DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and GUCY2C

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	1260	Identity:	342/1260 - (27%)
Similarity:	531/1260 - (42%)	Gaps:	352/1260 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RDCSN---HRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNL----LPNVYLDLRWN 74
            ::|.|   ..:||.:|. :|....||..:            |.||:...:    |.|..|::..|
Human    28 QNCHNGSYEISVLMMGN-SAFAEPLKNLE------------DAVNEGLEIVRGRLQNAGLNVTVN 79

  Fly    75 DT----------KGDTVLATKAITEMICDGI-------------ATIFGPEGPC-------YVEA 109
            .|          .||...:|       |:|:             ..:.||.  |       |::.
Human    80 ATFMYSDGLIHNSGDCRSST-------CEGLDLLRKISNAQRMGCVLIGPS--CTYSTFQMYLDT 135

  Fly   110 IVSQSRNIPMIS-----YKCAEYRASAIPTFARTEPPDTQVVKSLLAL-------LRYYAWNKFS 162
            .:|    .||||     ..| :|:    .|..|...|..:::..|:..       .:.|:|:. |
Human   136 ELS----YPMISAGSFGLSC-DYK----ETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWST-S 190

  Fly   163 ILYEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWY------------- 214
            .:|                 :|.|                :..||    :||
Human   191 YVY-----------------KNGT----------------ETEDC----FWYLNALEASVSYFSH 218

  Fly   215 ---------------QLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVY 264
                           .::.:...::.:.:..|....|.........|     .:.::|.||:.
Human   219 ELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVA-----EDIVIILVDLF-- 276

  Fly   265 SEREAEKYLRRVDQIT---FMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPF 326
                .::|..  |.:|   :|.|             :||:..:|...
Human   277 ----NDQYFE--DNVTAPDYMKN-------------VLVLTLSPGNS------------------ 304

  Fly   327 NLEIPRLFVESNFSKFIS-----IYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTR 386
                   .:.|:||:.:|     ...||| :.:.|:.    .||:          ||  ..||..
Human   305 -------LLNSSFSRNLSPTKRDFALAYL-NGILLFG----HMLK----------IF--LENGEN 345

  Fly   387 VIDT----IIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAY-FH 446
            :...    ..:|.|:....| .:.:|.:||.:... ||.|        .::....:.|.:.| .|
Human   346 ITTPKFAHAFRNLTFEGYDG-PVTLDDWGDVDSTM-VLLY--------TSVDTKKYKVLLTYDTH 400

  Fly   447 QGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTH----------YTSTVAAVVLGV 501
            ..:.:|        :|.         .|...:.|.....|.|.          :|.|.|.|:|
Human   401 VNKTYP--------VDM---------SPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLL-- 446

  Fly   502 LLFCSGVITMSIYRKWKIELEIEGLLWK-IDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQ 565
            ||     :.:.:.||::.:.|:....|. |.|..|.....||    .:.|||.
Human   447 LL-----VALLMLRKYRKDYELRQKKWSHIPPENIFPLETNE----TNHVSLK------------ 490

  Fly   566 FVTSTGRLRGAVVRIKELKFPRKRDISREIMK-----------EMRLLRELRHDNINSFIGASVE 619
              ....:.|..:.|:::.|:.:||.|.:::..           |:..|.::.:.|:..|.|....
Human   491 --IDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKL 553

  Fly   620 PTRILLVTDYCAKGSLYDIIENEDIK------LDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKS 678
            .|.|..|.:||.:|||.::: |:.|.      :|..|..|:::|:.|||.|:|:|:...||.|||
Human   554 DTMIFGVIEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKS 617

  Fly   679 SNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAII 743
            :||||.||.::::||||.:.:..            .:..||.|||.|| ..:.|||||||::.||
Human   618 TNCVVDSRMVVKITDFGCNSILP------------PKKDLWTAPEHLR-QANISQKGDVYSYGII 669

  Fly   744 MYEIFSRKGPFGQINFEPK-EIVDYVKKLPLKGEDPFRPE--VESIIEAESCPDYVLACIRDCWA 805
            ..||..||..|..::...: |.:..|:.  ..|..||||:  :|:..|.| ...|:|  :::||.
Human   670 AQEIILRKETFYTLSCRDRNEKIFRVEN--SNGMKPFRPDLFLETAEEKE-LEVYLL--VKNCWE 729

  Fly   806 EDPEERPEFSVIRNRLKKMRG----GKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTE 866
            ||||:||:|..|...|.|:.|    .|.::.||.::..::.|:.|||.:|.|||:|...|:.:.:
Human   730 EDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRAD 794

  Fly   867 DLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRI 931
            .|...:||:.|.:.|.....|||..|:.||||||||||||.:...|||::||:.|||:|..||.|
Human   795 RLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHI 859

  Fly   932 IRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMH 996
            :..:||||||||||||||.||||.:||:|||.:||.||||:|..:....:.|.|...:.:|||:|
Human   860 VDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVH 924

  Fly   997 TGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNM 1061
            :||..|||||:.|||||||||||||||||||.|..|:||:|......|.:....::.|.||...:
Human   925 SGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYL 989

  Fly  1062 KGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQ 1126
            ||:|:..|:||||..:....      :..||.:.::.|...:.: |....|:|.....|..|::.
Human   990 KGRGNETTYWLTGMKDQKFN------LPTPPTVENQQRLQAEFS-DMIANSLQKRQAAGIRSQKP 1047

  Fly  1127 STVP------------RAMDGESTY 1139
            ..|.            ...|.||||
Human  1048 RRVASYKKGTLEYLQLNTTDKESTY 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	82/505 (16%)
		ANF_receptor	48..412	CDD:279440	70/449 (16%)
		PK_GC-A_B	543..827	CDD:270944	95/307 (31%)
		HNOBA	<835..881	CDD:285003	14/45 (31%)
		CYCc	860..1052	CDD:214485	102/191 (53%)
		Guanylate_cyc	887..1074	CDD:278633	105/186 (56%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364	87/543 (16%)
		PK_GC-C	480..750	CDD:270946	96/306 (31%)
		Pkinase_Tyr	502..745	CDD:285015	88/261 (34%)
		CYCc	788..979	CDD:214485	102/190 (54%)
		Guanylate_cyc	815..1002	CDD:278633	105/186 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820