DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001257640.1	Gene:	Gucy1b2 / 25206	RGDID:	2770	Length:	742	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	138/380 - (36%)
Similarity:	204/380 - (53%)	Gaps:	63/380 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 KEIVDYVKK----LPLKGE----DPFR-------PEVESIIEAESCPDYVLACIRDCWAED--PE 809
            ||::...:|    |.|:|:    :..|       |::.|:.|.|....::         .|  |.
  Rat   338 KEMMPKARKSQPMLKLRGQMIWMESLRCMIFMCSPKLRSLQELEESKMHL---------SDIAPH 393

  Fly   810 ERPEFSVIRN--RLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRM 872
            :.....::.|  ||.:|          ::...:||....|..:    :..|..||.|||.||:.|
  Rat   394 DTTRDLILLNQQRLAEM----------ELSCQLEKKKEELRVL----SNHLAIEKKKTETLLYAM 444

  Fly   873 LPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDV 937
            ||:.||.:|..|:.|....::..||.|||:|.||.:.|...|:|:||.||.:|:.|||:...:||
  Rat   445 LPEHVANQLKEGRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDV 509

  Fly   938 YKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRP--NETLKLRIGMHTGPV 1000
            |||||||||||||.|:|:. .:.||..:|:.||.:..:.|:   ...|  .|.:::|:|:|||||
  Rat   510 YKVETIGDAYMVVGGVPVP-VESHAQRVANFALGMRISAKE---VMNPVTGEPIQIRVGIHTGPV 570

  Fly  1001 VAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKG 1065
            :|||||..|||||||||||||||||||:|...|:|:|.....||.  ..|:...:||.:.:||||
  Rat   571 LAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALK--NKGFEIVRRGEIEVKGKG 633

  Fly  1066 DVVTWWLTGANENAIQKKLVDMMDMP--------PPLFSRPRKSPKL--NPDSRQ 1110
            .:.|::|. .|.||.:.:::.....|        |.  ::.||||.:  |.|.:|
  Rat   634 KMTTYFLI-QNLNATEDEIMGRPSAPADGKEVCTPG--NQVRKSPAVPRNTDHQQ 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	17/83 (20%)
		HNOBA	<835..881	CDD:285003	16/45 (36%)
		CYCc	860..1052	CDD:214485	97/193 (50%)
		Guanylate_cyc	887..1074	CDD:278633	91/188 (48%)
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002
		HNOBA	267..453	CDD:285003	33/137 (24%)
		CYCc	432..622	CDD:214485	97/195 (50%)
		Guanylate_cyc	459..642	CDD:278633	91/189 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810