Protein Alignment CG42637 and gcy-21

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001364740.1
• Gene: gcy-21 / 191651
• WormBaseID: WBGene00001546
• Length: 1163
• Species: Caenorhabditis elegans
• Alignment Length: 1190
• Identity: 379/1190 - (31%)
• Similarity: 592/1190 - (49%)
• Gaps: 166/1190 - (13%)

  Fly     9 LLLLSVAVRDCSNHRTV----------LTVGYLT---ALTGDLKTRQGLA-ISGALTMALDEVNK 59
            :|||...:::..|...:          |.|.||.   ..||.....:|.| |..|:.:|::.:|.
 Worm     5 VLLLLFFIQNVQNFDKIELEDITVYFPLKVDYLAPFGCATGTKCDDEGAAYIPSAMEIAINRLNA 69

  Fly    60 DPNLLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAIVSQSRNIPMISYKC 124
            |.:|.....||:.:.|| ..|.....|.|..:.:|.....|....||:::.:....:...:|..|
 Worm    70 DKDLEVFHDLDVNYVDT-SKTAGPRAARTAALNNGTIAALGLMRDCYIQSTILNINSKIAVSDVC 133

  Fly   125 AEYRASAIPTFART----EPPDTQVVKSLLALLRYYAWNKFSILYEDVWSPVADLLKDQATKRN- 184
             |...|::..|.:|    ......:.||::..|..|.|.|.:::     || :.:|...||:..
 Worm   134 -EMDLSSVKGFDQTSVLMNSQTNSLAKSVMYFLDKYQWKKVALV-----SP-STVLTAFATRVRS 191

  Fly   185 -----MTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYV---FLGAANSLVDFMS 241
                 :|.|.....:|:|:.....:.|         .|:....:.||::   :...||.|.:::.
 Worm   192 DLLDALTANKIDILVDSRLDPMSDITD---------KVKEDAEKARIFIICDWSSNANLLRNYLF 247

  Fly   242 SMETAGLFARGEYMVI-FVDMMV-YSEREAEKYLRRVDQI--TFMSNCHSTEN-FNQMARSLLVV 301
            .:........|||.|: ::.... |...||....:|:..:  :.:::.:.||| .:::.::::::
 Worm   248 KLGEMNKMQSGEYFVLGYISYDTNYQWLEASSGDQRLVHLGASDINDYNLTENDLHEVYKNVVIL 312

  Fly   302 ASTPPTKD----YIQFTKQV-QKYSSK--PPF-NLEIPRLFVESNFSKFISIYAAYLYDSVKLYA 358
            :..||..:    :.....|| .|..:|  ||: |..:.    |....::..|  ..|:||::..|
 Worm   313 SDGPPPAEPNSTWEDIKSQVLMKKPAKMCPPYCNTTVS----EKITPRWDRI--KLLFDSIQYLA 371

  Fly   359 WAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYK 423
            .|.:..|.....:...|:.:|...  :|.||         |:||....||.||...|:..:..
 Worm   372 DATNDALNIGANIYQSDIFYEYLI--SRKID---------SVTGVTEFIDGYGAIVGSIQIYY-- 423

  Fly   424 PHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLING-----------SIDWPSGGEKPADEPMCG 477
             |..::|:|   :|.:.|.|...|.      .|:|.           |||:.: ...|.|.|:||
 Worm   424 -HFSSSSHN---SYSLFPCARLAQS------SLLNTVWSLTDYSEGLSIDFVN-KSAPKDTPVCG 477

  Fly   478 FANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEI------- 535
            |..|.|.....:....|.:|.:.||:..: :....:|::::.|..:..|.:.||.|:|
 Worm   478 FYGENCGPPANNTFIIVISVGVAVLIGLA-IAAAFLYKRYRYERRLHSLFFMIDRNQIILKKHTN 541

  Fly   536 ----------KGYSGNEIVSS---------------PSKVSLMSAQSYGS--------------- 560
                      ....|:.:.:|               .|.::..|..:.||
 Worm   542 LMSQQSLRSMASIHGSVVAASQTLRDSHFFIEDYNNASSINASSIFNTGSTARAGPFGPIPGFGG 606

  Fly   561 --------RWTNQFVTSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGAS 617
                    :|........|...|..|.:|.: :....:.:|.|..|:..|:|..:.|:..|:|..
 Worm   607 VTGASEDEKWHQIPDFGVGLYEGRTVALKRI-YRSDVEFTRSIRLEIAKLQESVNSNVIEFVGMV 670

  Fly   618 VEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCV 682
            |:...:.:|.:...:|||.||::|:|:.|||:|.:.:..|:|.|:.|:|:|.:..||.|||:||:
 Worm   671 VQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHSSPIGCHGRLKSTNCL 735

  Fly   683 VTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGS-------QKGDVYAF 740
            :.:|||::::.|||.|||.....:...:.|..::|||.:|||||.....|       ||.|||:.
 Worm   736 IDARWMVRLSSFGLRELRGEETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLLVQKSDVYSL 800

  Fly   741 AIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWA 805
            ||::||:|.|.||:|....||:|||..||:..|.|:.||||::..:.|:   |..|...:...|.
 Worm   801 AIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKES---PRIVQETVVAAWT 862

  Fly   806 EDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLH 870
            |||..||....|:.:||.:..|..:.|||.|:.|:|||.:.||..:.||...|..||.|:|.||.
 Worm   863 EDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEGEKAKSEALLK 927

  Fly   871 RMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGY 935
            .|||:.||:.|.:|..|...|::..|::|||..||..|||.|.|:.:|.|||||||||||||..:
 Worm   928 MMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFLNDLYTVFDRIIDQF 992

  Fly   936 DVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPV 1000
            ||||||||.|||||.||||:.||:.|||||||:.|.||.||:..:|.|.|||.::|||||::||.
 Worm   993 DVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFKIRHLPNEKVRLRIGMNSGPC 1057

  Fly  1001 VAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKG 1065
            |||||||.|||||||||||||||||||||..|:|:.|...|..||:| |||..|:||:|.|||||
 Worm  1058 VAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQL-GGYEIEERGIVEMKGKG 1121

  Fly  1066 DVVTWWLTGANENAIQKKLV 1085
            ..:|:::.|.|.:..:::::
 Worm  1122 KQMTYFVRGENSDMRRERII 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	100/448 (22%)
		PK_GC-A_B	543..827	CDD:270944	102/328 (31%)
		HNOBA	<833..881	CDD:462234	23/47 (49%)
		CYCc	860..1052	CDD:214485	120/191 (63%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:471960	85/397 (21%)
		PK_GC	612..881	CDD:270894	97/272 (36%)
		HNOBA	<890..938	CDD:462234	23/47 (49%)
		Guanylate_cyc	944..1130	CDD:425528	118/186 (63%)