DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and gcy-17

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	1154	Identity:	377/1154 - (32%)
Similarity:	580/1154 - (50%)	Gaps:	124/1154 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FNLLLLLSVAVRDCSNHRTVLTVGYL-TALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYL 69
            |...|:|:    :|...||: .||.| ......|:...|...|.|..:......::.::|.....
Worm     9 FTPFLILA----NCQARRTI-KVGLLFVQNVSSLQVGIGYRTSAAAVLVTKNKIREDHVLDGFDF 68

  Fly    70 DLRWNDTKGDTVL-ATKAITEMICDGIATIFGP--EGPCYVEAIVSQSRNIPMISYKCAEYR-AS 130
            :..|:..:.:.:| |.|.:..:....:..||||  ..|..:.:.::...|||:..:.....| .:
Worm    69 EFLWDFDECNEILGAGKTVDLLEVKKVDVIFGPTCSRPALISSALATYYNIPIFEWGLTSTRQLT 133

  Fly   131 AIPTFARTEP---PDTQVVKSLLALLRYYAWNKFSILY-EDVWSPVADLLKDQATKRNMTINHKQ 191
            .:..|..|.|   ....:..::|..|:.:.|.:|..|| .|......:.|||..  :.:...|::
Worm   134 DVKRFPTTLPFSVNSYSLAMAILGTLKQFQWTEFVFLYCNDGDDEKCESLKDDV--QTVASAHEE 196

  Fly   192 SFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFL-----GAANSLVDFMSSMETAGLFAR 251
            ..:....:...:.|:..|:.     :.....|.||.|..     |:..:|:..: ::|.|.   .
Worm   197 LSLAYTFRIQSKKLEDMRAA-----IVEIKKRGRIIVACVASGNGSKRTLMQAV-ALENAN---N 252

  Fly   252 GEYMVIFVDM----MVYSEREAE-KYL---RRVDQITFMSNCHSTENF-NQMARSLLVV----AS 303
            .||:.|..:.    .|..|...: .||   :..|..||     |||:. ..||..|.:|    .:
Worm   253 SEYVYIMAETNSRGFVVEEVGGKWHYLWEGKFDDSDTF-----STEDSRTSMANLLFLVDNMGMN 312

  Fly   304 TPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVE----SNFSKFISIYAAYLYDSVKLYAWAVDKM 364
            ...|..|:.|:|.|.:.....|||.      ||    ..:|. ::.||..|.|:...||.||:
Worm   313 NVVTPQYLNFSKNVIEMMKDEPFNC------VEDCVGEEYSS-VAKYAGQLADAFYAYAVAVN-- 368

  Fly   365 LREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNN 429
                 |:||.:...|: .|||.::..|  ..|:..:.|..:.:|.  ||.....::..    ..|
Worm   369 -----RLLTANPQAEI-RNGTMILRNI--GMTFEGVGGGDLTVDP--DSARTSEIIMI----GLN 419

  Fly   430 SNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTV 494
            |:.:|..|..:.:   :....|.|....:..:|..:|.::|..:|.|||....|..|.......:
Worm   420 SSRLPETYGKLII---NNQSVHFEQLYSDEVMDVWNGRQRPKAKPTCGFTGTQCPPDFVRDYLVI 481

  Fly   495 AAVVLGVLLF----CSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSA 555
            ..:::..|:|    ..|.:..:|.:|.| |:|.:..||.::.:.:|..| .:..|..|:.|..|.
Worm   482 VIIIVMFLIFAVSAAVGAVFYAIRQKRK-EIERQDELWHVEASHLKPIS-KKSKSEASQRSFASG 544

  Fly   556 QSYGSRWTNQFVTSTGRL--------RGAVVRIKELKF-PRKRDISREIMKEMRLLRELRHDNIN 611
            .|..::.|.:..|.|.|.        ...||...:..| |:..|:.|   .|:|.:|.|.|||:|
Worm   545 PSTSTKLTVESRTETTRFIFYIYQVRNNEVVAANKHDFRPQLTDVER---SELRQMRSLDHDNLN 606

  Fly   612 SFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNL 676
            .|||..:...::|.:..||::|||.|:|....:::|..|:.|||.|:..|:.:||.|.|.:||.|
Worm   607 KFIGLCLNSQQLLSIWRYCSRGSLADVISRSSMQMDSFFMLSLIRDIANGLGFIHTSMLHFHGYL 671

  Fly   677 KSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFA 741
            .|.:|::..||.::::||||:|:|...:..:       .|.||.|||:||.....|::.|:|:|.
Worm   672 SSRSCLIDDRWQVKISDFGLNEVRGMDKLST-------ENMLWWAPEVLRGLEQRSKEADIYSFG 729

  Fly   742 IIMYEIFSRKGPFGQIN--FEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCW 804
            ||..|:.:|...|...|  .:|:||:..:||   .|.:..||.:.:....|..|..| ..|||||
Worm   730 IICSEVITRSSAFDLENRKEKPEEIIYQLKK---GGFNAIRPSLLTDEALEINPALV-HLIRDCW 790

  Fly   805 AEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLL 869
            .|.|.|||....:|:.|:.|..||..|:||.:..|:|.||:.||:.|.|||:.|.||:.|::.||
Worm   791 TEKPSERPPIDQVRSLLRGMNDGKKGNLMDHVFNMLETYASTLEEEVNERTKELVEEQKKSDVLL 855

  Fly   870 HRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRG 934
            :||||::|||||..|..:||.:::||||:|||:|.||.::::.||||||..||||||:||.||..
Worm   856 YRMLPKTVAEKLKAGISIEPETFELVTIFFSDVVQFTTLASKCTPLQVVQLLNDLYTIFDSIIEQ 920

  Fly   935 YDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGP 999
            .||||||||||.|:.|||||.:||..|...||.|:|..|.::.:.|:||.|:|.:.||||::.|.
Worm   921 NDVYKVETIGDGYLCVSGLPHRNGHDHIKHIARMSLAFLSSLAEFRVAHMPSERINLRIGINCGS 985

  Fly  1000 VVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGK 1064
            ||||||||||||||||||.|||||||||||:..:||:|::....|..:.||:.||:||.|.:|||
Worm   986 VVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGRIHVSSEANHLLTHVVGGFRTEERGEVIIKGK 1050

  Fly  1065 GDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSI 1113
            |.:.|:||.|.|::.             |:.|..||  :.|..|...||
Worm  1051 GVMNTYWLLGENDSV-------------PVKSNMRK--RENTPSMARSI 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	98/449 (22%)
		ANF_receptor	48..412	CDD:279440	86/393 (22%)
		PK_GC-A_B	543..827	CDD:270944	100/294 (34%)
		HNOBA	<835..881	CDD:285003	23/45 (51%)
		CYCc	860..1052	CDD:214485	112/191 (59%)
		Guanylate_cyc	887..1074	CDD:278633	109/186 (59%)
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141	91/411 (22%)
		ANF_receptor	47..398	CDD:279440	84/383 (22%)
		PKc_like	539..808	CDD:304357	96/282 (34%)
		Pkinase	567..803	CDD:278497	88/249 (35%)
		HNOBA	<824..867	CDD:285003	23/42 (55%)
		CYCc	846..1038	CDD:214485	112/191 (59%)
		Guanylate_cyc	873..1060	CDD:278633	109/186 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D229634at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820