DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and GUCY1A1

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens

Alignment Length:	673	Identity:	174/673 - (25%)
Similarity:	269/673 - (39%)	Gaps:	203/673 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   579 RIKELKFPRKRD--------------ISREIMKE------MRLLRELRHDNINSFIGASVEP--- 620
            :|||.:...:|:              :..|::||      .::..| ..:||...:|.:::.
Human   101 KIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYE-EDENILGVVGGTLKDFLN 164

  Fly   621 --TRILLVTDYCAKGSLYDIIENEDI----KLDDLFIASLIHDLIKGMIYI----HNSQLVYHGN 675
              :.:|..:.:|.:......:|:..|    |.||     .:|      :|.    ..:.|:..|.
Human   165 SFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDD-----FLH------VYYFFPKRTTSLILPGI 218

  Fly   676 LKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDV--- 737
            :|::..|      |..|:..:..:..|..|:.    ..:.||    |.||.:....|.|..:
Human   219 IKAAAHV------LYETEVEVSLMPPCFHNDC----SEFVNQ----PYLLYSVHMKSTKPSLSPS 269

  Fly   738 --YAFAIIMYEIFSRKGPFGQINFEPKEIVDY---VKKLPLKGEDPFRPEVESIIEAESCPDYVL 797
              .:..:|...:|.:..||..:..:...|:.:   :::|..:.:...:|..|...|       :|
Human   270 KPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFE-------IL 327

  Fly   798 ACIRDCWAEDPEERPEFS----------VIRNRLKKMRGGKTKNIMD---QMMEMMEKYA----- 844
            .         |:....||          |:|.|.......|:..:||   ||:.::|..|
Human   328 T---------PKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLG 383

  Fly   845 -----------------------NNLEDIVT--ERTR---------------------LLCEEKM 863
                                   |.|.|:|.  |:.|                     .|.|||.
Human   384 SPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKK 448

  Fly   864 KTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVF 928
            ||.|||..:.|..||::|..||.|:...:..||:.|||||||||:.::.:||||:..||.|||.|
Human   449 KTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRF 513

  Fly   929 DRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRI 993
            |:.....||||||||||||.|..||. |..|.||.:||.|||:::....:....|  .|.:|:||
Human   514 DQQCGELDVYKVETIGDAYCVAGGLH-KESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRI 575

  Fly   994 GMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGL 1058
            |:|:|.|.|||||:.||||||||:.|..|::.||.....||::|
Human   576 GLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS--------------------- 619

  Fly  1059 VNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPD--SRQPSIQAMHFC-- 1119
                    ..|:.|              :.|.|..:|: ||...:|.|:  |..|.|  .||.
Human   620 --------PTTYRL--------------LKDCPGFVFT-PRSREELPPNFPSEIPGI--CHFLDA 659

  Fly  1120 ---GTGSRRQSTVPRAMDGESTY 1139
               ||.|:.........||.:.:
Human   660 YQQGTNSKPCFQKKDVEDGNANF 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	51/298 (17%)
		HNOBA	<835..881	CDD:285003	22/96 (23%)
		CYCc	860..1052	CDD:214485	90/191 (47%)
		Guanylate_cyc	887..1074	CDD:278633	78/186 (42%)
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	41/204 (20%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	83/217 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810