Danio rerio

Alignment Length:	722	Identity:	159/722 - (22%)
Similarity:	266/722 - (36%)	Gaps:	220/722 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 YTSTVAAVVLGVLLFCSGVITMSIYRKWKIE-----------LEIEGLLWKI------------- 530
            :|.:|...|||:             :||:.:           ||..|:..:|
Zfish   488 HTGSVLCGVLGL-------------QKWQFDVWSWDVGIANMLEAGGIPGRIHISRATLDCLDGS 539

  Fly   531 -DPNEIKGYSGNE-----------IVSSPSKVSLMSAQSYGSR-----WTNQFVTSTGRLRGAVV 578
             ...:.:||..||           |......::.|.|:...:|     |..:.:.|..  .|:..
Zfish   540 FQTEDGRGYERNEFLRKHNIDTFLICHKEDDLNEMEAEHPKTRHNNRPWNKEILASFS--NGSYT 602

  Fly   579 RIKELKFPRK---RDISREIMK------EMRLLRELRHDNINS----FIGASVEPTRILLVTDYC 630
            ::     |..   |.:|:||.|      ::|....:|.::|..    |..|.:|
Zfish   603 QL-----PTSSACRSMSKEINKRIEHAIDLRSSERMRQEHITPVTLVFKDAHIE----------- 651

  Fly   631 AKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFG 695
                     |......|::|..:|:...|..::.:....|:          .|...::..|..|.
Zfish   652 ---------EKFSQVRDEMFKTNLVCSFIMLLLLMAVQALI----------PVPRMYLWTVLQFC 697

  Fly   696 LHEL-------RQCAENESIGEHQHYRNQLWRAPELLRN-----HIHGSQKGDVYAFAIIMYEIF 748
            |..|       ...||     |.:|       :|.:|:.     |.:.|.:..:...||.|
Zfish   698 LFLLGYLLLLVMVLAE-----EFKH-------SPGVLQQFCCWIHENNSMRNLLTITAIAM---- 746

  Fly   749 SRKGPFGQINF--------EPKEIVDYVKKLPLKGEDPFR----PEV---ESIIEAESCPDYV-- 796
                .||...|        |.|||.....:....|:.|..    |||   ..::...:|..::
Zfish   747 ----NFGMALFDMMWCNSSEMKEISTRETEGYKAGQKPLTACTYPEVFVLSGVVSMVTCAVFLRM 807

  Fly   797 -----------LACIRDCWAE--------DPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEK 842
                       :..:...:.|        ..:|....|  |:...:.:|   .:|:...|.|:..
Zfish   808 SSLLKLTILLFVVAVYTYFIEVSFHMLYVHQQEHEHLS--RSHFLRRKG---VSILLMAMFMIAV 867

  Fly   843 YANNLEDIVTERT----RLLCEEKMK--------TEDLLHRMLPQSVA----EKLTMGQGVEPVS 891
            ..|......|.|.    ||..:::::        .|.|||.:||..||    |:....|.:...|
Zfish   868 LYNGRRWEATTRLDFLWRLQAQQEVQEMRDLREHNECLLHNILPAHVARHFLERNRNDQELYSQS 932

  Fly   892 YDLVTIYFSDIVGFT----AMSAESTPLQVVNFLNDLYTVFDRII-RGY--DVYKVETIGDAYMV 949
            ||.|.:.|:.|.||.    ....:...::.:..||::...||.:: ..|  |:.|::|||..||.
Zfish   933 YDEVGVMFASIAGFNDYYEQKEIKHEGVECLKLLNEIIADFDELLEESYFLDIEKIKTIGSCYMA 997

  Fly   950 VSGLP------IKNGDRHAGEIASMAL---ELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVV 1005
            .|||.      :.|...|..|:...||   |.|..:.:|.:     ...:||:|:..|||||||:
Zfish   998 ASGLSPDKQSRVVNDWHHLSELVLFALAMQETLREINKHSM-----NNFQLRVGIAHGPVVAGVI 1057

  Fly  1006 GLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKG----KGD 1066
            |.|.|:|.::|.|||.||||:|.|.:.:|.:....:..|  ...|::.|.||.:.:||    ||.
Zfish  1058 GATKPQYDIWGMTVNLASRMDSTGVSGRIQVPEATRNIL--ADWGFVLELRGEIYIKGVSERKGR 1120

  Fly  1067 VVTWWLT 1073
            |.|::::
Zfish  1121 VRTYFIS 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	58/349 (17%)
		HNOBA	<835..881	CDD:285003	16/61 (26%)
		CYCc	860..1052	CDD:214485	68/219 (31%)
		Guanylate_cyc	887..1074	CDD:278633	67/207 (32%)
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:292831
		CYCc	343..538	CDD:214485	11/62 (18%)
		Guanylate_cyc	382..564	CDD:278633	15/88 (17%)
		DUF1053	<611..661	CDD:283888	13/69 (19%)
		CYCc	899..1097	CDD:214485	67/204 (33%)
		Guanylate_cyc	928..1126	CDD:278633	67/204 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810