Protein Alignment CG42637 and Gucy1b2

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_011243363.2
• Gene: Gucy1b2 / 239134
• MGIID: 2660873
• Length: 829
• Species: Mus musculus
• Alignment Length: 563
• Identity: 172/563 - (30%)
• Similarity: 251/563 - (44%)
• Gaps: 141/563 - (25%)

  Fly   692 TDFGLHELRQCAENESIGEHQHY--------RNQLWRAPELLR----NHIHGSQK---------- 734
            ||..:..|....|.|..|:.:|.        |.|: |..::.|    .:|...|:
Mouse   270 TDVAMSILDMNEEVERTGKKEHVVFLVVQKARRQI-RGAKVNRPRDSENIQAKQESLQGTLLRKK 333

  Fly   735 ----------GDVYAFAIIMYEIFSRKGPFGQINFEP---------KEI--------VDYVKKLP 772
                      |:....|::...:...|||.|. .|:|         :|:        |.:.:.|.
Mouse   334 ERYLSIPVCPGEKSHSAVVRASVLLGKGPLGD-TFQPVFPERLWIEEEVFCNAFPFHVVFDEALR 397

  Fly   773 LK------------------GEDPF----RPEVESIIEAESC----PDYVLACIRDCWAEDPEER 811
            :|                  |.|.:    .|:|...| :..|    ..::|...|:...|..:.:
Mouse   398 VKQAGVNIQKYVPGILTQKFGLDEYFSIVHPQVTFNI-SSICKFINSQFILKTRREMMPEAWKSQ 461

  Fly   812 PEFSVIRNRLKKMRGGKTKNIMD----QMMEMMEKYANNLEDIVTERT---------------RL 857
            |... :|.::..|...|....|.    :.::.:|:...:|.||....|               .|
Mouse   462 PTLK-LRGQMIWMESLKCMVFMCSPKLRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMEL 525

  Fly   858 LCE-----------------EKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGF 905
            .|:                 ||.|||.||:.|||:.||.:|..|:.|....::..||.|||:|.|
Mouse   526 SCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEGKKVAAGEFETCTILFSDVVTF 590

  Fly   906 TAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMAL 970
            |.:.|...|:|:||.||.:|:.|||:...:|||||||||||||||.|:|:. .:.||..:|:.||
Mouse   591 TNICAACEPIQIVNMLNSMYSKFDRLTNIHDVYKVETIGDAYMVVGGVPVP-VESHAQRVANFAL 654

  Fly   971 ELLHAVKQHRIAHRP--NETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALK 1033
            .:..:.|:   ...|  .|.:::|:|:|||||:|||||..|||||||||||||||||||:|...|
Mouse   655 GMRISAKE---VMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNK 716

  Fly  1034 IHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPL---- 1094
            :|:|.....||:..|...:|  ||.:.:||||.:.|::|. .|.||.:   |::|..|..|
Mouse   717 VHLSPTAHRALENKGFEIVT--RGEIEVKGKGKMTTYFLI-RNLNATE---VEIMGRPSALADGK 775

  Fly  1095 -FSRPR---KSPKL---NPDSRQPSI---QAMHFCGTGSRRQS 1127
             .|.||   |.|:.   |.|..|..:   ......||.||..|
Mouse   776 EASTPRNQVKKPRAVLSNMDHHQQQVYNSDPADVLGTASRTAS 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593
		PK_GC-A_B	543..827	CDD:270944	37/209 (18%)
		HNOBA	<833..881	CDD:462234	20/83 (24%)
		CYCc	860..1052	CDD:214485	97/210 (46%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:462233	2/5 (40%)
		HNOBA	380..566	CDD:462234	37/187 (20%)
		Guanylate_cyc	572..754	CDD:425528	91/187 (49%)