DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001028494.1	Gene:	Gucy1a2 / 234889	MGIID:	2660877	Length:	730	Species:	Mus musculus

Alignment Length:	430	Identity:	133/430 - (30%)
Similarity:	201/430 - (46%)	Gaps:	98/430 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   665 IHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHI 729
            |.|.:|.:.|: ..|||...:           ..:::|...:...::....:|:   |..||
Mouse   269 IENEKLCFDGS-NPSNCSCLT-----------FLIKECETTQITKDNPQGTSQV---PADLR--- 315

  Fly   730 HGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIV-----------DYVKKLPLKGEDPFR--- 780
                         |....|.|..|| .:.|:...:|           .|.....||.||.|.
Mouse   316 -------------ISINTFCRAFPF-HLMFDSNMVVLQLGEGLRKQLRYDTHRALKFEDCFEIVS 366

  Fly   781 PEV----ESIIEAESCPDYVLACIRDCWAEDPEER-----------PEFSVIR-------NRLKK 823
            |.:    :.::...|.| :|:....:....:.|::           ||.|.|.       ::|.:
Mouse   367 PMINATFDRVLLRLSTP-FVIRTKPEASGTENEDKVMEIKGQMIHVPESSAILFLGSPCVDKLDE 430

  Fly   824 MRG--------------------GKTKNIMDQMMEMMEKYANNLEDIVTERT-RLLCEEKMKTED 867
            :.|                    |:.....|.:.:.|:|....|     ||| :.|.|||.||.|
Mouse   431 LMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATL-----ERTHQALEEEKKKTVD 490

  Fly   868 LLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRII 932
            ||:.:.|..||::|..||.|:...:|.||:.|||||||||:.|:.||:||::.||:|||.||...
Mouse   491 LLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQC 555

  Fly   933 RGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHT 997
            ...|:||||||||||.|.|||..|: ..||..||.|||:::...::  :.....:.:::|||:|:
Mouse   556 GLLDIYKVETIGDAYCVASGLHRKS-LCHAKPIALMALKMMELSEE--VLTPDGKAIQMRIGIHS 617

  Fly   998 GPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS 1037
            |.|:|||||:.||||||||:.|..||:.||.....:|::|
Mouse   618 GSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVS 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	36/217 (17%)
		HNOBA	<835..881	CDD:285003	18/46 (39%)
		CYCc	860..1052	CDD:214485	88/178 (49%)
		Guanylate_cyc	887..1074	CDD:278633	74/151 (49%)
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	44/209 (21%)
		CYCc	483..672	CDD:214485	88/178 (49%)
		Guanylate_cyc	512..696	CDD:278633	73/149 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810