DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	1199	Identity:	340/1199 - (28%)
Similarity:	521/1199 - (43%)	Gaps:	291/1199 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ALTMALDEVNKDPNLLPNVYLDLRWNDT----------KGDTVLATKAITEMICDGI-------- 95
            |:...||.|.|   .|....|::..|.|          .||...:|       |:|:
  Rat    56 AVEEGLDIVRK---RLREAELNVTVNATFIYSDGLIHKSGDCRSST-------CEGLDLLREITR 110

  Fly    96 -----ATIFGPEGPC---YVEAIVSQSRNIPMIS-----YKCAEYRASAIPTFARTEPPDTQVVK 147
                 ..:.||.  |   ..:..:....|.||||     ..| :|:    .|..|..||..:::.
  Rat   111 DRKMGCVLMGPS--CTYSTFQMYLDTELNYPMISAGSFGLSC-DYK----ETLTRILPPARKLMY 168

  Fly   148 SLL-------ALLRYYAWNKFSILYEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQML 205
            .|:       |..:.::||. |.:|::...|.
  Rat   169 FLVDFWKVNNAPFKTFSWNS-SYVYKNGSEPE--------------------------------- 199

  Fly   206 DCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAE 270
            ||    :||               |.|..:.|.:.|.            ::.|.|::..||:..|
  Rat   200 DC----FWY---------------LNALEAGVSYFSE------------VLSFKDVLRRSEQFQE 233

  Fly   271 KYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPP------TKDYIQFTKQVQKYSSK------ 323
            ..:.|..:...:..|.:.|.|..:...|.|...|..      :..|.:...:..:|...
  Rat   234 ILMGRNRKSNVIVMCGTPETFYNVKGDLKVADDTVVILVDLFSNHYFEDDTRAPEYMDNVLVLTL 298

  Fly   324 PPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVI 388
            ||... |....|...|....|.::....:...|:...:...|.....|.|..  |..|
  Rat   299 PPEKF-IANASVSGRFPSERSDFSLAYLEGTLLFGHMLQTFLENGESVTTPK--FARA------- 353

  Fly   389 DTIIKNRTYMSITGSKIKIDQYGDSEG------------NFSVL-AYKPHKWNNSNNMPCNYHMV 440
               .:|.|:..:.| .:.:|..||.:.            .:.|| ||..|| |.:         :
  Rat   354 ---FRNLTFQGLEG-PVTLDDSGDIDNIMCLLYVSLDTRKYKVLMAYDTHK-NQT---------I 404

  Fly   441 PVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCG--------FANELCKKDDTHYTSTVAAV 497
            |||      ..|.:...|..:        |.|.|..|        |              |:..:
  Rat   405 PVA------TSPNFIWKNHRL--------PNDVPGLGPQILMIAVF--------------TLTGI 441

  Fly   498 VLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNE-IKGYSGNEIVSSPSKVSLMSAQSYGSR 561
            |:.:||     |.:.:.||::.:.|:....|...|:| |.....||    .:.|||.
  Rat   442 VVVLLL-----IALLVLRKYRRDHELRQKKWSHIPSENIFPLETNE----TNHVSLK-------- 489

  Fly   562 WTNQFVTSTGRLRGAVVRIKELKFPRKRDISREI---------MKEMRLLRELRHD--NINSFIG 615
                  ....|.|..:.|:::.|:.:|:.|.:::         .:::.|.:.|:.|  |:..|.|
  Rat   490 ------IDDDRRRDTIQRVRQCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYG 548

  Fly   616 ASVEPTRILLVTDYCAKGSLYDIIENEDIK------LDDLFIASLIHDLIKGMIYIHNSQLVYHG 674
            .....|||..|.:||.:|||.::: |:.|.      :|..|..|:::|:.|||.|:|:|::..||
  Rat   549 TVKLDTRIFGVVEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHG 612

  Fly   675 NLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYA 739
            .|||:||||.||.::::||||.:.:..            .:..||.|||.||.... |||||||:
  Rat   613 RLKSTNCVVDSRMVVKITDFGCNSILP------------PKKDLWTAPEHLRQATI-SQKGDVYS 664

  Fly   740 FAIIMYEIFSRKGPFGQINF-EPKEIVDYVKKLPLKGEDPFRPE--VESIIEAESCPDYVLACIR 801
            |:||..||..||..|..::. :..|.:..|:.  ..|..||||:  :|:..|.| ...|:|  ::
  Rat   665 FSIIAQEIILRKETFYTLSCRDQNEKIFRVEN--SYGTKPFRPDLFLETADEKE-LEVYLL--VK 724

  Fly   802 DCWAEDPEERPEFSVIRNRLKKMRG----GKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEK 862
            .||.||||:||:|..|.:.|.|:.|    .|.::.||.::..::.|:.|||.:|.|||:|...|:
  Rat   725 SCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAER 789

  Fly   863 MKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTV 927
            .:.:.|...:||:.|.:.|.....|||..|:.||||||||||||.:...|||::||:.|||:|..
  Rat   790 DRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKS 854

  Fly   928 FDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLR 992
            ||:|:..:||||||||||||:|.||||::||:|||.:|:.|||::|..:....:.|.|...:.:|
  Rat   855 FDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHLPGLPVWIR 919

  Fly   993 IGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRG 1057
            ||:|:||..|||||:.|||||||||||||||||||.|..|:||:|:.....|.:....::.|.||
  Rat   920 IGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRG 984

  Fly  1058 LVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTG 1122
            ...:||:|...|:||||..:....      :..||.:.::.|...:.: |....::|.....|..
  Rat   985 ETYLKGRGTETTYWLTGMKDQEYN------LPTPPTVENQQRLQTEFS-DMIVSALQKRQASGVK 1042

  Fly  1123 SRRQSTVP------------RAMDGESTY 1139
            |||.:.|.            ...|.:|||
  Rat  1043 SRRPTRVASYKKGFLEYMQLNNSDHDSTY 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	85/458 (19%)
		ANF_receptor	48..412	CDD:279440	73/412 (18%)
		PK_GC-A_B	543..827	CDD:270944	98/307 (32%)
		HNOBA	<835..881	CDD:285003	14/45 (31%)
		CYCc	860..1052	CDD:214485	99/191 (52%)
		Guanylate_cyc	887..1074	CDD:278633	102/186 (55%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	86/469 (18%)
		PKc_like	479..749	CDD:304357	99/306 (32%)
		STYKc	501..744	CDD:214568	90/261 (34%)
		CYCc	787..978	CDD:214485	99/190 (52%)
		Guanylate_cyc	814..1001	CDD:278633	102/186 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820