DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	437	Identity:	135/437 - (30%)
Similarity:	194/437 - (44%)	Gaps:	137/437 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   699 LRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPK- 762
            :::| ||.:|                ::|...|:.:  |.|...|....|.|..|| .:.|:|.
Human   293 IKEC-ENTNI----------------MKNLPQGTSQ--VPADLRISINTFCRAFPF-HLMFDPSM 337

  Fly   763 ---EIVDYVKK-------LPLKGEDPFR---PEV----ESIIEAESCPDYVLACIRDCWAEDPEE 810
               ::.:.::|       ..||.||.|.   |:|    |.::...|.| :|:           ..
Human   338 SVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTP-FVI-----------RT 390

  Fly   811 RPEFSVIRNRLKKM-------------------------------RG------------------ 826
            :||.|...|:.|.|                               ||
Human   391 KPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILV 455

  Fly   827 GKTKNIMDQMMEMMEKYANNLEDIVTERT-RLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPV 890
            |:.....|.:.:.|:|....|     ||| :.|.|||.||.|||:.:.|..||::|..||.|:..
Human   456 GEQAKAQDGLKKRMDKLKATL-----ERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQAR 515

  Fly   891 SYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPI 955
            .:|.||:.|||||||||:.|:.||:||::.||:|||.||......|:||||||||||.|.:||..
Human   516 KFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHR 580

  Fly   956 KNGDRHAGEIASMALELLHAVK------------------------------QHRIAHRPNETLK 990
            |: ..||..||.|||:::...:                              ||: :.....|.|
Human   581 KS-LCHAKPIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQ-SETDLGTEK 643

  Fly   991 LRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS 1037
            :|||:|:|.|:|||||:.||||||||:.|..||:.||.....:|::|
Human   644 MRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVS 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	35/194 (18%)
		HNOBA	<835..881	CDD:285003	18/46 (39%)
		CYCc	860..1052	CDD:214485	91/208 (44%)
		Guanylate_cyc	887..1074	CDD:278633	77/181 (43%)
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002
		HNOBA	316..503	CDD:285003	45/204 (22%)
		CYCc	485..705	CDD:214485	91/208 (44%)
		Guanylate_cyc	514..729	CDD:278633	76/179 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810