Protein Alignment CG42637 and gcy-19

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001348702.1
• Gene: gcy-19 / 191650
• WormBaseID: WBGene00001544
• Length: 1187
• Species: Caenorhabditis elegans
• Alignment Length: 1223
• Identity: 368/1223 - (30%)
• Similarity: 570/1223 - (46%)
• Gaps: 190/1223 - (15%)

  Fly    20 SNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVL-A 83
            :|.||: .||.....|.:|.:.......||:.||:.::..|..:.|..: ::..|.|:.|..| |
 Worm    39 ANRRTI-RVGVAAVQTTELDSIGWPMSGGAINMAIQKLRDDGFIAPFDF-EVTVNYTECDRSLGA 101

  Fly    84 TKAITEMICDGIATIFGP--EGPCYVEAIVSQSRNIPMISYKCAEYRASAIPT---FARTE--PP 141
            ...:..|....:..:.||  ..|..:.|.::...:.||:.:        .:.|   |..||  |.
 Worm   102 AVGMEFMRTKRLDVVIGPPCRDPMEIMATMATYYSTPMLGW--------GLVTDSKFTDTERYPY 158

  Fly   142 DTQVVK-------SLLALLRYYAWNKFSILYEDVWS--PVADLLKDQATKRNMTINHKQSFIDNR 197
            .|.::.       ||:.||....|::.:::||:...  |:: ::.|..|    .||...:|..|.
 Worm   159 LTNIMANSLSLGFSLVKLLEMMEWDRVALVYEESAQDYPLS-VINDVET----AINEYDTFAVNV 218

  Fly   198 VKCCEQML--DCCRSGYWYQLVQNTMNRTRIYV-FLGAANSLVDFMSSMETAGLFARGEYMVIFV 259
            |  .:|.|  .......:..::.....|.||.| ....|.:...::..::..|: |..||:.|.:
 Worm   219 V--VKQALPGGDLNDAQYISVLNRIKLRCRIIVSVFQTAPTRRRYLKMIDQQGM-ANEEYVHILL 280

  Fly   260 DMMVYSEREAEKYLRRVDQITFMSNCHST---------------ENFNQMARSLLVVASTPPTKD 309
            .:......:....|.:.:     .||.|:               :...|.|..:||: ..|.|.|
 Worm   281 GLRSIGFGKQSAGLTKCE-----LNCLSSGLAPFWDIAPDDGLNDRLKQAATRMLVM-DLPDTMD 339

  Fly   310 ---------YIQ-FTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKM 364
                     |:. ||.........||.:...|.....|....  |.:|..|:|...||..|:..:
 Worm   340 LSTDVPDINYLNTFTMNCGAVVVNPPVSCATPACINASTSPP--SAFARSLHDVFYLYGLAITNL 402

  Fly   365 LREETRVLTD-DVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWN 428
            ..::...|.| |.|     ||...::       :..:|| ::.|:..........:.|.. .|::
 Worm   403 YNQDPAYLNDIDKI-----NGALQLN-------FAGLTG-EVSINANNSRVPKLMLYALN-DKYD 453

  Fly   429 NSNNMPCNYHM-----VPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDT 488
            .::.|...|.:     |.:||.::           .|:.:..||::|...|:||||...|.:...
 Worm   454 QASFMNLTYSLNGGASVSLAYTNE-----------ASLWYWYGGKRPLSVPVCGFAGTDCPQSFV 507

  Fly   489 HYTSTVAAVVLGVLLFCS-GVITMSIY--RKWKIELEIEGLLWKIDPNEIKG--------YSGNE 542
            .....:...:.|||:|.. .|||...|  |:.::|.:.....|:|...:::.        .|...
 Worm   508 DQYGALVFAIGGVLIFAMLFVITCFFYVMRQKRLERDRIDAEWQIPLVKLQAPPKRDKERMSKRS 572

  Fly   543 IVSSPSKVSLMSAQSYGSRWTN--------QFVTSTGRLRGAVVRIKELKFPRKRDISREIMKEM 599
            :.|.||.::..|..::.:.::|        :.|.||......::|.....|.|
 Worm   573 LQSGPSNITDTSKMTFDNTFSNYSIFYLDKEPVLSTAHPASNLIRTDYDTFVR------------ 625

  Fly   600 RLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIY 664
              ||:|.|:|:|.|:|.|::....|.|...|.:|||.|||...:..:|..|:..:|.|:.:|:.|
 Worm   626 --LRKLDHENVNKFVGMSIDGPEYLAVWKLCMRGSLQDIIGQGNFSIDPFFMFCVIRDMAEGLKY 688

  Fly   665 IHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHI 729
            :|||.|..|.||:|...:|...|..::|||||..|   ||.:.    ...|.|||.|||::|..:
 Worm   689 LHNSFLHVHANLRSGTVLVNESWQAKLTDFGLGTL---AEEKK----PMKRRQLWMAPEVIRGTL 746

  Fly   730 --HGSQK-GDVYAFAIIMYEIFSRKGPFGQINFEPKEIVD-YVKKLPLKGEDPFRPEVESIIEAE 790
              |..:| .|:|:.|:|..|:.:||..:...  |.|:.|| .|.::...|.:..|||::  ::..
 Worm   747 LPHQIEKSADIYSLAVIASEVLTRKEAWNMA--ERKDTVDEIVYRIKKGGPNAPRPELD--MDGV 807

  Fly   791 SCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERT 855
            .....:|..|||||:|:|.:||...||.|.||.|. .|..|:||.:..::|.|..|||..|.:||
 Worm   808 EINHNLLILIRDCWSEEPADRPSADVICNLLKNMM-PKKGNLMDHVFNILEDYTTNLEVEVEDRT 871

  Fly   856 RLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNF 920
            :.|..||.|.:.||.||||:.|||:|..||.|||..:|.||::|||:|.||.::|:.:|.||||.
 Worm   872 KELTAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQVVNL 936

  Fly   921 LNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRP 985
            |||||:.||.||..:..||||:|||.|:.|||||.|||:.|..:|..::|:.:...|..:|.|.|
 Worm   937 LNDLYSNFDAIIEEHGCYKVESIGDGYLCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPHLP 1001

  Fly   986 NETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS-NKCKLALDKLGG 1049
            .|.::||||:::||.|||||||:|||||||||||||||||||||:|..||:| ....|.:.....
 Worm  1002 REKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKASHIHLSAASYTLLMKHYPN 1066

  Fly  1050 GYITEKRGLVNMKGKGDVVTWWL-------TGANENA---IQKKLVDMMDMP-------PPLFS- 1096
            .|.|..||.|.:||||.:.|:|:       .|.:.|:   ..||..:....|       ||:..
 Worm  1067 QYNTASRGDVIIKGKGVMETFWVFERNNQFMGVSSNSGYQSDKKATNNGSSPESTPPSTPPMHEV 1131

  Fly  1097 ------RPRK-----SPKLNPDSRQPSIQA----MHFCGTGS-----RRQSTV 1129
                  |.||     ||.|:..|..|.::|    :|...|.:     |||.|:
 Worm  1132 KANSPVRHRKPPSPSSPTLSKRSVSPIMEAKARDIHNEETEALYRQFRRQETL 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	95/469 (20%)
		PK_GC-A_B	543..827	CDD:270944	95/295 (32%)
		HNOBA	<833..881	CDD:462234	23/47 (49%)
		CYCc	860..1052	CDD:214485	105/192 (55%)
gcy-19	NP_001348702.1	PBP1_NPR_GC-like	45..466	CDD:380575	93/459 (20%)
		Protein Kinases, catalytic domain	571..841	CDD:473864	94/294 (32%)
		CYCc	876..1065	CDD:214485	105/188 (56%)