Protein Alignment CG42637 and gcy-15

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001364713.1
• Gene: gcy-15 / 191648
• WormBaseID: WBGene00001541
• Length: 1104
• Species: Caenorhabditis elegans
• Alignment Length: 1140
• Identity: 367/1140 - (32%)
• Similarity: 577/1140 - (50%)
• Gaps: 162/1140 - (14%)

  Fly    50 LTMALDEVNKDPNLLPNVYLDLRWNDTK---GDTVLATKAITEMICDGIATI--FGPEGPCYVEA 109
            :.:|::.:|.|.:|.....||:.:.||.   |.....|.|:..      ||:  .|....||:::
 Worm     1 MEIAINRLNADKDLEVFHDLDVNYVDTSKTAGPRAARTAALNN------ATVAAMGLMRDCYIQS 59

  Fly   110 IVSQSRNIPMISYKCAEYRASAIPTFART----EPPDTQVVKSLLALLRYYAWNKFSILYEDVWS 170
            .: .:.|:.:......|...|::..|.:|    ......:.||::..|..|.|.|.:::     |
 Worm    60 TI-LNINLKIAVSDVCEMDLSSVKGFDQTSVLMNSQTNSLAKSVMYFLDKYQWKKVALV-----S 118

  Fly   171 PVADLLKDQATKRN-----MTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYV-- 228
            |.|.|....|..|:     :|.|.....:|:|:   :.|.|..      :.|:....:.||::
 Worm   119 PSAVLTAFAARVRSDLLDALTANKIDILVDSRL---DPMSDIT------EKVKEDAEKARIFIIC 174

  Fly   229 -FLGAANSLVDFMSSMETAGLFARGEYMVI-FVDMMV-YSEREAEKYLRRVDQI--TFMSNCHST 288
             :...||.|.:::..:........|||.|: ::.... |...||....:|:..:  :.:::.:.|
 Worm   175 DWSSNANLLRNYIFKLGEMNKMQSGEYFVLGYISYDTNYQWLEASSGDQRLVHLGASDINDYNLT 239

  Fly   289 EN-FNQMARSLLVVASTPP------TKDYIQFTKQVQKYSSK--PPF-NLEIPRLFVESNFSKFI 343
            || .:::.:::::::..||      |.:.|: |:.::|..:|  ||: |..|.    |....::.
 Worm   240 ENDLHEVYKNVVILSDGPPPAEPNSTWEDIK-TQVLKKKPAKMCPPYCNTTIS----EKITPRWD 299

  Fly   344 SIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKID 408
            .|  ..|:||::..|.|.:..|.....:...|:.:|...  :|.:|         |:||....||
 Worm   300 RI--KLLFDSIQYLADATNDALNIGANIYQSDIFYEHLI--SRKVD---------SVTGVTEYID 351

  Fly   409 QYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLING-----------SID 462
            .||...|:..:..   |..::|:|   :|.:.|.|...|.      .|:|.           |||
 Worm   352 GYGAIVGSMQIYY---HFSSSSHN---SYSLFPCARLAQS------SLLNTVWSLTDYSEGLSID 404

  Fly   463 WPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLL 527
            :.: ...|.|.|:|||..|.|.....:....|.:|.:.||:..: :....:|::::.|..:..|.
 Worm   405 FVN-KSAPKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLA-IAAAFLYKRYRYERRLHSLF 467

  Fly   528 WKIDPNEI-----------------KGYSGNEIVSS---------------PSKVSLMSAQSYGS 560
            :.||.|:|                 ....|:.:.:|               .|.::..|..:.||
 Worm   468 FMIDRNQIILKKHTNLMSQQSLRSMASIHGSVVAASQTLRDSHFFIEDYNNASSINASSIFNTGS 532

  Fly   561 -----------------------RWTNQFVTSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLL 602
                                   :|........|...|..|.:|.: :....:.:|....|:..|
 Worm   533 TARAGPFGPIPGFGGVTGASEDEKWHQIPDFGVGLYEGRTVALKRI-YRSDVEFTRSNRLEIAKL 596

  Fly   603 RELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHN 667
            :|..:.|:..|:|..|:...:.:|.:...:|||.||::|:|:.|||:|.:.:..|:|.|:.|:|:
 Worm   597 QESVNSNVIEFVGMVVQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHS 661

  Fly   668 SQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGS 732
            |.:..||.|||:||::.:|||::::.|||.|||.....:...:.|..::|||.:|||||.....|
 Worm   662 SPVGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQEDDVQEGKDQLWTSPELLRWSTGLS 726

  Fly   733 -------QKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAE 790
                   ||.|||:.||::||:|.|.||:|....||:|||..||:..|.|:.||||::..:.|:
 Worm   727 QCGVLLVQKSDVYSLAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKES- 790

  Fly   791 SCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERT 855
              |..|...:...|.|||..||....|:.:||.:..|..:.|||.|:.|:|||.:.||..:.||.
 Worm   791 --PRIVQETVVAAWTEDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERN 853

  Fly   856 RLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNF 920
            ..|..||.|:|.||..|||:.||:.|.:|..|...|::..|::|||..||..|||.|.|:.:|.|
 Worm   854 EELEAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQF 918

  Fly   921 LNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRP 985
            ||||||||||||..:||||||||.|||||.||||:.||:.|||||||:.|.||.||:..:|.|.|
 Worm   919 LNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFKIRHLP 983

  Fly   986 NETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGG 1050
            ||.::|||||::||.|||||||.|||||||||||||||||||||..|:|:.|...|..||:| ||
 Worm   984 NEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQL-GG 1047

  Fly  1051 YITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLV 1085
            |..|:||:|.|||||..:|:::.|.|.:..:::::
 Worm  1048 YEIEERGIVEMKGKGKQMTYFVRGENSDMRRERII 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	93/425 (22%)
		PK_GC-A_B	543..827	CDD:270944	101/328 (31%)
		HNOBA	<833..881	CDD:462234	23/47 (49%)
		CYCc	860..1052	CDD:214485	120/191 (63%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:471960	87/399 (22%)
		PK_GC	553..822	CDD:270894	96/272 (35%)
		HNOBA	<831..879	CDD:462234	23/47 (49%)
		Guanylate_cyc	885..1071	CDD:425528	118/186 (63%)