Protein Alignment CG42637 and npr1a

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001038402.1
• Gene: npr1a / 560653
• ZFINID: ZDB-GENE-060503-539
• Length: 1067
• Species: Danio rerio
• Alignment Length: 1095
• Identity: 386/1095 - (35%)
• Similarity: 588/1095 - (53%)
• Gaps: 155/1095 - (14%)

  Fly    46 ISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGP---EGP-C- 105
            :..||..||::||.|||||...:|.|.:|.::....|.:.::..::...:...:.|   .|| |
Zfish    67 VGPALYWALEKVNSDPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDLKFSYNPWAFIGPGCD 131

  Fly   106 YVEAIVSQSR---NIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL--- 164
            |..:.|::..   .:|||:........:...:.....|...::.:.:|.:.|::.|:|.::|
Zfish   132 YSSSPVARFTTHWEVPMITSGARALGFNLYSSITNIGPTHKKLGEFVLRMHRHFGWDKHAMLMFN 196

  Fly   165 ---------YEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNT 220
                     |..|..|...:.:|..|..::..|..:..:                 .:.:|:::.
Zfish   197 DNKNDDRPCYFAVEGPYTQMREDNITADDLVFNEDEEPL-----------------RYDELLRDI 244

  Fly   221 MNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYS---------------EREAE 270
            .::.|:........:....|......| |.:.||...|:|:...|               :..|:
Zfish   245 SHKARVVYVCCKWETFRKLMVEFWRQG-FPQEEYAFFFIDLFGRSLQSHPARPWARGDADDNAAK 308

  Fly   271 KYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFV 335
            :..:.|..:|:..                     |...:|..|..:: |..:...||..     |
Zfish   309 EAFKSVKILTYRE---------------------PQNPEYKDFVSKL-KTEAMDMFNFN-----V 346

  Fly   336 ESNFSKFISIYAAYLYDSVKLYAWAV-DKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMS 399
            |.:....||   ...:|.|.||:.|: |.|.|..:|...|            |::..:.||||..
Zfish   347 EDSLMNLIS---GSFHDGVMLYSHALNDTMDRSGSRPPGD------------VVNKRMWNRTYHG 396

  Fly   400 ITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEE-----HPEYKLING 459
            :|| .:::|:.||.|.:|::       |:.::....:|.:|.|   :.|.:     .|..|
Zfish   397 VTG-LVQLDENGDREIDFAL-------WDMTDTKTGDYQIVSV---YNGSQKQMILEPGMK---- 446

  Fly   460 SIDWPSGGEKPADEPMCGFANE----LCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIE 520
             :.|.. |..|.|.|.|||.|:    |.|....|...::....:.:::.   .:|:.||||.|:|
Zfish   447 -VHWLK-GRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIV---TVTVFIYRKLKLE 506

  Fly   521 LEIEGLLWKIDPNEIKGYSGNEIV-SSPSKVSL-MSAQSYGSRWTN----QFVTSTGRLRGAVVR 579
            .|:...||::...:|:..:..::: .:.||::: :...:|||..|.    |....||..:|.:..
Zfish   507 NELTAQLWRVHWEDIQMSNTEKVLRRACSKLTISLRGSNYGSLLTMDGNFQIYAKTGYYKGNITA 571

  Fly   580 IKELKFPRKR-DISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENED 643
            ||.:.  :|| :::|:::.|::.:|:::::::..||||.::|..|.::|:||.:|||.|::|:|.
Zfish   572 IKYVN--KKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEG 634

  Fly   644 IKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESI 708
            |.||.:|..|||:|::|||.::|||.:|.|||||||||||.||::|::||:||....:.:..:.:
Zfish   635 ITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKDSNLDDV 699

  Fly   709 GEHQHYRNQLWRAPELLRNH---IHGSQKGDVYAFAIIMYEIFSRKGPF---GQINFEPKEIVDY 767
              |..|..|||.||||||..   ..|:||||||:|.||:.|:...||.|   |.. ..||||::.
Zfish   700 --HAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLEGPC-LSPKEIIER 761

  Fly   768 VKKLPLKGEDPF-RPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKN 831
            |    ::|..|: ||.:.....:|.....:|.    ||:||..|||:||.|:..|:|...|...|
Zfish   762 V----VEGRWPYLRPLLCPQSHSEEMGQLMLR----CWSEDVNERPDFSQIKVLLRKNNCGYGSN 818

  Fly   832 IMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVT 896
            |:|.::..||:||||||::|.|||:...|||.|.|.||:::||.||||:|..|:.|:..::|.||
Zfish   819 ILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVT 883

  Fly   897 IYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRH 961
            |||||||||||:||||||::||..||||||.||.||..:|||||||||||||||||||::||..|
Zfish   884 IYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLH 948

  Fly   962 AGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRME 1026
            |.|||.|:|.||.||...||.||||..|:||||:|:|||.||||||.||||||||||||||||||
Zfish   949 AREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRME 1013

  Fly  1027 SNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG--ANENA 1079
            |||||||||:|...:..|.:. ..:..|.||.|.|||||.:.|:||.|  ::.||
Zfish  1014 SNGEALKIHVSEATRAVLQEF-NCFQLELRGDVEMKGKGRMRTYWLLGEISSNNA 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	85/434 (20%)
		PK_GC-A_B	543..827	CDD:270944	114/297 (38%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	130/191 (68%)
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:380608	88/457 (19%)
		PK_GC-A_B	540..814	CDD:270944	112/286 (39%)
		HNOBA	<820..868	CDD:462234	26/47 (55%)
		CYCc	847..1032	CDD:214485	129/184 (70%)