Protein Alignment CG42637 and gcy-14

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_506660.2
• Gene: gcy-14 / 191647
• WormBaseID: WBGene00001540
• Length: 1111
• Species: Caenorhabditis elegans
• Alignment Length: 1157
• Identity: 369/1157 - (31%)
• Similarity: 548/1157 - (47%)
• Gaps: 173/1157 - (14%)

  Fly    28 VGYLTALTGDLKTRQGLAISGAL-------TMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATK 85
            |||.|:....|..|..:.....|       |:..||.                  |:|   ||..
 Worm    37 VGYRTSAAAVLVARDRIRAEHLLDQYDFNFTVKFDEC------------------TEG---LAGG 80

  Fly    86 AITEMI-CDGIATIFGPEGPCYVEAIVSQS----RNIPMISY---KCAEY-RASAIPTFARTEPP 141
            ...|:| .|.:..|.||  .|....|...|    .|:|:..:   ..|:. ..|..||.......
 Worm    81 KTVELINHDNVDVIIGP--TCNRAGIAVASLAAYYNVPVFQWGLTTAADIGNVSRYPTTVTLSLD 143

  Fly   142 DTQVVKSLLALLRYYAWNKFSILY-EDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQML 205
            ...:...:..:||.:.|::|..:| .|........:||...|  |.|.:....:...|:.....|
 Worm   144 THSMALGVREVLRRFEWDEFVFIYSNDGDEEKCASMKDDLEK--MGIENSDVTLAYMVQIQTVTL 206

  Fly   206 DCCRSGYWYQLVQNTMNRTRIYV--FLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSERE 268
            |..:     :.:.....|.||.:  |.........|::|...||: :..|||.:|      :|.:
 Worm   207 DALQ-----KALTEVSKRGRIIIACFANGRGFKKAFVASTVLAGM-STDEYMYMF------AEPQ 259

  Fly   269 AEKYLRRVDQI-------------TFMSNCHSTENFNQMARSLLVVAS-----TPPTKDYIQFTK 315
            :..:.  ||:|             .|::.. :.|........:|.:..     |..|.::..|:.
 Worm   260 SRGFY--VDEINGGEHYSWDDTDGNFVTGL-TPEQIRDAYGKVLYICDNMGLPTTITPEFANFSS 321

  Fly   316 QVQKYSSKPPFNLEIPRLFVE--SNFS-KFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVI 377
            |:....::.|||.      |:  ||.: |..:.||..|:|:...|..|::       |.||.|..
 Worm   322 QLISRMTEQPFNC------VQDCSNSTYKVPATYAGQLFDAFYAYGVALN-------RSLTQDPT 373

  Fly   378 FEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDS-------EGNFSVLAYKPHKWNNSNNMPC 435
            .....||:.|:..|  ..::..:.|..:.:|..|..       ..|.|:|.|.      :.::..
 Worm   374 RANLKNGSFVLSDI--GMSFQGVGGGTVTLDDTGTRIVQVYMFALNTSLLPYL------AASLVI 430

  Fly   436 NYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTH----YTSTVAA 496
            |...|....|::.|...          |   ..:|...|:|||:...|..|...    ||...|.
 Worm   431 NGSEVEYTPFYKSEADL----------W---SVRPLARPICGFSGLECPPDFVKEYLVYTIIAAV 482

  Fly   497 -VVLGVLLFCSGVI-TMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSK--VSLMSAQS 557
             |||.:|..|:|:: ||.:.||   |:|.:.|||::...|:      :.|.|.||  .|:.|..|
 Worm   483 IVVLALLAGCAGLLYTMQMKRK---EMERQDLLWQVPFIEL------QQVQSKSKAEASMHSFAS 538

  Fly   558 YGSRWTNQFVTSTGRLRGAVVRI------KELKFPRKRDI----SREIMKEMRLLRELRHDNINS 612
            ..|..|...|.|    |...:..      :::....|.|:    ..|...|.|.:|...:||:|.
 Worm   539 GPSTSTKITVES----RSETINFIFYYYQQDILAAMKHDLILQFDAEQKAEFRQMRNFDNDNLNK 599

  Fly   613 FIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLK 677
            |||..::..::..:..:|::|||.|:|....:::|..|:.|||.|:..|:::||||.|..||:|.
 Worm   600 FIGLCLDGPQLFSLWRFCSRGSLSDVISKSSMQMDSFFMFSLIRDISNGLLFIHNSFLKCHGHLT 664

  Fly   678 SSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRN-HIHGSQKGDVYAFA 741
            |..|::..||.::::.:||..:|..       |:....:.||..||.||| :.....:||:|:|.
 Worm   665 SRCCLIDDRWQIKISGYGLKSVRTF-------ENPKKEDLLWTPPENLRNENEERLPEGDIYSFG 722

  Fly   742 IIMYEIFSRKGPFGQIN--FEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCW 804
            ||..||.:|...|...|  .:|..|:..|||   .|.:|.||.:::....|..| .:|..|||||
 Worm   723 IICSEILTRSSAFDLENRKEKPDVIIYQVKK---GGHNPMRPSLDTGETVEINP-ALLHLIRDCW 783

  Fly   805 AEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLL 869
            .|.|.|||....:|..|..||.|:..|:||.:..|:|.||:.||:.|::||:.|.|||.|::.||
 Worm   784 TERPSERPSIEQVRGHLNGMRDGRKSNLMDHVFNMLETYASTLEEEVSDRTKELVEEKKKSDVLL 848

  Fly   870 HRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRG 934
            :||||:.||:||.:||.|||.:::.|||:|||:|.||.::.:.||||||..||||||:||.||..
 Worm   849 YRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQ 913

  Fly   935 YDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGP 999
            .||||||||||.|:.|||||.:||:.|...||.|:|..|.:::..|:.|.|:|.:.||||::.|.
 Worm   914 NDVYKVETIGDGYLCVSGLPHRNGNEHIRHIARMSLGFLSSLEFFRVQHLPSERINLRIGINCGS 978

  Fly  1000 VVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGK 1064
            ||||||||||||||||||.|||||||||||:..|||::.:....|.::.||:.||.||.|.:|||
 Worm   979 VVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVGGFRTESRGEVIIKGK 1043

  Fly  1065 GDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAM 1116
            |.:.|:||.|................|.|    ||:.   :..|..|.|:.|
 Worm  1044 GVMETYWLLGEQSRISVSAQAPREKTPEP----PRRQ---SVRSISPIIEKM 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	96/463 (21%)
		PK_GC-A_B	543..827	CDD:270944	97/298 (33%)
		HNOBA	<833..881	CDD:462234	24/47 (51%)
		CYCc	860..1052	CDD:214485	112/191 (59%)
gcy-14	NP_506660.2	PBP1_NPR_GC-like	21..419	CDD:380575	91/436 (21%)
		Protein Kinases, catalytic domain	535..800	CDD:473864	89/279 (32%)
		HNOBA	<816..860	CDD:462234	22/43 (51%)
		CYCc	839..1031	CDD:214485	112/191 (59%)