Protein Alignment CG42637 and GUCY2F

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001513.2
• Gene: GUCY2F / 2986
• HGNCID: 4691
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1150
• Identity: 378/1150 - (32%)
• Similarity: 562/1150 - (48%)
• Gaps: 173/1150 - (15%)

  Fly     9 LLLLSVAVRDCSNHRTVLTVGYLTALTG----DLKTRQGLAISGALTMALDEVNKDPNLLPNVYL 69
            |.||||    .|..:.|.|:.|...:.|    |....:.|. ..|..:|::.:|:||:      .
Human    36 LCLLSV----MSLPQQVWTLPYKIGVVGPWACDSLFSKALP-EVAARLAIERINRDPS------F 89

  Fly    70 DLRWN--------DTKGDTVLATKAITEMICDGIATIFGPEGPCYVEA--IVSQSRNIPMISYKC 124
            ||.::        |.:....|::......:..|   ..||..|.|.||  ::..|.:..:.|:.|
Human    90 DLSYSFEYVILNEDCQTSRALSSFISHHQMASG---FIGPTNPGYCEAASLLGNSWDKGIFSWAC 151

  Fly   125 AEYRAS---AIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY--EDVW----SPVADLLKDQA 180
            ..|...   :.|||:||.|...:|   |:.:::|:.|....::.  ||:|    :.||..|:...
Human   152 VNYELDNKISYPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHG 213

  Fly   181 TKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLV----DFMS 241
            ....:.:...|.....|                 :.:|......||.:.:...:|.:    ..|.
Human   214 LPVGVVLTTGQDSQSMR-----------------KALQRIHQADRIRIIIMCMHSALIGGETQMH 261

  Fly   242 SMETAG--LFARGEYMVIFVDMMVYS---EREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVV 301
            .:|.|.  ....|.|:.:..|.::||   :....:.||        :|....|.::    ::|.:
Human   262 LLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLR--------NNPKLREAYD----AVLTI 314

  Fly   302 ASTPPTKDYIQ-FTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKML 365
            ......|.:.| ||:...:.        |||.   :..|.:...::.. :|:|:...|.|::..:
Human   315 TVESQEKTFYQAFTEAAARG--------EIPE---KLEFDQVSPLFGT-IYNSIYFIAQAMNNAM 367

  Fly   366 REETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITG--SKIKIDQYGDSEGNFSVLAYKPHKWN 428
            :|               ||.....:::::...|...|  ..::.|..|:....:.:|.....:|.
Human   368 KE---------------NGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWE 417

  Fly   429 NSNNMPCNYHMVPVAYFHQGEEHPEYKLINGS-IDWPSGGEKPADEPMCGFA-NELCKKD-DTHY 490
            ..:....:..|             |.....|: |.:| ||..|..:..|.|| .::|... |..:
Human   418 LHSTYTVDMEM-------------ELLRFGGTPIHFP-GGRPPRADAKCWFAEGKICHGGIDPAF 468

  Fly   491 TSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEG----LLWKIDPNEIKGYSGNEIVSSPSKVS 551
            ...|...:|..||..:|.......|..||:| |:|    ||...|...|..:.|:: ..|.:.||
Human   469 AMMVCLTLLIALLSINGFAYFIRRRINKIQL-IKGPNRILLTLEDVTFINPHFGSK-RGSRASVS 531

  Fly   552 LMSAQSYGSRWTNQFVTSTGRL-------------RGAVVRIKELK---FPRKRDISREIMKEMR 600
            ........|..:.:...|:|.|             .|..|.:|:..   |...:.|.........
Human   532 FQITSEVQSGRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFE 596

  Fly   601 LLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYI 665
            ::::|||:|||..:|...:.....:||::|::|||.||:.|:|:|||.:|.:||:.||||||.|:
Human   597 MMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYL 661

  Fly   666 HNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLH---ELRQCAENESIGEHQHYRNQLWRAPELL-- 725
            |:.:.| ||.|||.||||..|::|:|||:|.:   |:.:.:|.||..|     ..||.|||||
Human   662 HHREFV-HGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSME-----ELLWTAPELLRA 720

  Fly   726 -RNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEA 789
             |....||..||||:|||||.|:..|..||..::...:||::.:||.|        |....::..
Human   721 PRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPP--------PVYRPVVPP 777

  Fly   790 ESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTER 854
            |..|...|..::.||||..|:||.|..|.|:.|....||..||:|.|:.|:|:|::||||::.||
Human   778 EHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRER 842

  Fly   855 TRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVN 919
            |..|..||.|||.||.:|||.||||.|..|..|||..:||||:|||||||||.:||.|.|::||:
Human   843 TEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVD 907

  Fly   920 FLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHR 984
            .||||||:||.||..:||||||||||||||.||||.:||.|||.|||:|:|::|.:|...::.|.
Human   908 LLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHM 972

  Fly   985 PNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGG 1049
            |...:::|||:|:||||||||||||||||||||||||||||||.|...:||:|......|..|..
Human   973 PEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSE 1037

  Fly  1050 GYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPL 1094
            ||..|.||...:||||...|:||.|      :|..:..:.:|||:
Human  1038 GYEVELRGRTELKGKGTEETFWLIG------KKGFMKPLPVPPPV 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	82/453 (18%)
		PK_GC-A_B	543..827	CDD:270944	107/305 (35%)
		HNOBA	<833..881	CDD:462234	27/47 (57%)
		CYCc	860..1052	CDD:214485	121/191 (63%)
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	81/462 (18%)
		Protein Kinases, catalytic domain	545..815	CDD:473864	103/283 (36%)
		HNOBA	<824..869	CDD:462234	26/44 (59%)
		CYCc	848..1040	CDD:214485	121/191 (63%)