DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and Ac76E

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster

Alignment Length:	829	Identity:	177/829 - (21%)
Similarity:	289/829 - (34%)	Gaps:	248/829 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 NSFIGASVEPTRILLVTDYCAK------GSLYDIIEN------EDIKLDDLF------------- 650
            |..:.|....|:...:|...|:      .||.|:.|.      |||.|:||:
  Fly    20 NLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIHLNDLYTRYRQRLRKSLFR 84

  Fly   651 ----------IASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQ--------------- 690
                      :.|:|..::.|...:....||....:..|  ::|:   ||
  Fly    85 SGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGS--ILTA---LQFPAVLSSPAAALAFA 144

  Fly   691 -VTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPF 754
             ||.|.|..:.....:|             .||.            .:||..:.::.:.....|
  Fly   145 IVTTFSLGTIAAITGDE-------------LAPL------------PMYALFLCIHSMLPISWP- 183

  Fly   755 GQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRN 819
                      |..|..|       |...:..:....:.|||.               |...::..
  Fly   184 ----------VSVVLAL-------FMTAIHIVYRIGTSPDYA---------------PNLPMLFG 216

  Fly   820 RLKKMRGGKTKNIMDQMME--MMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLT 882
            .:..:.......:..::|.  ...:..:.....:.:|.:|.||.:.: |.||..::|..:|.::.
  Fly   217 EIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQ-EQLLLSVIPAYIAAEVK 280

  Fly   883 M--------------GQGVEPVS--YDL-------VTIYFSDIVGFTAMSAESTPLQVVNFLNDL 924
            .              ||.....:  ::|       |||.|:|||.||.:|:..|...:|..||||
  Fly   281 RSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDL 345

  Fly   925 YTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETL 989
            :..||:|.:.....:::.:||.|..||||||.. .:||....:|.|:::.|::..|.|...|  :
  Fly   346 FGRFDQIAQENQCLRIKILGDCYYCVSGLPISR-PQHATNCVNMGLQMIDAIRHVREATGIN--V 407

  Fly   990 KLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITE 1054
            .:|||:|||.|:.||:||...::.::.|.|..|:.|||.|.|.::||:   |..||.||..:..|
  Fly   408 DMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHIT---KQTLDFLGDKFEVE 469

  Fly  1055 KRGLVNMKGKGDVVTWWLTGANENA--IQKKLVDMMDMPPP---LFSRPR---------KSP--- 1102
                     :|:       |.|.:|  ...|:...:.:||.   .:|.||         .||
  Fly   470 ---------QGE-------GGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTE 518

  Fly  1103 -----------------------------------KLNPDSRQPSIQAMHFCGTGSRRQSTVPRA 1132
                                               |::|.|.......:| ....|....::...
  Fly   519 ETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLH-APLASAASMSIKEL 582

  Fly  1133 MDGESTYSLQGSVRESPRMVSKRDRD---RERPPINGLGAGHFVGG------ALLESAQASLSTL 1188
            .:.|.......:|.| |.|  .||:|   .:.|..||   ||...|      ::.:||..||..
  Fly   583 SEEEDEADEATAVTE-PLM--HRDQDGKNDKEPKANG---GHRGSGDSAASESVAKSAALSLPA- 640

  Fly  1189 NHSETNETNCDMDGGSGGVSGSGSGLVRQPNALHKPLAMVRPHRIISAAQLPQLGDNDDDSADTL 1253
                  :....|.|...|:|.||:      .|.....|.|.|   .:||.......|....|:..
  Fly   641 ------DDLLSMSGSESGISNSGA------QAQSSNPASVTP---TAAAPAGGAASNSLTVAEAP 690

  Fly  1254 LRESRSLDPMPMQQL--RKRHDRVKLPPSKLSKNNSRSLDTGVSLISGN 1300
            .|..|.|....:...  |:|.....:...|||.::..|..:....::.|
  Fly   691 ERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRN 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	42/266 (16%)
		HNOBA	<835..881	CDD:285003	10/47 (21%)
		CYCc	860..1052	CDD:214485	71/214 (33%)
		Guanylate_cyc	887..1074	CDD:278633	65/195 (33%)
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	40/285 (14%)
		CYCc	259..467	CDD:214485	71/214 (33%)
		Guanylate_cyc	311..469	CDD:278633	62/163 (38%)
		BASP1	510..667	CDD:283191	32/176 (18%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740