DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42637 and Adcy1

DIOPT Version :9

Sequence 1:NP_001007096.1 Gene:CG42637 / 40153 FlyBaseID:FBgn0261360 Length:1525 Species:Drosophila melanogaster
Sequence 2:NP_033752.1 Gene:Adcy1 / 432530 MGIID:99677 Length:1118 Species:Mus musculus


Alignment Length:297 Identity:75/297 - (25%)
Similarity:142/297 - (47%) Gaps:38/297 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   862 KMKTEDLLHRMLPQSVAEKLTM----GQGVEPVSYDLVTIYFSDIVGFT----AMSAESTPLQVV 918
            |:..:.:|..:||..||:...|    ...:...||..|.:.|:.|..|.    .:...:..::.:
Mouse   829 KLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECL 893

  Fly   919 NFLNDLYTVFDRII-RGY--DVYKVETIGDAYMVVSGLPIKNGDR-------HAGEIASMALELL 973
            ..||::...||.:: :.:  |:.|::|||..||...||....|.|       |...:|..|:::.
Mouse   894 RLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLCTLADFAIDMF 958

  Fly   974 HAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISN 1038
            ..:.:  |.::......||:|::.|||||||:|...|:|.::|:|||.||||:|.|...:|.::.
Mouse   959 DVLDE--INYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTE 1021

  Fly  1039 KCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANEN--------AIQKKLVDM-----MDM 1090
            :....|.:....::.  ||.|::||||:::|::|.|..:.        .:::::...     ...
Mouse  1022 EVHRLLKRCSYQFVC--RGKVSVKGKGEMLTYFLEGRTDGNSSHGRTFRLERRMCPYGRGGGQAR 1084

  Fly  1091 PPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQS 1127
            .|||.  |...|.:.| ...|:..:.:...|.:.:::
Mouse  1085 RPPLC--PAAGPPVRP-GLPPAPTSQYLSSTAAGKEA 1118

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42637NP_001007096.1 PBP1_Speract_GC_like 26..445 CDD:107365
ANF_receptor 48..412 CDD:279440
PK_GC-A_B 543..827 CDD:270944
HNOBA <835..881 CDD:285003 6/18 (33%)
CYCc 860..1052 CDD:214485 57/207 (28%)
Guanylate_cyc 887..1074 CDD:278633 59/200 (30%)
Adcy1NP_033752.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
AC_N <158..291 CDD:292831
CYCc 257..452 CDD:214485
Guanylate_cyc 293..475 CDD:278633
Interaction with calmodulin. /evidence=ECO:0000250 492..519
CYCc 825..1036 CDD:214485 57/208 (27%)
Guanylate_cyc 858..1055 CDD:278633 59/200 (30%)
Interaction with calmodulin. /evidence=ECO:0000250 1023..1046 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1079..1118 8/41 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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