DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and Adcy2

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	464	Identity:	120/464 - (25%)
Similarity:	190/464 - (40%)	Gaps:	120/464 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   676 LKSSNCVVTSRW------------MLQVTDFGLHELRQCAE-----------NESIGEHQ----H 713
            ||||..:....|            :|.:..|.:..|....|           |.|:.::|    |
Mouse   670 LKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANASNANVSVPDNQTAILH 734

  Fly   714 YRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDP 778
            .|| |:..|..:.:.|.|          :|...:|.|      :|:|.|.::..|
Mouse   735 ARN-LFFLPYFIYSCILG----------LISCSVFLR------VNYELKMLIMMV---------- 772

  Fly   779 FRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMM--- 840
                  :::.......:..|.:.|.:::...:||.   |...||.| |..:.:|....:.::
Mouse   773 ------ALVGYNIILLHTHAHVLDAYSQVLFQRPG---IWKDLKTM-GSVSLSIFFITLLVLGRQ 827

  Fly   841 -EKYANNLEDIVTERTRLLCEEKMKTED------------LLHRMLPQSVAE----KLTMGQGVE 888
             |.|.         |...|.:.|.|.|.            ||..:||..|||    :....:.:.
Mouse   828 SEYYC---------RLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELY 883

  Fly   889 PVSYDLVTIYFSDIVGFTAMSAES----TPLQVVNFLNDLYTVFDRII---RGYDVYKVETIGDA 946
            ..|||.|.:.|:.|..|.....||    ..|:.:..||::...||.::   :...|.|::|||..
Mouse   884 HQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGST 948

  Fly   947 YMVVSGLPIKNGDRHA----------GEIASMALEL---LHAVKQHRIAHRPNETLKLRIGMHTG 998
            ||..:||.......||          |.:...|..|   |.|:.:|..     ...|||:|::.|
Mouse   949 YMAATGLSAVPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINKHSF-----NDFKLRVGINHG 1008

  Fly   999 PVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKG 1063
            ||:|||:|...|:|.::|:|||.||||:|.|...||.::.:..|.|..|  ||....||::|:||
Mouse  1009 PVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTL--GYTCTCRGIINVKG 1071

  Fly  1064 KGDVVTWWL 1072
            |||:.|:::
Mouse  1072 KGDLKTYFV 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	34/177 (19%)
		HNOBA	<835..881	CDD:285003	14/65 (22%)
		CYCc	860..1052	CDD:214485	70/227 (31%)
		Guanylate_cyc	887..1074	CDD:278633	70/206 (34%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831
		CYCc	240..443	CDD:214485
		Guanylate_cyc	285..469	CDD:278633
		DUF1053	499..603	CDD:283888
		CYCc	852..1060	CDD:214485	67/214 (31%)
		Guanylate_cyc	882..1081	CDD:278633	70/206 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810